5-hydroxydecanoate has been researched along with Myocardial Ischemia in 74 studies
5-hydroxydecanoic acid: Potassium Channel Blocker; RN refers to parent cpd
Myocardial Ischemia: A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).
| Excerpt | Relevance | Reference |
|---|---|---|
| "We investigated whether (endogenous) hydrogen sulfide (H2S) protects the heart against myocardial ischemia and reperfusion injury." | 7.73 | The production of hydrogen sulfide limits myocardial ischemia and reperfusion injury and contributes to the cardioprotective effects of preconditioning with endotoxin, but not ischemia in the rat. ( McDonald, MC; Sivarajah, A; Thiemermann, C, 2006) |
| " In the present study, we investigated the effects of the administration of non-hypotensive doses of ATP-sensitive K+ channel (KATP) openers (nicorandil and 3-pyridyl pinacidil), a specific mitochondrial KATP channel blocker (5-hydroxydecanoate) and a specific sarcolemmal KATP channel blocker (HMR 1883; 1-[5-[2-(5-chloro-o-anisamido)ethyl]-2-methoxyphenyl]sulfonyl-3- methylthiourea) prior to and during coronary occlusion, as well as prior to and during post-ischemic reperfusion, on survival rate, ischemia-induced and reperfusion-induced arrhythmias and myocardial infarct size in anesthetized albino rabbits." | 7.72 | Selective mitochondrial KATP channel activation by nicorandil and 3-pyridyl pinacidil results in antiarrhythmic effect in an anesthetized rabbit model of myocardial ischemia/reperfusion. ( Das, B; Sarkar, C, 2003) |
| "We investigated the effects of administration of non-hypotensive doses of ATP-sensitive K+ channel (KATP) openers (nicorandil and bimakalim), and a specific mitochondrial KATP channel blocker (5-hydroxydecanoate) prior to and during coronary occlusion as well as prior to and during post-ischemic reperfusion on survival rate, ischemia-induced and reperfusion-induced arrhythmias and myocardial infarct size in anesthetized albino rabbits." | 7.71 | Effects of administration of nicorandil or bimakalim prior to and during ischemia or reperfusion on survival rate, ischemia/reperfusion-induced arrhythmias and infarct size in anesthetized rabbits. ( Das, B; Karanth, KS; Sarkar, C, 2001) |
| "Hydrogen sulfide (H2S) is a gaseous mediator, produced by the metabolic pathways that regulate tissue concentrations of sulfur-containing amino acids." | 5.33 | Exogenous hydrogen sulfide (H2S) protects against regional myocardial ischemia-reperfusion injury--Evidence for a role of K ATP channels. ( Baxter, GF; Johansen, D; Ytrehus, K, 2006) |
| " The purpose of this study was to investigate the roles of loss of oxidative phosphorylation and activation of the mitochondrial ATP-sensitive K+ channel and permeability transition pore in VF development during myocardial ischemia by using mitochondrial uncoupling agents (carbonyl cyanide m-chlorophenylhydrazone and 2,4-dinitrophenol) and channel blockers (5-hydroxydecanoate and cyclosporine A) at concentrations that have been demonstrated to block the intended targets selectively." | 3.77 | Mitochondrial uncoupling agents trigger ventricular fibrillation in isolated rat hearts. ( Alderson, JM; Clements-Jewery, H; Hatcher, AS, 2011) |
| "Polyphenol (-)-epigallocatechin gallate (EGCG), the most abundant catechin of green tea, appears to attenuate myocardial ischemia/reperfusion injury." | 3.76 | Polyphenol (-)-epigallocatechin gallate during ischemia limits infarct size via mitochondrial K(ATP) channel activation in isolated rat hearts. ( Chun, KJ; Jang, Y; Kim, JH; Lee, D; Song, DK; Xu, Z, 2010) |
| "We investigated whether (endogenous) hydrogen sulfide (H2S) protects the heart against myocardial ischemia and reperfusion injury." | 3.73 | The production of hydrogen sulfide limits myocardial ischemia and reperfusion injury and contributes to the cardioprotective effects of preconditioning with endotoxin, but not ischemia in the rat. ( McDonald, MC; Sivarajah, A; Thiemermann, C, 2006) |
