5-hydroxydecanoate has been researched along with Myocardial Infarction in 99 studies
5-hydroxydecanoic acid: Potassium Channel Blocker; RN refers to parent cpd
Myocardial Infarction: NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of the current study was to determine whether hypercholesterolemia affects the delayed sevoflurane preconditioning against myocardial ischemia-reperfusion (IR) injury and, if so, the underlying mechanism." | 7.78 | Hypercholesterolemia abrogates sevoflurane-induced delayed preconditioning against myocardial infarct in rats by alteration of nitric oxide synthase signaling. ( Chen, G; Ma, LL; Qian, LB; Wang, WN; Yan, M; Yang, MJ; Yu, J; Yu, LN; Zhang, FJ, 2012) |
| "The current study was carried out to determine whether fasudil hydrochloride (fasudil), a Rho-kinase inhibitor, has myocardial postconditioning (PostC) activity under hyperglycemia as well as normoglycemia, and if so, whether the effects could be mediated by mitochondrial ATP-sensitive potassium (m-KATP) channels." | 7.78 | High-dose fasudil preserves postconditioning against myocardial infarction under hyperglycemia in rats: role of mitochondrial KATP channels. ( Cho, S; Higashijima, U; Ichinomiya, T; Maekawa, T; Matsumoto, S; Sumikawa, K, 2012) |
| " The present study examined whether or not cilostazol reduces the myocardial infarct size, and investigated its mechanism in a rabbit model of myocardial infarction." | 7.77 | Cilostazol protects the heart against ischaemia reperfusion injury in a rabbit model of myocardial infarction: focus on adenosine, nitric oxide and mitochondrial ATP-sensitive potassium channels. ( Aoyama, T; Bai, Y; Iwasa, M; Minatoguchi, S; Murakami, H; Nishigaki, K; Sumi, S; Takemura, G; Uno, B; Ushikoshi, H; Yamada, Y, 2011) |
| "The insulin-sensitizing drug pioglitazone has been reported to be protective against myocardial infarction." | 7.75 | Antidiabetic drug pioglitazone protects the heart via activation of PPAR-gamma receptors, PI3-kinase, Akt, and eNOS pathway in a rabbit model of myocardial infarction. ( Fujiwara, H; Fujiwara, T; Iwasa, M; Kawamura, I; Kobayashi, H; Minatoguchi, S; Nagashima, K; Narentuoya, B; Nishigaki, K; Sumi, S; Takemura, G; Ushikoshi, H; Yamaki, T; Yasuda, S, 2009) |
| "We investigated whether (endogenous) hydrogen sulfide (H2S) protects the heart against myocardial ischemia and reperfusion injury." | 7.73 | The production of hydrogen sulfide limits myocardial ischemia and reperfusion injury and contributes to the cardioprotective effects of preconditioning with endotoxin, but not ischemia in the rat. ( McDonald, MC; Sivarajah, A; Thiemermann, C, 2006) |
| " In addition, the myocardial infarct size was significantly smaller in diazoxide-treated acute myocardial infarction rats compared with untreated rats." | 4.31 | Effects of Mitochondrial ATP-Sensitive Potassium Channel in Rats with Acute Myocardial Infarction and Its Association with the AKT/mTOR Pathway. ( Chen, QF; Huang, DL; Huang, Z; Nong, J; Wang, F; Wang, W; Yang, F; Yang, J; Zeng, J; Zeng, Q; Zhang, LD, 2023) |
| "Levosimendan is a positive inotropic drug for the treatment of acute decompensated heart failure (HF)." | 3.81 | Levosimendan exerts anti-inflammatory effects on cardiac myocytes and endothelial cells in vitro. ( Aliabadi, A; Buchberger, E; de Martin, R; Demyanets, S; Gröger, M; Hofer-Warbinek, R; Huber, K; Kastl, SP; Kaun, C; Krychtiuk, KA; Maurer, G; Pisoni, J; Rauscher, S; Speidl, WS; Watzke, L; Wojta, J; Zuckermann, A, 2015) |
