5-hydroxydecanoate has been researched along with Ventricular Fibrillation in 14 studies
5-hydroxydecanoic acid: Potassium Channel Blocker; RN refers to parent cpd
Ventricular Fibrillation: A potentially lethal cardiac arrhythmia that is characterized by uncoordinated extremely rapid firing of electrical impulses (400-600/min) in HEART VENTRICLES. Such asynchronous ventricular quivering or fibrillation prevents any effective cardiac output and results in unconsciousness (SYNCOPE). It is one of the major electrocardiographic patterns seen with CARDIAC ARREST.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We investigated the effects of sodium 5-hydroxydecanoate (5-HD) on experimentally induced ischemic arrhythmia and its mechanisms of action by biochemical and electrophysiological techniques." | 7.67 | [Study of mechanism and effect of sodium 5-hydroxydecanoate on experimental ischemic ventricular arrhythmia]. ( Dabasaki, T; Funato, H; Ishikawa, H; Kayamoto, M; Niho, T; Notsu, T; Takahashi, H; Tanaka, I; Yamasaki, F; Yamazaki, M, 1987) |
| " In this study, we investigated whether TZDs affect onset, spectral characteristics, and mortality of ischemic ventricular fibrillation (VF) and whether such effects are recapitulated by a non-selective K(ATP) blocker (glyburide) or a mitochondrial K(ATP) blocker (5-hydroxydecanoate)." | 3.78 | Thiazolidinedione drugs promote onset, alter characteristics, and increase mortality of ischemic ventricular fibrillation in pigs. ( Greyson, CR; Lu, L; Reiter, MJ; Sarraf, M; Schwartz, GG; Ye, S, 2012) |
| " The purpose of this study was to investigate the roles of loss of oxidative phosphorylation and activation of the mitochondrial ATP-sensitive K+ channel and permeability transition pore in VF development during myocardial ischemia by using mitochondrial uncoupling agents (carbonyl cyanide m-chlorophenylhydrazone and 2,4-dinitrophenol) and channel blockers (5-hydroxydecanoate and cyclosporine A) at concentrations that have been demonstrated to block the intended targets selectively." | 3.77 | Mitochondrial uncoupling agents trigger ventricular fibrillation in isolated rat hearts. ( Alderson, JM; Clements-Jewery, H; Hatcher, AS, 2011) |
| " Here, we have assessed its effects on ischaemia- and reperfusion-induced ventricular arrhythmias in vivo and a possible role for mitochondrial K(ATP) channels in these effects, using the channel inhibitor 5-hydroxydecanoate (5-HD)." | 3.74 | Peroxynitrite decreases arrhythmias induced by ischaemia reperfusion in anaesthetized dogs, without involving mitochondrial KATP channels. ( Huliák, I; Juhász, L; Kiss, A; Végh, A, 2008) |
| " This study was designed to determine whether clofilium exhibits antifibrillatory activity in a pinacidil + hypoxia-induced model of ventricular fibrillation (VF) in Langendorff-perfused hearts." | 3.69 | Antifibrillatory effects of clofilium in the rabbit isolated heart. ( Chi, L; Friedrichs, GS; Green, AL; Lucchesi, BR, 1994) |
| "We investigated the effects of sodium 5-hydroxydecanoate (5-HD) on experimentally induced ischemic arrhythmia and its mechanisms of action by biochemical and electrophysiological techniques." | 3.67 | [Study of mechanism and effect of sodium 5-hydroxydecanoate on experimental ischemic ventricular arrhythmia]. ( Dabasaki, T; Funato, H; Ishikawa, H; Kayamoto, M; Niho, T; Notsu, T; Takahashi, H; Tanaka, I; Yamasaki, F; Yamazaki, M, 1987) |
| "Arrhythmias were assessed based on the Lambeth convention and were categorized as number, duration and incidence of ventricular tachycardia (VT), ventricular fibrillation (VF), and premature ventricular complexes (PVC), and arrhythmic score." | 1.40 | Anti-arrhythmic effect of diosgenin in reperfusion-induced myocardial injury in a rat model: activation of nitric oxide system and mitochondrial KATP channel. ( Badalzadeh, R; Ebrahimi, H; Majidinia, M; Yousefi, B, 2014) |
| "The duration of ventricular tachycardia (VT) + VF, the number of VT + VF episodes and the severity of arrhythmias were all significantly reduced by Ex-4 compared to those in myocardial ischemia group (p < 0." | 1.39 | Exendin-4 attenuates ischemia-induced ventricular arrhythmias in rats. ( Daoqun, J; Jie, G; Kai, Z; Lin, Z; Yongbo, W; Zhiqiang, C, 2013) |
| "Control animals had an average arrhythmia score of 10." | 1.31 | Opioid-induced cardioprotection against myocardial infarction and arrhythmias: mitochondrial versus sarcolemmal ATP-sensitive potassium channels. ( Fryer, RM; Gross, GJ; Hsu, AK; Nagase, H, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (7.14) | 18.7374 |
| 1990's | 3 (21.43) | 18.2507 |
| 2000's | 6 (42.86) | 29.6817 |