| " In the present study, we investigated the effects of the administration of non-hypotensive doses of ATP-sensitive K+ channel (KATP) openers (nicorandil and 3-pyridyl pinacidil), a specific mitochondrial KATP channel blocker (5-hydroxydecanoate) and a specific sarcolemmal KATP channel blocker (HMR 1883; 1-[5-[2-(5-chloro-o-anisamido)ethyl]-2-methoxyphenyl]sulfonyl-3- methylthiourea) prior to and during coronary occlusion, as well as prior to and during post-ischemic reperfusion, on survival rate, ischemia-induced and reperfusion-induced arrhythmias and myocardial infarct size in anesthetized albino rabbits." | 3.72 | Selective mitochondrial KATP channel activation by nicorandil and 3-pyridyl pinacidil results in antiarrhythmic effect in an anesthetized rabbit model of myocardial ischemia/reperfusion. ( Das, B; Sarkar, C, 2003) |
| " Intravenous injection of protein kinase C inhibitors chelerythrine (5 mg/kg) and staurosporine (50 microg/kg) or a specific mitochondrial K(ATP) channel inhibitor 5-hydroxydecanoate (5 mg/kg) 5 min before sustained myocardial ischemia abolished the preconditioning afforded by intestinal ischemia." | 3.71 | Intestinal ischemia preconditions myocardium: role of protein kinase C and mitochondrial K(ATP) channel. ( Maeta, H; Mizoguchi, K; Oe, M; Suzuki, T; Wang, YP; Yamashita, Y, 2002) |
| "We investigated the effects of administration of non-hypotensive doses of ATP-sensitive K+ channel (KATP) openers (nicorandil and bimakalim), and a specific mitochondrial KATP channel blocker (5-hydroxydecanoate) prior to and during coronary occlusion as well as prior to and during post-ischemic reperfusion on survival rate, ischemia-induced and reperfusion-induced arrhythmias and myocardial infarct size in anesthetized albino rabbits." | 3.71 | Effects of administration of nicorandil or bimakalim prior to and during ischemia or reperfusion on survival rate, ischemia/reperfusion-induced arrhythmias and infarct size in anesthetized rabbits. ( Das, B; Karanth, KS; Sarkar, C, 2001) |
| "We investigated the effects of administration of non-hypotensive doses of ATP-sensitive K+ channel (K(ATP)) openers (nicorandil and aprikalim), and a specific mitochondrial K(ATP) channel blocker (5-hydroxydecanoate) prior to and during coronary occlusion as well as prior to and during post-ischemic reperfusion on survival rate, ischemia/reperfusion-induced arrhythmias and myocardial infarct size in anesthetized albino rabbits." | 3.71 | Selective mitochondrial K(ATP) channel activation results in antiarrhythmic effect during experimental myocardial ischemia/reperfusion in anesthetized rabbits. ( Das, B; Karanth, KS; Sarkar, C, 2002) |
| ", cromakalim, pinacidil) are potent relaxants of smooth muscle, their utility for treating myocardial ischemia may be limited by hypotension." | 3.69 | Cardioprotective profile of the cardiac-selective ATP-sensitive potassium channel opener BMS-180448. ( Atwal, KS; D'Alonzo, AJ; Grover, GJ; McCullough, JR; Sargent, CA, 1995) |
| "The duration of ventricular tachycardia (VT) + VF, the number of VT + VF episodes and the severity of arrhythmias were all significantly reduced by Ex-4 compared to those in myocardial ischemia group (p < 0." | 1.39 | Exendin-4 attenuates ischemia-induced ventricular arrhythmias in rats. ( Daoqun, J; Jie, G; Kai, Z; Lin, Z; Yongbo, W; Zhiqiang, C, 2013) |
| "Treatment with sulforaphane inhibited an increase in the post-ischemic left ventricular end-diastolic pressure (LVEDP) and improved the post-ischemic left ventricular developed pressure (LVDP), +/-dP/dt, and coronary flow as compared with the untreated control hearts." | 1.36 | Sulforaphane protects ischemic injury of hearts through antioxidant pathway and mitochondrial K(ATP) channels. ( Chae, HJ; Chae, SW; Gao, S; Kim, DS; Kim, SH; Lee, GH; Park, BH; Piao, CS, 2010) |
| "Hydrogen sulfide (H2S) is a gaseous mediator, produced by the metabolic pathways that regulate tissue concentrations of sulfur-containing amino acids." | 1.33 | Exogenous hydrogen sulfide (H2S) protects against regional myocardial ischemia-reperfusion injury--Evidence for a role of K ATP channels. ( Baxter, GF; Johansen, D; Ytrehus, K, 2006) |