| "The aim of the current study was to determine whether hypercholesterolemia affects the delayed sevoflurane preconditioning against myocardial ischemia-reperfusion (IR) injury and, if so, the underlying mechanism." | 3.78 | Hypercholesterolemia abrogates sevoflurane-induced delayed preconditioning against myocardial infarct in rats by alteration of nitric oxide synthase signaling. ( Chen, G; Ma, LL; Qian, LB; Wang, WN; Yan, M; Yang, MJ; Yu, J; Yu, LN; Zhang, FJ, 2012) |
| "The current study was carried out to determine whether fasudil hydrochloride (fasudil), a Rho-kinase inhibitor, has myocardial postconditioning (PostC) activity under hyperglycemia as well as normoglycemia, and if so, whether the effects could be mediated by mitochondrial ATP-sensitive potassium (m-KATP) channels." | 3.78 | High-dose fasudil preserves postconditioning against myocardial infarction under hyperglycemia in rats: role of mitochondrial KATP channels. ( Cho, S; Higashijima, U; Ichinomiya, T; Maekawa, T; Matsumoto, S; Sumikawa, K, 2012) |
| " Compared with the IR-control group, both the LIPC and MIPC groups showed an amelioration of ventricular arrhythmia, reduced myocardial infarct size, increased activities of total superoxide dismutase, manganese-superoxide dismutase (Mn-SOD) and glutathione peroxidase, increased expression of Mn-SOD mRNA and decreased xanthine oxidase activity and malondialdehyde concentration." | 3.77 | Noninvasive delayed limb ischemic preconditioning attenuates myocardial ischemia-reperfusion injury in rats by a mitochondrial K(ATP) channel-dependent mechanism. ( Gao, WZ; Jiao, JJ; Kang, Y; Liu, YX; Lou, JS; Wu, YN; Yu, H; Yuan, HJ; Zhu, XH, 2011) |
| " The present study examined whether or not cilostazol reduces the myocardial infarct size, and investigated its mechanism in a rabbit model of myocardial infarction." | 3.77 | Cilostazol protects the heart against ischaemia reperfusion injury in a rabbit model of myocardial infarction: focus on adenosine, nitric oxide and mitochondrial ATP-sensitive potassium channels. ( Aoyama, T; Bai, Y; Iwasa, M; Minatoguchi, S; Murakami, H; Nishigaki, K; Sumi, S; Takemura, G; Uno, B; Ushikoshi, H; Yamada, Y, 2011) |
| "Polyphenol (-)-epigallocatechin gallate (EGCG), the most abundant catechin of green tea, appears to attenuate myocardial ischemia/reperfusion injury." | 3.76 | Polyphenol (-)-epigallocatechin gallate during ischemia limits infarct size via mitochondrial K(ATP) channel activation in isolated rat hearts. ( Chun, KJ; Jang, Y; Kim, JH; Lee, D; Song, DK; Xu, Z, 2010) |
| "The insulin-sensitizing drug pioglitazone has been reported to be protective against myocardial infarction." | 3.75 | Antidiabetic drug pioglitazone protects the heart via activation of PPAR-gamma receptors, PI3-kinase, Akt, and eNOS pathway in a rabbit model of myocardial infarction. ( Fujiwara, H; Fujiwara, T; Iwasa, M; Kawamura, I; Kobayashi, H; Minatoguchi, S; Nagashima, K; Narentuoya, B; Nishigaki, K; Sumi, S; Takemura, G; Ushikoshi, H; Yamaki, T; Yasuda, S, 2009) |
| "In the present study, we investigated the efficacy of pharmacological postconditioning induced by 17beta-estradiol and the phytoestrogen, genistein, against myocardial infarction induced by increasing durations of coronary artery occlusion (CAO)." | 3.75 | The ceiling effect of pharmacological postconditioning with the phytoestrogen genistein is reversed by the GSK3beta inhibitor SB 216763 [3-(2,4-dichlorophenyl)-4(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione] through mitochondrial ATP-dependent potassium c ( Berdeaux, A; Chenoune, M; Couvreur, N; Ghaleh, B; Pons, S; Tissier, R; Waintraub, X, 2009) |