| 2010's | 4 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kai, Z | 1 |
| Yongbo, W | 1 |
| Lin, Z | 1 |
| Jie, G | 1 |
| Daoqun, J | 1 |
| Zhiqiang, C | 1 |
| Badalzadeh, R | 1 |
| Yousefi, B | 1 |
| Majidinia, M | 1 |
| Ebrahimi, H | 1 |
| Kiss, A | 1 |
| Juhász, L | 1 |
| Huliák, I | 1 |
| Végh, A | 1 |
| Hatcher, AS | 1 |
| Alderson, JM | 1 |
| Clements-Jewery, H | 1 |
| Sarraf, M | 1 |
| Lu, L | 1 |
| Ye, S | 1 |
| Reiter, MJ | 1 |
| Greyson, CR | 1 |
| Schwartz, GG | 1 |
| Iliodromitis, EK | 1 |
| Cokkinos, P | 1 |
| Zoga, A | 1 |
| Steliou, I | 1 |
| Vrettou, AR | 1 |
| Kremastinos, DT | 1 |
| Maslov, LN | 1 |
| Lishmanov, YB | 1 |
| Solenkova, NV | 1 |
| Gross, GJ | 2 |
| Stefano, GB | 1 |
| Tam, SW | 1 |
| Xu, D | 1 |
| Li, Y | 1 |
| Wang, J | 1 |
| Davey, AK | 1 |
| Zhang, S | 1 |
| Evans, AM | 1 |
| Vajda, S | 1 |
| Baczkó, I | 1 |
| Leprán, I | 1 |
| Friedrichs, GS | 2 |
| Chi, L | 2 |
| Green, AL | 1 |
| Lucchesi, BR | 2 |
| Abreu, JN | 1 |
| Black, SC | 1 |
| Wolk, R | 1 |
| Cobbe, SM | 1 |
| Kane, KA | 1 |
| Hicks, MN | 1 |
| Fryer, RM | 1 |
| Hsu, AK | 1 |
| Nagase, H | 1 |
| Niho, T | 1 |
| Notsu, T | 1 |
| Ishikawa, H | 1 |
| Funato, H | 1 |
| Yamazaki, M | 1 |
| Takahashi, H | 1 |
| Tanaka, I | 1 |
| Kayamoto, M | 1 |
| Dabasaki, T | 1 |
| Yamasaki, F | 1 |
14 other studies available for 5-hydroxydecanoate and Ventricular Fibrillation
| Article | Year |
|---|---|
Exendin-4 attenuates ischemia-induced ventricular arrhythmias in rats.
Topics: Animals; Anti-Arrhythmia Agents; Blood Pressure; Decanoic Acids; Disease Models, Animal; Exenatide; | 2013 |
Anti-arrhythmic effect of diosgenin in reperfusion-induced myocardial injury in a rat model: activation of nitric oxide system and mitochondrial KATP channel.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cardiotonic Agents; Decanoic Acids; Diosgenin | 2014 |
Peroxynitrite decreases arrhythmias induced by ischaemia reperfusion in anaesthetized dogs, without involving mitochondrial KATP channels.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Coronary Vessels; Decanoic Acids; Dogs; Femal | 2008 |
Mitochondrial uncoupling agents trigger ventricular fibrillation in isolated rat hearts.
Topics: 2,4-Dinitrophenol; Adenosine Triphosphate; Animals; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cyclo | 2011 |
Thiazolidinedione drugs promote onset, alter characteristics, and increase mortality of ischemic ventricular fibrillation in pigs.
Topics: Animals; Anti-Arrhythmia Agents; Coronary Vessels; Death, Sudden, Cardiac; Decanoic Acids; Female; G | 2012 |
Oral nicorandil recaptures the waned protection from preconditioning in vivo.
Topics: Administration, Oral; Animals; Blood Pressure; Decanoic Acids; Disease Models, Animal; Drug Combinat | 2003 |
Activation of peripheral delta opioid receptors eliminates cardiac electrical instability in a rat model of post-infarction cardiosclerosis via mitochondrial ATP-dependent K+ channels.
Topics: Adenosine Triphosphate; Analgesics, Opioid; Animals; Decanoic Acids; Disease Models, Animal; Drug An | 2003 |
The cardioprotective effect of isosteviol on rats with heart ischemia-reperfusion injury.
Topics: Animals; Anti-Arrhythmia Agents; Cardiotonic Agents; Decanoic Acids; Disease Models, Animal; Diterpe | 2007 |
Selective cardiac plasma-membrane K(ATP) channel inhibition is defibrillatory and improves survival during acute myocardial ischemia and reperfusion.
Topics: Acute Disease; Anesthesia; Animals; Anti-Arrhythmia Agents; Autonomic Nervous System; Blood Pressure | 2007 |
Antifibrillatory effects of clofilium in the rabbit isolated heart.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Decanoic Acids; Disease Models, Animal; Glyburid | 1994 |
5-hydroxydecanoate fails to attenuate ventricular fibrillation in a conscious canine model of sudden cardiac death.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Blood Pressure; Death, Sudden, Cardiac; Decanoic | 1996 |
Relevance of inter- and intraventricular electrical dispersion to arrhythmogenesis in normal and ischaemic rabbit myocardium: a study with cromakalim, 5-hydroxydecanoate and glibenclamide.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Coronary Disease; Cromakal | 1999 |
Opioid-induced cardioprotection against myocardial infarction and arrhythmias: mitochondrial versus sarcolemmal ATP-sensitive potassium channels.
Topics: Adenosine Triphosphate; Analgesics, Opioid; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; B | 2000 |
[Study of mechanism and effect of sodium 5-hydroxydecanoate on experimental ischemic ventricular arrhythmia].
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Coronary Disease; Decanoic Acids; Dogs; Energ | 1987 |