| "Sevoflurane was washed out for 30 min, and 5-HD for 15 min, before 30-min ischemia and 120-min reperfusion." | 1.32 | Preconditioning with sevoflurane reduces changes in nicotinamide adenine dinucleotide during ischemia-reperfusion in isolated hearts: reversal by 5-hydroxydecanoic acid. ( Camara, AK; Chen, Q; Eells, JT; Novalija, E; Riess, ML; Stowe, DF, 2003) |
| "Pinacidil solutions have been shown to have significant cardioprotective effects." | 1.32 | Donor heart preservation with pinacidil: the role of the mitochondrial K ATP channel. ( Damiano, RJ; Diodato, MD; Gaynor, SL; Lawton, JS; Prasad, SM; Shah, NR, 2004) |
| "Nicorandil is a hybrid of nitrate and a K(ATP) channel opener that activates the sarcK(ATP) and mitoK(ATP) channels." | 1.31 | Infarct size limitation by nicorandil: roles of mitochondrial K(ATP) channels, sarcolemmal K(ATP) channels, and protein kinase C. ( Ichikawa, Y; Kuno, A; Matsumoto, T; Miki, T; Miura, T; Ohnuma, Y; Sakamoto, J; Shimamoto, K; Tanno, M; Tsuchida, A, 2002) |
| "Sevoflurane was washed out for 30 min and 5-HD for 15 min before 30 min of global ischemia and 120 min of reperfusion." | 1.31 | Anesthetic preconditioning attenuates mitochondrial Ca2+ overload during ischemia in Guinea pig intact hearts: reversal by 5-hydroxydecanoic acid. ( Camara, AK; Chen, Q; Novalija, E; Rhodes, SS; Riess, ML; Stowe, DF, 2002) |
| "Control animals had an average arrhythmia score of 10." | 1.31 | Opioid-induced cardioprotection against myocardial infarction and arrhythmias: mitochondrial versus sarcolemmal ATP-sensitive potassium channels. ( Fryer, RM; Gross, GJ; Hsu, AK; Nagase, H, 2000) |
| "Diazoxide pretreatment significantly improved the recovery of LV function and coronary flow compared to control (LVDP: 49 +/- 5* vs." | 1.31 | Diazoxide protects the rabbit heart following cardioplegic ischemia. ( Feng, J; Li, H; Rosenkranz, ER, 2002) |
| "Pre-treatment with cromakalim delayed the time to ischemic contracture (19." | 1.30 | Effects of cromakalim and glibenclamide on myocardial high energy phosphates and intracellular pH during ischemia-reperfusion: 31P NMR studies. ( Deslauriers, R; Docherty, JC; Gunter, HE; Kuzio, B; Shoemaker, L; Yang, L, 1997) |
| "Diazoxide (1 mg/kg) was administered either 30 min (for EP) or 24 h (DP) before 30 min of lethal ischemia." | 1.30 | Opening of mitochondrial KATP channel induces early and delayed cardioprotective effect: role of nitric oxide. ( Brown, M; Emani, VR; Krottapalli, K; Kukreja, RC; Ockaili, R; Okubo, S, 1999) |
| "Adenosine has been proposed to be an important mediator of ischemic preconditioning." | 1.29 | A comparison of adenosine-induced cardioprotection and ischemic preconditioning in dogs. Efficacy, time course, and role of KATP channels. ( Gross, GJ; Yao, Z, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 18 (24.32) | 18.2507 |
| 2000's | 49 (66.22) | 29.6817 |
| 2010's | 7 (9.46) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kai, Z | 1 |
| Yongbo, W | 1 |
| Lin, Z | 1 |
| Jie, G | 1 |
| Daoqun, J | 1 |
| Zhiqiang, C | 1 |
| Jiang, JJ | 1 |
| Li, C | 2 |
| Li, H | 2 |
| Zhang, L | 1 |
| Lin, ZH | 1 |
| Fu, BJ | 1 |
| Zeng, YM | 1 |
| Donato, M | 1 |
| Goyeneche, MA | 1 |
| Garces, M | 1 |
| Marchini, T | 1 |
| Pérez, V | 1 |
| Del Mauro, J | 1 |
| Höcht, C | 1 |
| Rodríguez, M | 1 |
| Evelson, P | 1 |
| Gelpi, RJ | 1 |
| Baharvand, B | 1 |
| Dehaj, ME | 1 |
| Rasoulian, B | 1 |
| Namdari, M | 1 |
| Shikhani, Y | 1 |
| Kiani, AA | 1 |
| Ye, Y | 1 |
| Lin, Y | 1 |
| Perez-Polo, JR | 1 |
| Birnbaum, Y | 1 |
| Piao, CS | 1 |
| Gao, S | 1 |
| Lee, GH | 1 |
| Kim, DS | 1 |
| Park, BH | 1 |
| Chae, SW | 1 |
| Chae, HJ | 1 |
| Kim, SH | 1 |
| Song, DK | 1 |
| Jang, Y | 1 |
| Kim, JH | 1 |
| Chun, KJ | 1 |
| Lee, D | 1 |
| Xu, Z | 1 |
| Iwasa, M | 1 |
| Kobayashi, H | 1 |
| Yasuda, S | 1 |
| Kawamura, I | 1 |
| Sumi, S | 1 |
| Yamada, Y | 1 |
| Shiraki, T | 1 |
| Yamaki, T | 1 |
| Ushikoshi, H | 1 |
| Aoyama, T | 1 |
| Nishigaki, K | 1 |
| Takemura, G | 1 |
| Fujiwara, T | 1 |
| Fujiwara, H | 1 |