| "We investigated whether (endogenous) hydrogen sulfide (H2S) protects the heart against myocardial ischemia and reperfusion injury." | 3.73 | The production of hydrogen sulfide limits myocardial ischemia and reperfusion injury and contributes to the cardioprotective effects of preconditioning with endotoxin, but not ischemia in the rat. ( McDonald, MC; Sivarajah, A; Thiemermann, C, 2006) |
| " In the present study, we investigated the effects of administration of non-hypotensive doses of ATP-sensitive K(+) channel (K(ATP)) openers (nicorandil and cromakalim), a specific mitochondrial K(ATP) channel blocker (5-hydroxydecanoate (5-HD)) and a specific sarcolemmal K(ATP) channel blocker (HMR 1883; (1-[5-[2-(5-chloro-o-anisamido)ethyl]-2-methoxyphenyl]sulfonyl-3-methylthiourea) prior to and during coronary occlusion as well as prior to and during post-ischemic reperfusion on survival rate, ischemia-induced and reperfusion-induced arrhythmias and myocardial infarct size in anesthetized albino rabbits." | 3.72 | Mitochondrial K ATP channel activation is important in the antiarrhythmic and cardioprotective effects of non-hypotensive doses of nicorandil and cromakalim during ischemia/reperfusion: a study in an intact anesthetized rabbit model. ( Das, B; Sarkar, C, 2003) |
| "Adenosine-mediated preconditioning is dose-dependent with high level stimulation reducing contractile dysfunction in addition to necrosis." | 3.72 | Adenosine-mediated early preconditioning in mouse: protective signaling and concentration dependent effects. ( Headrick, JP; Peart, J, 2003) |
| "We investigated the effects of administration of non-hypotensive doses of ATP-sensitive K+ channel (K(ATP)) openers (nicorandil and aprikalim), and a specific mitochondrial K(ATP) channel blocker (5-hydroxydecanoate) prior to and during coronary occlusion as well as prior to and during post-ischemic reperfusion on survival rate, ischemia/reperfusion-induced arrhythmias and myocardial infarct size in anesthetized albino rabbits." | 3.71 | Selective mitochondrial K(ATP) channel activation results in antiarrhythmic effect during experimental myocardial ischemia/reperfusion in anesthetized rabbits. ( Das, B; Karanth, KS; Sarkar, C, 2002) |
| "Myocardial infarction was initiated by permanent ligation of the left anterior descending (LAD) coronary artery." | 1.40 | Dodecafluoropentane emulsion elicits cardiac protection against myocardial infarction through an ATP-Sensitive K+ channel dependent mechanism. ( Chen, QM; Larson, DF; Strom, J; Swyers, T; Unger, E; Wilson, D, 2014) |
| "Oxytocin (OXT) pretreatment protects the heart during ischemia-reperfusion injury by activating ATP-dependent potassium (K(ATP)) channels." | 1.38 | Is preconditioning by oxytocin administration mediated by iNOS and/or mitochondrial K(ATP) channel activation in the in vivo anesthetized rabbit heart? ( Das, B; Sarkar, C, 2012) |
| "Sulforaphane is known to be an indirect antioxidant that acts by inducing Nrf2-dependent phase 2 enzymes." | 1.36 | Sulforaphane protects ischemic injury of hearts through antioxidant pathway and mitochondrial K(ATP) channels. ( Chae, HJ; Chae, SW; Gao, S; Kim, DS; Kim, SH; Lee, GH; Park, BH; Piao, CS, 2010) |