| Minatoguchi, S | 1 |
| Hatcher, AS | 1 |
| Alderson, JM | 1 |
| Clements-Jewery, H | 1 |
| Hausenloy, DJ | 1 |
| Maddock, HL | 1 |
| Baxter, GF | 2 |
| Yellon, DM | 2 |
| Wang, YP | 1 |
| Maeta, H | 1 |
| Mizoguchi, K | 1 |
| Suzuki, T | 1 |
| Yamashita, Y | 1 |
| Oe, M | 1 |
| Tsuchida, A | 2 |
| Miura, T | 2 |
| Tanno, M | 2 |
| Sakamoto, J | 1 |
| Miki, T | 2 |
| Kuno, A | 2 |
| Matsumoto, T | 1 |
| Ohnuma, Y | 2 |
| Ichikawa, Y | 1 |
| Shimamoto, K | 2 |
| Riess, ML | 2 |
| Camara, AK | 2 |
| Novalija, E | 2 |
| Chen, Q | 2 |
| Rhodes, SS | 1 |
| Stowe, DF | 2 |
| Lim, KH | 1 |
| Javadov, SA | 1 |
| Das, M | 1 |
| Clarke, SJ | 1 |
| Suleiman, MS | 1 |
| Halestrap, AP | 1 |
| Eells, JT | 2 |
| Haist, JV | 1 |
| Hirst, CN | 1 |
| Karmazyn, M | 1 |
| Das, B | 3 |
| Sarkar, C | 3 |
| Lee, S | 1 |
| Yi, KY | 1 |
| Kim, SK | 1 |
| Suh, J | 1 |
| Kim, NJ | 1 |
| Yoo, SE | 1 |
| Lee, BH | 1 |
| Seo, HW | 1 |
| Kim, SO | 1 |
| Lim, H | 1 |
| Clark, JE | 1 |
| Naughton, P | 1 |
| Shurey, S | 1 |
| Green, CJ | 1 |
| Johnson, TR | 1 |
| Mann, BE | 1 |
| Foresti, R | 1 |
| Motterlini, R | 1 |
| Zhu, HF | 1 |
| Dong, JW | 1 |
| Zhu, WZ | 1 |
| Ding, HL | 1 |
| Zhou, ZN | 1 |
| Oldenburg, O | 1 |
| Yang, XM | 1 |
| Krieg, T | 1 |
| Garlid, KD | 2 |
| Cohen, MV | 2 |
| Grover, GJ | 5 |
| Downey, JM | 2 |
| Jones, SP | 1 |
| Greer, JJ | 1 |
| Kakkar, AK | 1 |
| Ware, PD | 1 |
| Turnage, RH | 1 |
| Hicks, M | 1 |
| van Haperen, R | 1 |
| de Crom, R | 1 |
| Kawashima, S | 1 |
| Yokoyama, M | 1 |
| Lefer, DJ | 1 |
| Loubani, M | 1 |
| Hassouna, A | 1 |
| Galiñanes, M | 2 |
| Nayeem, MA | 2 |
| Piriou, V | 1 |
| Chiari, P | 1 |
| Gateau-Roesch, O | 1 |
| Argaud, L | 1 |
| Muntean, D | 1 |
| Salles, D | 1 |
| Loufouat, J | 1 |
| Gueugniaud, PY | 1 |
| Lehot, JJ | 1 |
| Ovize, M | 1 |
| Beresewicz, A | 1 |
| Maczewski, M | 1 |
| Duda, M | 1 |
| Diodato, MD | 1 |
| Shah, NR | 1 |
| Prasad, SM | 1 |
| Gaynor, SL | 1 |
| Lawton, JS | 1 |
| Damiano, RJ | 1 |
| Ritchie, RH | 1 |
| Gordon, JM | 1 |
| Woodman, OL | 1 |
| Cao, AH | 1 |
| Dusting, GJ | 1 |
| Shinmura, K | 1 |
| Tamaki, K | 2 |
| Bolli, R | 1 |
| Zhu, YH | 1 |
| Wang, X | 1 |
| Johansen, D | 1 |
| Ytrehus, K | 1 |
| Mühlfeld, C | 1 |
| Urru, M | 1 |
| Rümelin, R | 1 |
| Mirzaie, M | 1 |
| Schöndube, F | 1 |
| Richter, J | 1 |
| Dörge, H | 1 |
| Gok, S | 1 |
| Vatansever, S | 1 |
| Vural, K | 1 |
| Sekuri, C | 1 |
| Izanli, A | 1 |
| Tezcan, A | 1 |
| Cilaker, S | 1 |
| Sivarajah, A | 1 |
| McDonald, MC | 1 |
| Thiemermann, C | 4 |
| Brennan, JP | 1 |
| Southworth, R | 1 |
| Medina, RA | 1 |
| Davidson, SM | 1 |
| Duchen, MR | 1 |
| Shattock, MJ | 1 |
| Pasdois, P | 1 |
| Beauvoit, B | 1 |
| Tariosse, L | 1 |
| Vinassa, B | 1 |
| Bonoron-Adèle, S | 1 |
| Santos, PD | 1 |
| Gao, H | 1 |
| Chen, L | 1 |
| Yang, HT | 1 |
| McCullough, JR | 1 |
| D'Alonzo, AJ | 2 |
| Sargent, CA | 2 |
| Atwal, KS | 2 |
| Moritani, K | 2 |
| Miyazaki, T | 2 |
| Miyoshi, S | 2 |
| Asanagi, M | 1 |
| Zhao, LS | 1 |
| Mitamura, H | 1 |
| Ogawa, S | 2 |
| Yao, Z | 3 |
| Gross, GJ | 6 |
| Hide, EJ | 3 |
| Ney, P | 1 |
| Piper, J | 2 |
| Vane, JR | 1 |
| Wilde, MW | 1 |
| Dzwonczyk, S | 1 |
| Tuttle, JG | 1 |
| Murray, HN | 1 |
| Atwal, K | 1 |
| Schultz, JE | 1 |
| Qian, YZ | 2 |
| Kukreja, RC | 3 |
| Docherty, JC | 1 |
| Gunter, HE | 1 |
| Kuzio, B | 1 |
| Shoemaker, L | 1 |
| Yang, L | 1 |
| Deslauriers, R | 1 |
| Hoag, JB | 1 |
| D'Angelo, M | 1 |
| Sakamoto, K | 1 |
| Yamazaki, J | 1 |
| Nagao, T | 1 |
| Bethell, HW | 1 |
| Vandenberg, JI | 1 |
| Smith, GA | 1 |
| Grace, AA | 1 |
| Wolk, R | 1 |
| Cobbe, SM | 1 |
| Kane, KA | 1 |
| Hicks, MN | 1 |
| Liu, Y | 1 |
| Sato, T | 2 |
| Seharaseyon, J | 1 |
| Szewczyk, A | 1 |
| O'Rourke, B | 2 |
| Marbán, E | 2 |
| Ockaili, R | 1 |
| Emani, VR | 1 |
| Okubo, S | 1 |
| Brown, M | 1 |
| Krottapalli, K | 1 |
| Tong, J | 1 |
| Tan, X | 1 |
| Shao, Z | 1 |
| Kim, WC | 1 |
| vanden Hoek, TL | 1 |
| Becker, LB | 2 |
| Head, CA | 1 |
| Schumacker, PT | 2 |
| Vanden Hoek, T | 1 |
| Shao, ZH | 1 |
| Li, CQ | 1 |
| Ghosh, S | 1 |
| Standen, NB | 1 |