| "Myocardial infarction was induced by 30-min coronary occlusion/2-h reperfusion in rat hearts in situ, and infarct size was expressed as a percentage of the area at risk (% IS/AR)." | 1.32 | Mitochondrial KATP channel-dependent and -independent phases of ischemic preconditioning against myocardial infarction in the rat. ( Miki, T; Miura, T; Nozawa, Y; Ohnuma, Y; Shimamoto, K; Yano, T, 2003) |
| "Sevoflurane was washed out for 30 min, and 5-HD for 15 min, before 30-min ischemia and 120-min reperfusion." | 1.32 | Preconditioning with sevoflurane reduces changes in nicotinamide adenine dinucleotide during ischemia-reperfusion in isolated hearts: reversal by 5-hydroxydecanoic acid. ( Camara, AK; Chen, Q; Eells, JT; Novalija, E; Riess, ML; Stowe, DF, 2003) |
| " In a first study to characterize effects of sex and the dose-response profile of estrogen on infarct size, the drug was intravenously administered at 10 or 20 microg/kg." | 1.31 | Cardioprotective effects of 17 beta-estradiol produced by activation ofmitochondrial ATP-sensitive K(+)Channels in canine hearts. ( Lee, TM; Lee, YT; Su, SF; Tsai, CC; Tsai, CH, 2000) |
| "Control animals had an average arrhythmia score of 10." | 1.31 | Opioid-induced cardioprotection against myocardial infarction and arrhythmias: mitochondrial versus sarcolemmal ATP-sensitive potassium channels. ( Fryer, RM; Gross, GJ; Hsu, AK; Nagase, H, 2000) |
| "Isoflurane can reproduce the protection afforded by ischemic preconditioning." | 1.31 | Prevention of isoflurane-induced preconditioning by 5-hydroxydecanoate and gadolinium: possible involvement of mitochondrial adenosine triphosphate-sensitive potassium and stretch-activated channels. ( Annat, G; Bastien, O; Chiari, P; Foëx, P; Knezynski, S; Lehot, JJ; Loufoua, J; Ovize, M; Piriou, V, 2000) |
| "Myocardial infarction was induced by occlusion of the anterior descending coronary artery for 60 min and reperfusion for 270 min." | 1.31 | Mitochondrial ATP dependent potassium channels mediate non-ischemic preconditioning by tachycardia in dogs. ( Domenech, R; Macho, P; Sánchez, G; Schwarze, H; Solis, E, 2001) |
| "Pretreatment with diazoxide (100 microM) with a 10-min washout period reduced %IS/LV to 7." | 1.31 | Critical timing of mitochondrial K(ATP) channel opening for enhancement of myocardial tolerance against infarction. ( Genda, S; Kuno, A; Matsumoto, T; Miki, T; Miura, T; Nozawa, Y; Shimamoto, K; Tanno, M; Tsuchida, A, 2001) |
| "Diazoxide (1 mg/kg) was administered either 30 min (for EP) or 24 h (DP) before 30 min of lethal ischemia." | 1.30 | Opening of mitochondrial KATP channel induces early and delayed cardioprotective effect: role of nitric oxide. ( Brown, M; Emani, VR; Krottapalli, K; Kukreja, RC; Ockaili, R; Okubo, S, 1999) |
| "Adenosine has been proposed to be an important mediator of ischemic preconditioning." | 1.29 | A comparison of adenosine-induced cardioprotection and ischemic preconditioning in dogs. Efficacy, time course, and role of KATP channels. ( Gross, GJ; Yao, Z, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 14 (14.14) | 18.2507 |
| 2000's | 62 (62.63) | 29.6817 |
| 2010's | 21 (21.21) | 24.3611 |
| 2020's | 2 (2.02) | 2.80 |
| Authors | Studies |
|---|---|
| Maslov, LN | 2 |
| Sementsov, AS | 1 |
| Naryzhnaya, NV | 1 |
| Derkachev, IA | 1 |
| Fu, F | 1 |
| Gusakova, SV | 1 |
| Sarybaev, A | 1 |
| Zeng, Q | 1 |
| Zhang, LD | 1 |
| Chen, QF | 1 |
| Wang, W | 1 |
| Huang, Z | 1 |
| Huang, DL | 1 |
| Wang, F | 1 |
| Yang, F | 1 |
| Nong, J | 1 |
| Yang, J | 1 |