| Obata, T | 1 |
| Yamanaka, Y | 1 |
| Ito, K | 1 |
| Shigematsu, S | 1 |
| Abe, T | 1 |
| Li, Y | 1 |
| Arita, M | 1 |
| Minners, J | 1 |
| van den Bos, EJ | 1 |
| Schwalb, H | 1 |
| Opie, LH | 1 |
| Sack, MN | 1 |
| Fryer, RM | 1 |
| Hsu, AK | 1 |
| Nagase, H | 1 |
| Headrick, JP | 1 |
| Gauthier, NS | 1 |
| Morrison, R | 1 |
| Matherne, GP | 1 |
| Henry, MM | 1 |
| Baker, JE | 2 |
| Tani, M | 1 |
| Honma, Y | 1 |
| Hasegawa, H | 1 |
| Bajgar, R | 1 |
| Lodge, NJ | 1 |
| Sleph, PG | 1 |
| Darbenzio, RB | 1 |
| Hess, TA | 1 |
| Smith, MA | 1 |
| Paucek, P | 1 |
| Imahashi, K | 1 |
| Nishimura, T | 1 |
| Yoshioka, J | 1 |
| Kusuoka, H | 1 |
| Karanth, KS | 2 |
| Murata, M | 1 |
| Akao, M | 1 |
| Zhang, HY | 1 |
| McPherson, BC | 1 |
| Liu, H | 1 |
| Baman, TS | 1 |
| Rock, P | 1 |
| Tonkovic-Capin, M | 1 |
| Bosnjak, ZJ | 1 |
| Tweddell, JS | 1 |
| Fitzpatrick, CM | 1 |
| Feng, J | 1 |
| Rosenkranz, ER | 1 |
| Auchampach, JA | 1 |
1 review available for 5-hydroxydecanoate and Myocardial Ischemia
| Article | Year |
|---|---|
Mitochondrial ATP-dependent potassium channels. Viable candidate effectors of ischemic preconditioning.
Topics: Animals; Decanoic Acids; Diazoxide; Heart; Hydroxy Acids; Intracellular Membranes; Ischemic Precondi | 1999 |
73 other studies available for 5-hydroxydecanoate and Myocardial Ischemia
| Article | Year |
|---|---|
Exendin-4 attenuates ischemia-induced ventricular arrhythmias in rats.
Topics: Animals; Anti-Arrhythmia Agents; Blood Pressure; Decanoic Acids; Disease Models, Animal; Exenatide; | 2013 |
Sevoflurane postconditioning affects post-ischaemic myocardial mitochondrial ATP-sensitive potassium channel function and apoptosis in ageing rats.
Topics: Aging; Animals; Apoptosis; bcl-2-Associated X Protein; Coronary Circulation; Decanoic Acids; Hemodyn | 2016 |
Myocardial triggers involved in activation of remote ischaemic preconditioning.
Topics: Adenosine Triphosphate; Animals; Decanoic Acids; Heart; Hindlimb; Hydrogen Peroxide; Hydroxy Acids; | 2016 |
Delayed anti-arrhythmic effect of nitroglycerin in anesthetized rats: involvement of CGRP, PKC and mK ATP channels.
Topics: Anesthesia; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Benzophenanthridines; Calcitonin | 2009 |
Oral glyburide, but not glimepiride, blocks the infarct-size limiting effects of pioglitazone.
Topics: Administration, Oral; Animals; Body Weight; Coronary Vessels; Data Interpretation, Statistical; Deca | 2008 |
Sulforaphane protects ischemic injury of hearts through antioxidant pathway and mitochondrial K(ATP) channels.
Topics: Animals; Antioxidants; Atrial Natriuretic Factor; bcl-2-Associated X Protein; Caspase 3; Decanoic Ac | 2010 |
Polyphenol (-)-epigallocatechin gallate during ischemia limits infarct size via mitochondrial K(ATP) channel activation in isolated rat hearts.
Topics: Animals; Anti-Arrhythmia Agents; Antioxidants; Catechin; Decanoic Acids; Glyburide; Heart; Hemodynam | 2010 |
Antidiabetic drug voglibose is protective against ischemia-reperfusion injury through glucagon-like peptide 1 receptors and the phosphoinositide 3-kinase-Akt-endothelial nitric oxide synthase pathway in rabbits.
Topics: alpha-Glucosidases; Animals; Arginine; Decanoic Acids; Glucagon-Like Peptide 1; Glucagon-Like Peptid | 2010 |
Mitochondrial uncoupling agents trigger ventricular fibrillation in isolated rat hearts.
Topics: 2,4-Dinitrophenol; Adenosine Triphosphate; Animals; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cyclo | 2011 |
Inhibiting mitochondrial permeability transition pore opening: a new paradigm for myocardial preconditioning?
Topics: Adenosine; Analysis of Variance; Animals; Atractyloside; Calcineurin Inhibitors; Cyclosporine; Decan | 2002 |
Intestinal ischemia preconditions myocardium: role of protein kinase C and mitochondrial K(ATP) channel.
Topics: Alkaloids; Analysis of Variance; Animals; Benzophenanthridines; Blood Pressure; Decanoic Acids; Enzy | 2002 |
Infarct size limitation by nicorandil: roles of mitochondrial K(ATP) channels, sarcolemmal K(ATP) channels, and protein kinase C.
Topics: Animals; Benzamides; Decanoic Acids; Enzyme Inhibitors; Glycine; Hemodynamics; Hydroxy Acids; In Vit | 2002 |
Anesthetic preconditioning attenuates mitochondrial Ca2+ overload during ischemia in Guinea pig intact hearts: reversal by 5-hydroxydecanoic acid.
Topics: Anesthetics; Animals; Calcium; Decanoic Acids; Guinea Pigs; Heart Rate; Hydroxy Acids; Ischemic Prec | 2002 |
The effects of ischaemic preconditioning, diazoxide and 5-hydroxydecanoate on rat heart mitochondrial volume and respiration.
Topics: Acyl Coenzyme A; Animals; Decanoic Acids; Diazoxide; Heart; Hydroxy Acids; Ischemic Preconditioning, | 2002 |
Preconditioning with sevoflurane reduces changes in nicotinamide adenine dinucleotide during ischemia-reperfusion in isolated hearts: reversal by 5-hydroxydecanoic acid.
Topics: Anesthetics, Inhalation; Animals; ATP-Binding Cassette Transporters; Blood Pressure; Coronary Circul | 2003 |
Effective protection by NHE-1 inhibition in ischemic and reperfused heart under preconditioning blockade.
Topics: Animals; Anti-Arrhythmia Agents; Decanoic Acids; Diastole; Guanidines; Heart; Hydroxy Acids; In Vitr | 2003 |
Selective mitochondrial KATP channel activation by nicorandil and 3-pyridyl pinacidil results in antiarrhythmic effect in an anesthetized rabbit model of myocardial ischemia/reperfusion.
Topics: Animals; Anti-Arrhythmia Agents; Antioxidants; Arrhythmias, Cardiac; Blood Pressure; Decanoic Acids; | 2003 |
Cardioselective anti-ischemic ATP-sensitive potassium channel (KATP) openers: benzopyranyl indoline and indole analogues.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cardiotonic Agents; Crystallography, X-Ray; Decanoic A | 2003 |
Cardioprotective actions by a water-soluble carbon monoxide-releasing molecule.
Topics: Animals; Carbon Monoxide; Cardiotonic Agents; Cells, Cultured; Decanoic Acids; Disease Models, Anima | 2003 |
ATP-dependent potassium channels involved in the cardiac protection induced by intermittent hypoxia against ischemia/reperfusion injury.
Topics: Animals; Calcium; Decanoic Acids; Glyburide; Heart Ventricles; Hemodynamics; Hydroxy Acids; Hypoxia; | 2003 |
P1075 opens mitochondrial K(ATP) channels and generates reactive oxygen species resulting in cardioprotection of rabbit hearts.
Topics: Animals; Brain Chemistry; Decanoic Acids; Diazoxide; Glyburide; Guanidines; Hydroxy Acids; Ischemic | 2003 |
Endothelial nitric oxide synthase overexpression attenuates myocardial reperfusion injury.
Topics: Alkenes; Animals; Cattle; Decanoic Acids; Echocardiography; Heart; Hemodynamics; Humans; Hydroxy Aci | 2004 |
Delayed preconditioning of the human myocardium: signal transduction and clinical implications.
Topics: Acetylcholine; Aged; Alkaloids; Anisomycin; Antihypertensive Agents; Benzophenanthridines; Culture T | 2004 |
Sublethal simulated ischemia promotes delayed resistance against ischemia via ATP-sensitive (K+) channels in murine myocytes: role of PKC and iNOS.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Cells, Cultured; Decanoic Acids; Enzyme Act | 2004 |
Desflurane-induced preconditioning alters calcium-induced mitochondrial permeability transition.
Topics: Anesthetics, Inhalation; Animals; Calcium; Cyclosporine; Decanoic Acids; Desflurane; Hemodynamics; H | 2004 |
Effect of classic preconditioning and diazoxide on endothelial function and O2- and NO generation in the post-ischemic guinea-pig heart.
Topics: Animals; Benzamides; Decanoic Acids; Diazoxide; Dose-Response Relationship, Drug; Endothelium, Vascu | 2004 |
Donor heart preservation with pinacidil: the role of the mitochondrial K ATP channel.
Topics: Adenosine; Allopurinol; Animals; Benzamides; Cardiotonic Agents; Coronary Circulation; Decanoic Acid | 2004 |
Annexin-1 peptide Anx-1(2-26) protects adult rat cardiac myocytes from cellular injury induced by simulated ischaemia.
Topics: Alkaloids; Analysis of Variance; Animals; Annexin A1; Benzophenanthridines; Cells, Cultured; Creatin | 2005 |
Short-term caloric restriction improves ischemic tolerance independent of opening of ATP-sensitive K+ channels in both young and aged hearts.
Topics: Adenosine Triphosphate; Aging; AMP-Activated Protein Kinases; Animals; Body Weight; Caloric Restrict | 2005 |
Overexpression of heat-shock protein 20 in rat heart myogenic cells confers protection against simulated ischemia/reperfusion injury.
Topics: Adenoviridae; Animals; Apoptosis; Caspase 3; Caspases; Cells, Cultured; Decanoic Acids; HSP20 Heat-S | 2005 |
Exogenous hydrogen sulfide (H2S) protects against regional myocardial ischemia-reperfusion injury--Evidence for a role of K ATP channels.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Cardiac Output; Decanoic Acids; Glyburide; | 2006 |
Myocardial ischemia tolerance in the newborn rat involving opioid receptors and mitochondrial K+ channels.