| Zeng, J | 1 |
| Csonka, C | 1 |
| Kupai, K | 1 |
| Bencsik, P | 1 |
| Görbe, A | 1 |
| Pálóczi, J | 1 |
| Zvara, A | 1 |
| Puskás, LG | 1 |
| Csont, T | 1 |
| Ferdinandy, P | 1 |
| Krychtiuk, KA | 1 |
| Watzke, L | 1 |
| Kaun, C | 1 |
| Buchberger, E | 1 |
| Hofer-Warbinek, R | 1 |
| Demyanets, S | 1 |
| Pisoni, J | 1 |
| Kastl, SP | 1 |
| Rauscher, S | 1 |
| Gröger, M | 1 |
| Aliabadi, A | 1 |
| Zuckermann, A | 1 |
| Maurer, G | 1 |
| de Martin, R | 1 |
| Huber, K | 1 |
| Wojta, J | 1 |
| Speidl, WS | 1 |
| Strom, J | 1 |
| Swyers, T | 1 |
| Wilson, D | 1 |
| Unger, E | 1 |
| Chen, QM | 1 |
| Larson, DF | 1 |
| Donato, M | 1 |
| Goyeneche, MA | 1 |
| Garces, M | 1 |
| Marchini, T | 1 |
| Pérez, V | 1 |
| Del Mauro, J | 1 |
| Höcht, C | 1 |
| Rodríguez, M | 1 |
| Evelson, P | 1 |
| Gelpi, RJ | 1 |
| Baharvand, B | 1 |
| Dehaj, ME | 1 |
| Rasoulian, B | 1 |
| Namdari, M | 1 |
| Shikhani, Y | 1 |
| Kiani, AA | 1 |
| Ye, Y | 1 |
| Lin, Y | 1 |
| Perez-Polo, JR | 1 |
| Birnbaum, Y | 1 |
| Murozono, Y | 1 |
| Takahashi, N | 1 |
| Shinohara, T | 1 |
| Ooie, T | 1 |
| Teshima, Y | 1 |
| Hara, M | 1 |
| Saikawa, T | 1 |
| Yoshimatsu, H | 1 |
| Yasuda, S | 3 |
| Kobayashi, H | 3 |
| Iwasa, M | 4 |
| Kawamura, I | 2 |
| Sumi, S | 4 |
| Narentuoya, B | 1 |
| Yamaki, T | 3 |
| Ushikoshi, H | 4 |
| Nishigaki, K | 4 |
| Nagashima, K | 1 |
| Takemura, G | 7 |
| Fujiwara, T | 3 |
| Fujiwara, H | 5 |
| Minatoguchi, S | 7 |
| Couvreur, N | 1 |
| Tissier, R | 1 |
| Pons, S | 1 |
| Chenoune, M | 1 |
| Waintraub, X | 1 |
| Berdeaux, A | 1 |
| Ghaleh, B | 1 |
| Piao, CS | 1 |
| Gao, S | 1 |
| Lee, GH | 1 |
| Kim, DS | 1 |
| Park, BH | 1 |
| Chae, SW | 1 |
| Chae, HJ | 1 |
| Kim, SH | 1 |
| Cui, X | 1 |
| Wang, H | 1 |
| Guo, H | 1 |
| Wang, C | 1 |
| Ao, H | 1 |
| Liu, X | 1 |
| Tan, YZ | 1 |
| Song, DK | 1 |
| Jang, Y | 1 |
| Kim, JH | 1 |
| Chun, KJ | 1 |
| Lee, D | 1 |
| Xu, Z | 1 |
| Yamada, Y | 3 |
| Shiraki, T | 1 |
| Aoyama, T | 3 |
| Parra, VM | 1 |
| Macho, P | 3 |
| Domenech, RJ | 1 |
| Hattori, A | 1 |
| Panneerselvam, M | 1 |
| Tsutsumi, YM | 1 |
| Bonds, JA | 1 |
| Horikawa, YT | 1 |
| Saldana, M | 1 |
| Dalton, ND | 1 |
| Head, BP | 1 |
| Patel, PM | 1 |
| Roth, DM | 1 |
| Patel, HH | 2 |
| Wu, YN | 1 |
| Yu, H | 1 |
| Zhu, XH | 1 |
| Yuan, HJ | 1 |
| Kang, Y | 1 |
| Jiao, JJ | 1 |
| Gao, WZ | 1 |
| Liu, YX | 1 |
| Lou, JS | 1 |
| Nuñez, IP | 1 |
| Fantinelli, J | 1 |
| Arbeláez, LF | 1 |
| Mosca, SM | 1 |
| Bai, Y | 1 |
| Murakami, H | 1 |
| Uno, B | 1 |
| Zhang, FJ | 1 |
| Ma, LL | 1 |
| Wang, WN | 1 |
| Qian, LB | 1 |
| Yang, MJ | 1 |
| Yu, J | 1 |
| Chen, G | 1 |
| Yu, LN | 1 |
| Yan, M | 1 |
| Ichinomiya, T | 1 |
| Cho, S | 1 |
| Higashijima, U | 1 |
| Matsumoto, S | 1 |
| Maekawa, T | 1 |
| Sumikawa, K | 1 |
| Das, B | 3 |
| Sarkar, C | 3 |
| Yoshida, A | 1 |
| Asanuma, H | 2 |
| Sasaki, H | 1 |
| Sanada, S | 2 |
| Yamazaki, S | 1 |
| Asano, Y | 1 |
| Shinozaki, Y | 2 |
| Mori, H | 2 |
| Shimouchi, A | 1 |
| Sano, M | 1 |
| Asakura, M | 2 |
| Minamino, T | 1 |
| Takashima, S | 2 |
| Sugimachi, M | 1 |
| Mochizuki, N | 1 |
| Kitakaze, M | 2 |
| Ben Gal, T | 1 |
| Lev, EI | 1 |
| Andersen, A | 1 |
| Povlsen, JA | 1 |
| Bøtker, HE | 1 |
| Nielsen-Kudsk, JE | 1 |
| Wang, ZF | 1 |
| Wang, NP | 1 |
| Harmouche, S | 1 |
| Philip, T | 1 |
| Pang, XF | 1 |
| Bai, F | 1 |
| Zhao, ZQ | 1 |
| Smith, RM | 1 |
| Suleman, N | 1 |
| McCarthy, J | 1 |
| Sack, MN | 1 |
| Domenech, R | 2 |
| Schwarze, H | 2 |
| Sánchez, G | 2 |
| Neckár, J | 1 |