Topics: Animals; Decanoic Acids; Glucose; Hydroxy Acids; Mannitol; Mitochondria; Myocardial Ischemia; Myocyt | 2006 |
The role of ATP sensitive K+ channels and of nitric oxide synthase on myocardial ischemia/reperfusion-induced apoptosis.
Topics: Animals; Apoptosis; Benzamides; Decanoic Acids; Hydroxy Acids; Immunoenzyme Techniques; In Situ Nick | 2006 |
The production of hydrogen sulfide limits myocardial ischemia and reperfusion injury and contributes to the cardioprotective effects of preconditioning with endotoxin, but not ischemia in the rat.
Topics: Alkynes; Animals; Cardiotonic Agents; Cystathionine gamma-Lyase; Decanoic Acids; Endotoxins; Enzyme | 2006 |
Mitochondrial uncoupling, with low concentration FCCP, induces ROS-dependent cardioprotection independent of KATP channel activation.
Topics: Acetylcysteine; Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Carbonyl Cyanide p-Trifluor | 2006 |
MitoK(ATP)-dependent changes in mitochondrial volume and in complex II activity during ischemic and pharmacological preconditioning of Langendorff-perfused rat heart.
Topics: Adenosine Diphosphate; Animals; Antihypertensive Agents; Cell Respiration; Decanoic Acids; Diazoxide | 2006 |
Activation of alpha1B-adrenoceptors alleviates ischemia/reperfusion injury by limitation of mitochondrial Ca2+ overload in cardiomyocytes.
Topics: Adenosine Triphosphate; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Anima | 2007 |
Cardioprotective profile of the cardiac-selective ATP-sensitive potassium channel opener BMS-180448.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Aorta; Benzopyrans; Cromakalim; Decanoic Ac | 1995 |
Blockade of ATP-sensitive potassium channels by 5-hydroxydecanoate suppresses monophasic action potential shortening during regional myocardial ischemia.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bl | 1994 |
A comparison of adenosine-induced cardioprotection and ischemic preconditioning in dogs. Efficacy, time course, and role of KATP channels.
Topics: Adenosine; Adenosine Triphosphate; Animals; Decanoic Acids; Dogs; Female; Glyburide; Hydroxy Acids; | 1994 |
Reduction by prostaglandin E1 or prostaglandin E0 of myocardial infarct size in the rabbit by activation of ATP-sensitive potassium channels.
Topics: Adenosine Triphosphate; Alprostadil; Animals; Anti-Arrhythmia Agents; Biotransformation; Blood Press | 1995 |
Endothelin-1-induced reduction of myocardial infarct size by activation of ATP-sensitive potassium channels in a rabbit model of myocardial ischaemia and reperfusion.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Arterial Occlusive Diseases; Blood Pressure | 1995 |
Glyburide-reversible cardioprotective effects of calcium-independent phospholipase A2 inhibition in ischemic rat hearts.
Topics: Animals; Anti-Arrhythmia Agents; Calcium; Coronary Circulation; Decanoic Acids; Dose-Response Relati | 1996 |
Limitation of myocardial infarct size in the rabbit by ischaemic preconditioning is abolished by sodium 5-hydroxydecanoate.
Topics: Animals; Decanoic Acids; Hydroxy Acids; Myocardial Infarction; Myocardial Ischemia; Myocardial Reper | 1996 |
Different responses of epicardium and endocardium to KATP channel modulators during regional ischemia.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Decanoic Acids; Dogs; Endocardium; Hydroxy Acids | 1996 |
The ischemia-selective KATP channel antagonist, 5-hydroxydecanoate, blocks ischemic preconditioning in the rat heart.
Topics: Adenosine Triphosphate; Animals; Decanoic Acids; Hemodynamics; Hydroxy Acids; Ischemic Preconditioni | 1997 |
Effects of cromakalim and glibenclamide on myocardial high energy phosphates and intracellular pH during ischemia-reperfusion: 31P NMR studies.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Benzopyrans; Coronary Circulation; Cromakal | 1997 |
ATP-sensitive potassium channel mediates delayed ischemic protection by heat stress in rabbit heart.
Topics: Animals; Anti-Arrhythmia Agents; Blood Pressure; Decanoic Acids; Glyburide; Heart Rate; Heat Stress | 1997 |
5-hydroxydecanoate selectively reduces the initial increase in extracellular K+ in ischemic guinea-pig heart.
Topics: Animals; Cardiovascular Agents; Decanoic Acids; Guinea Pigs; Heart; Hydroxy Acids; In Vitro Techniqu | 1998 |
Changes in ventricular repolarization during acidosis and low-flow ischemia.
Topics: Acidosis; Action Potentials; Adenosine Triphosphate; Animals; Decanoic Acids; Ferrets; Glyburide; He | 1998 |
Relevance of inter- and intraventricular electrical dispersion to arrhythmogenesis in normal and ischaemic rabbit myocardium: a study with cromakalim, 5-hydroxydecanoate and glibenclamide.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Coronary Disease; Cromakal | 1999 |
Opening of mitochondrial KATP channel induces early and delayed cardioprotective effect: role of nitric oxide.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Coronary Vessels; Decanoic Acids; Diazoxide | 1999 |
Role of reactive oxygen species in acetylcholine-induced preconditioning in cardiomyocytes.