| Szárszoi, O | 1 |
| Koten, L | 1 |
| Papousek, F | 1 |
| Ost'ádal, B | 1 |
| Grover, GJ | 3 |
| Kolár, F | 1 |
| Yue, Y | 2 |
| Qin, Q | 1 |
| Cohen, MV | 8 |
| Downey, JM | 8 |
| Critz, SD | 2 |
| Schwartz, LM | 1 |
| Welch, TS | 1 |
| Crago, MS | 1 |
| Shimizu, Y | 1 |
| Hashimoto, K | 2 |
| Uno, Y | 3 |
| Arai, M | 3 |
| Wang, N | 3 |
| Chen, X | 2 |
| Lu, C | 2 |
| Shimomura, M | 1 |
| Nozawa, Y | 2 |
| Miura, T | 3 |
| Miki, T | 4 |
| Ohnuma, Y | 1 |
| Yano, T | 1 |
| Shimamoto, K | 3 |
| Riess, ML | 1 |
| Novalija, E | 1 |
| Camara, AK | 1 |
| Eells, JT | 2 |
| Chen, Q | 1 |
| Stowe, DF | 1 |
| Iliodromitis, EK | 1 |
| Cokkinos, P | 1 |
| Zoga, A | 1 |
| Steliou, I | 1 |
| Vrettou, AR | 1 |
| Kremastinos, DT | 1 |
| Misao, Y | 1 |
| Lishmanov, YB | 1 |
| Solenkova, NV | 1 |
| Gross, GJ | 9 |
| Stefano, GB | 1 |
| Tam, SW | 1 |
| Peart, J | 1 |
| Headrick, JP | 1 |
| Müllenheim, J | 2 |
| Ebel, D | 1 |
| Bauer, M | 1 |
| Otto, F | 1 |
| Heinen, A | 2 |
| Frässdorf, J | 2 |
| Preckel, B | 2 |
| Schlack, W | 2 |
| Oldenburg, O | 1 |
| Yang, XM | 5 |
| Krieg, T | 2 |
| Garlid, KD | 1 |
| Jones, SP | 1 |
| Greer, JJ | 1 |
| Kakkar, AK | 1 |
| Ware, PD | 1 |
| Turnage, RH | 1 |
| Hicks, M | 1 |
| van Haperen, R | 1 |
| de Crom, R | 1 |
| Kawashima, S | 1 |
| Yokoyama, M | 1 |
| Lefer, DJ | 1 |
| Proctor, JB | 1 |
| Cui, L | 1 |
| Gross, ER | 2 |
| Peart, JN | 1 |
| Hsu, AK | 3 |
| Przyklenk, K | 1 |
| Maynard, M | 1 |
| Whittaker, P | 1 |
| Brown, DA | 1 |
| Chicco, AJ | 1 |
| Jew, KN | 1 |
| Johnson, MS | 1 |
| Lynch, JM | 1 |
| Watson, PA | 1 |
| Moore, RL | 1 |
| Wajima, T | 1 |
| Shimizu, S | 1 |
| Hiroi, T | 1 |
| Ishii, M | 1 |
| Kiuchi, Y | 1 |
| Sivarajah, A | 1 |
| McDonald, MC | 1 |
| Thiemermann, C | 6 |
| Xu, D | 1 |
| Li, Y | 1 |
| Wang, J | 1 |
| Davey, AK | 1 |
| Zhang, S | 1 |
| Evans, AM | 1 |
| Penna, C | 1 |
| Mancardi, D | 1 |
| Rastaldo, R | 2 |
| Losano, G | 1 |
| Pagliaro, P | 1 |
| Colantuono, G | 1 |
| Tiravanti, EA | 1 |
| Di Venosa, N | 1 |
| Cazzato, A | 1 |
| Cagiano, R | 1 |
| D'Agostino, D | 1 |
| Federici, A | 1 |
| Fiore, T | 1 |
| Chen, Z | 1 |
| Li, T | 1 |
| Zhang, B | 1 |
| Lucchinetti, E | 1 |
| Jamnicki, M | 1 |
| Fischer, G | 1 |
| Zaugg, M | 1 |
| Lee, SH | 1 |
| Yang, MK | 1 |
| Lim, JH | 1 |
| Seo, HW | 1 |
| Yi, KY | 1 |
| Yoo, SE | 1 |
| Lee, BH | 1 |
| Won, HS | 1 |
| Lee, CS | 1 |
| Choi, WS | 1 |
| Shin, HS | 1 |
| Ji, Y | 1 |
| Pang, QF | 1 |
| Xu, G | 1 |
| Wang, L | 1 |
| Wang, JK | 1 |
| Zeng, YM | 1 |
| Yao, Z | 2 |
| Hide, EJ | 3 |
| Ney, P | 1 |
| Piper, J | 2 |
| Vane, JR | 1 |
| Friedrichs, GS | 1 |
| Abreu, JN | 1 |
| Black, SC | 1 |
| Chi, L | 1 |
| Lucchesi, BR | 1 |
| Bugge, E | 2 |
| Ytrehus, K | 2 |
| Schultz, JE | 1 |
| Qian, YZ | 3 |
| Kukreja, RC | 5 |
| Hoag, JB | 2 |
| Nayeem, MA | 1 |
| D'Angelo, M | 1 |
| Janin, Y | 1 |
| Elliott, GT | 1 |
| Zacharowski, K | 2 |
| Olbrich, A | 1 |
| Baxter, GF | 1 |
| Yellon, DM | 1 |
| Ockaili, R | 1 |
| Emani, VR | 1 |
| Okubo, S | 1 |
| Brown, M | 1 |
| Krottapalli, K | 1 |
| Fryer, RM | 2 |
| Henry, MM | 1 |
| Toller, WG | 1 |
| Kersten, JR | 2 |
| Pagel, PS | 2 |
| Warltier, DC | 2 |
| Lee, TM | 2 |
| Su, SF | 2 |
| Tsai, CC | 1 |
| Lee, YT | 1 |
| Tsai, CH | 2 |
| Munch-Ellingsen, J | 1 |
| Løkebø, JE | 1 |
| Jonassen, AK | 1 |
| Ravingerová, T | 1 |
| Nagase, H | 1 |
| Piriou, V | 1 |
| Chiari, P | 1 |
| Knezynski, S | 1 |
| Bastien, O | 1 |
| Loufoua, J | 1 |
| Lehot, JJ | 1 |
| Foëx, P | 1 |
| Annat, G | 1 |
| Ovize, M | 1 |
| Pain, T | 1 |
| Nakano, A | 1 |
| Liu, GS | 2 |
| Heusch, G | 3 |
| Nakae, I | 1 |
| Takaoka, A | 1 |
| Mitsunami, K | 1 |
| Yabe, T | 1 |
| Ito, M | 1 |
| Matsumoto, T | 2 |
| Omura, T | 1 |
| Yokohama, H | 1 |
| Kinoshita, M | 1 |
| Takano, H | 2 |
| Tang, XL | 2 |
| Bolli, R | 2 |
| Hale, SL | 1 |
| Kloner, RA | 1 |
| Kita, H | 1 |
| Genda, S | 2 |
| Tanno, M | 2 |
| Fukuma, T | 1 |
| Harada, K | 1 |
| Ogita, H | 1 |
| Node, K | 1 |
| Sakata, Y | 1 |
| Kuzuya, T | 1 |
| Hori, M | 1 |
| Solis, E | 1 |
| Black, RG | 1 |
| Kodani, E | 1 |
| Yang, Z | 1 |
| Bhattacharya, S | 1 |
| Auchampach, JA | 1 |
| Ockaili, RA | 1 |
| Bhargava, P | 1 |
| Thämer, V | 1 |
| Hashimoto, Y | 1 |
| Chen, XH | 1 |
| Tsuchida, A | 1 |
| Kuno, A | 1 |
| Krenz, M | 1 |
| Baines, CP | 1 |
| Chatterjee, PK | 1 |
| Suzuki, M | 1 |
| Sasaki, N | 1 |
| Sakamoto, N | 1 |
| Ohmoto-Sekine, Y | 1 |
| Tamagawa, M | 1 |
| Seino, S | 1 |
| Marbán, E | 1 |
| Nakaya, H | 1 |
| Karanth, KS | 1 |
| Chou, TF | 1 |
| Krolikowski, JG | 1 |
| Kehl, F | 1 |
| Mraovic, B | 1 |
| Tonkovic-Capin, M | 1 |
| Bosnjak, ZJ | 1 |
| Tweddell, JS | 1 |
| Fitzpatrick, CM | 1 |
| Baker, JE | 1 |
| Sleph, PG | 1 |
| Dzwonczyk, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Sodium Bicarbonate to Treat Severe Acidosis in the Critically Ill : A Multiple Center Randomized Clinical Trial (BICAR-ICU)[NCT02476253] | Phase 3 | 400 participants (Anticipated) | Interventional | 2015-05-05 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
99 other studies available for 5-hydroxydecanoate and Myocardial Infarction
| Article | Year |
|---|---|
The Role of Mitochondrial K
Topics: Adenosine Triphosphate; Animals; Glyburide; Hypoxia; KATP Channels; Male; Myocardial Infarction; Rat | 2022 |
Effects of Mitochondrial ATP-Sensitive Potassium Channel in Rats with Acute Myocardial Infarction and Its Association with the AKT/mTOR Pathway.
Topics: Animals; Diazoxide; Mammals; Myocardial Infarction; Myocytes, Cardiac; Proto-Oncogene Proteins c-akt | 2023 |
Cholesterol-enriched diet inhibits cardioprotection by ATP-sensitive K+ channel activators cromakalim and diazoxide.
Topics: Adenosine Triphosphate; Animals; Cardiotonic Agents; Cholesterol, Dietary; Cromakalim; Decanoic Acid | 2014 |
Levosimendan exerts anti-inflammatory effects on cardiac myocytes and endothelial cells in vitro.
Topics: Anti-Inflammatory Agents; Cell Adhesion; Cells, Cultured; Decanoic Acids; E-Selectin; Enzyme-Linked | 2015 |
Dodecafluoropentane emulsion elicits cardiac protection against myocardial infarction through an ATP-Sensitive K+ channel dependent mechanism.
Topics: Adenosine Triphosphate; Animals; Coronary Vessels; Decanoic Acids; Fluorocarbons; Heart; Hydroxy Aci | 2014 |
Myocardial triggers involved in activation of remote ischaemic preconditioning.
Topics: Adenosine Triphosphate; Animals; Decanoic Acids; Heart; Hindlimb; Hydrogen Peroxide; Hydroxy Acids; | 2016 |
Delayed anti-arrhythmic effect of nitroglycerin in anesthetized rats: involvement of CGRP, PKC and mK ATP channels.
Topics: Anesthesia; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Benzophenanthridines; Calcitonin | 2009 |
Oral glyburide, but not glimepiride, blocks the infarct-size limiting effects of pioglitazone.
Topics: Administration, Oral; Animals; Body Weight; Coronary Vessels; Data Interpretation, Statistical; Deca | 2008 |
Hyperthermia-induced cardioprotection is potentiated by ischemic postconditioning in rats.