Topics: Acetylcholine; Animals; Anti-Arrhythmia Agents; Cardiotonic Agents; Cells, Cultured; Chick Embryo; D | 1999 |
Preconditioning in cardiomyocytes protects by attenuating oxidant stress at reperfusion.
Topics: Animals; Anti-Arrhythmia Agents; Cell Death; Cells, Cultured; Chick Embryo; Decanoic Acids; Hydrogen | 2000 |
Evidence for mitochondrial K ATP channels as effectors of human myocardial preconditioning.
Topics: Analysis of Variance; Cell Membrane; Decanoic Acids; Diazoxide; Dose-Response Relationship, Drug; Gl | 2000 |
Block of cardiac ATP-sensitive K(+) channels reduces hydroxyl radicals in the rat myocardium.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; Cromakalim; Decano | 2000 |
JTV-519, a novel cardioprotective agent, improves the contractile recovery after ischaemia-reperfusion in coronary perfused guinea-pig ventricular muscles.
Topics: Action Potentials; Adenosine Triphosphate; Alkaloids; Animals; Benzophenanthridines; Calcium Channel | 2000 |
Dinitrophenol, cyclosporin A, and trimetazidine modulate preconditioning in the isolated rat heart: support for a mitochondrial role in cardioprotection.
Topics: Animals; Anti-Arrhythmia Agents; Cyclosporine; Decanoic Acids; Dinitrophenols; Enzyme Inhibitors; Ho | 2000 |
Opioid-induced cardioprotection against myocardial infarction and arrhythmias: mitochondrial versus sarcolemmal ATP-sensitive potassium channels.
Topics: Adenosine Triphosphate; Analgesics, Opioid; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; B | 2000 |
Cardioprotection by K(ATP) channels in wild-type hearts and hearts overexpressing A(1)-adenosine receptors.
Topics: Adenosine Triphosphate; Animals; Decanoic Acids; Heart; Hydroxy Acids; In Vitro Techniques; Mice; Mi | 2000 |
Increased mitochondrial K(ATP) channel activity during chronic myocardial hypoxia: is cardioprotection mediated by improved bioenergetics?
Topics: Adaptation, Physiological; Adenosine Triphosphate; Animals; Animals, Newborn; Benzopyrans; Cell Hypo | 2000 |
Direct activation of mitochondrial K(ATP) channels mimics preconditioning but protein kinase C activation is less effective in middle-aged rat hearts.
Topics: Aging; Animals; Anti-Arrhythmia Agents; Creatine Kinase; Decanoic Acids; Diglycerides; Heart; Hydrox | 2001 |
Mitochondrial K(ATP)channel opening during index ischemia and following myocardial reperfusion in ischemic rat hearts.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Decanoic Acids; Heart; Hydroxy Acids; Ion C | 2001 |
Pharmacologic characterization of BMS-191095, a mitochondrial K(ATP) opener with no peripheral vasodilator or cardiac action potential shortening activity.
Topics: Action Potentials; Animals; Benzopyrans; Cardiovascular Agents; Cromakalim; Decanoic Acids; Dose-Res | 2001 |
Role of intracellular Na(+) kinetics in preconditioned rat heart.
Topics: Animals; Decanoic Acids; Diazoxide; Hydroxy Acids; In Vitro Techniques; Intracellular Fluid; Ischemi | 2001 |
Effects of administration of nicorandil or bimakalim prior to and during ischemia or reperfusion on survival rate, ischemia/reperfusion-induced arrhythmias and infarct size in anesthetized rabbits.
Topics: Animals; Antihypertensive Agents; Arrhythmias, Cardiac; Benzopyrans; Blood Gas Analysis; Coronary Di | 2001 |
Mitochondrial ATP-sensitive potassium channels attenuate matrix Ca(2+) overload during simulated ischemia and reperfusion: possible mechanism of cardioprotection.
Topics: Bongkrekic Acid; Calcium; Cell Separation; Cytoprotection; Decanoic Acids; Diazoxide; Dose-Response | 2001 |
Selective mitochondrial K(ATP) channel activation results in antiarrhythmic effect during experimental myocardial ischemia/reperfusion in anesthetized rabbits.
Topics: Anesthesia; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Blood Gas Analysis; Blood Pressur | 2002 |
H(2)O(2) opens mitochondrial K(ATP) channels and inhibits GABA receptors via protein kinase C-epsilon in cardiomyocytes.
Topics: Animals; Calcium Channel Blockers; Chick Embryo; Decanoic Acids; Enzyme Inhibitors; Fluoresceins; Fl | 2002 |
Delayed cardioprotection by isoflurane: role of K(ATP) channels.
Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Benzamides; Cytoprotection; Decanoic Acids; Dose- | 2002 |
Opening of mitochondrial K(ATP) channel occurs downstream of PKC-epsilon activation in the mechanism of preconditioning.
Topics: Adenosine Triphosphate; Animals; Decanoic Acids; Diazoxide; Enzyme Activation; Hemodynamics; Hydroxy | 2002 |
Diazoxide protects the rabbit heart following cardioplegic ischemia.
Topics: Animals; Anti-Arrhythmia Agents; Cardioplegic Solutions; Coronary Circulation; Decanoic Acids; Diast | 2002 |
Blockade of ischaemic preconditioning in dogs by the novel ATP dependent potassium channel antagonist sodium 5-hydroxydecanoate.
Topics: Animals; Benzopyrans; Blood Glucose; Blood Pressure; Coronary Circulation; Coronary Vessels; Decanoi | 1992 |