Topics: Androstadienes; Animals; Anti-Arrhythmia Agents; Decanoic Acids; Hydroxy Acids; Hyperthermia, Induce | 2009 |
Antidiabetic drug pioglitazone protects the heart via activation of PPAR-gamma receptors, PI3-kinase, Akt, and eNOS pathway in a rabbit model of myocardial infarction.
Topics: Androstadienes; Anilides; Animals; Blood Glucose; Blotting, Western; Decanoic Acids; Disease Models, | 2009 |
The ceiling effect of pharmacological postconditioning with the phytoestrogen genistein is reversed by the GSK3beta inhibitor SB 216763 [3-(2,4-dichlorophenyl)-4(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione] through mitochondrial ATP-dependent potassium c
Topics: Animals; Anti-Arrhythmia Agents; Blood Pressure; Decanoic Acids; Estradiol; Genistein; Glycogen Synt | 2009 |
Sulforaphane protects ischemic injury of hearts through antioxidant pathway and mitochondrial K(ATP) channels.
Topics: Animals; Antioxidants; Atrial Natriuretic Factor; bcl-2-Associated X Protein; Caspase 3; Decanoic Ac | 2010 |
Transplantation of mesenchymal stem cells preconditioned with diazoxide, a mitochondrial ATP-sensitive potassium channel opener, promotes repair of myocardial infarction in rats.
Topics: Animals; Apoptosis; Cell Count; Cell Survival; Collagen; Cytochromes c; Cytoprotection; Decanoic Aci | 2010 |
Polyphenol (-)-epigallocatechin gallate during ischemia limits infarct size via mitochondrial K(ATP) channel activation in isolated rat hearts.
Topics: Animals; Anti-Arrhythmia Agents; Antioxidants; Catechin; Decanoic Acids; Glyburide; Heart; Hemodynam | 2010 |
Antidiabetic drug voglibose is protective against ischemia-reperfusion injury through glucagon-like peptide 1 receptors and the phosphoinositide 3-kinase-Akt-endothelial nitric oxide synthase pathway in rabbits.
Topics: alpha-Glucosidases; Animals; Arginine; Decanoic Acids; Glucagon-Like Peptide 1; Glucagon-Like Peptid | 2010 |
Late cardiac preconditioning by exercise in dogs is mediated by mitochondrial potassium channels.
Topics: Adenosine Triphosphate; Animals; Decanoic Acids; Dogs; Hydroxy Acids; Ischemic Preconditioning, Myoc | 2010 |
Postconditioning effect of granulocyte colony-stimulating factor is mediated through activation of risk pathway and opening of the mitochondrial KATP channels.
Topics: Androstadienes; Animals; Decanoic Acids; Extracellular Signal-Regulated MAP Kinases; Glycogen Syntha | 2010 |
Dark chocolate receptors: epicatechin-induced cardiac protection is dependent on delta-opioid receptor stimulation.
Topics: Animals; Cacao; Catechin; Decanoic Acids; Dose-Response Relationship, Drug; Hydroxy Acids; Male; Mic | 2010 |
Noninvasive delayed limb ischemic preconditioning attenuates myocardial ischemia-reperfusion injury in rats by a mitochondrial K(ATP) channel-dependent mechanism.
Topics: Animals; Arrhythmias, Cardiac; Decanoic Acids; Glutathione Peroxidase; Hydroxy Acids; Ischemic Preco | 2011 |
Mitochondrial KATP channels participate in the limitation of infarct size by cariporide.
Topics: Animals; Calcium; Cardiotonic Agents; Decanoic Acids; Diazoxide; Disease Models, Animal; Guanidines; | 2011 |
Cilostazol protects the heart against ischaemia reperfusion injury in a rabbit model of myocardial infarction: focus on adenosine, nitric oxide and mitochondrial ATP-sensitive potassium channels.
Topics: Adenosine; Animals; Cardiotonic Agents; Cilostazol; Decanoic Acids; Disease Models, Animal; Drug Eva | 2011 |
Hypercholesterolemia abrogates sevoflurane-induced delayed preconditioning against myocardial infarct in rats by alteration of nitric oxide synthase signaling.
Topics: Amidines; Anesthetics, Inhalation; Animals; Anti-Arrhythmia Agents; bcl-Associated Death Protein; Be | 2012 |
High-dose fasudil preserves postconditioning against myocardial infarction under hyperglycemia in rats: role of mitochondrial KATP channels.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blood Glucose; Decanoic Acids; Diazoxide; Do | 2012 |
Is preconditioning by oxytocin administration mediated by iNOS and/or mitochondrial K(ATP) channel activation in the in vivo anesthetized rabbit heart?
Topics: Anesthesia; Animals; Decanoic Acids; Electrocardiography; Energy Metabolism; Enzyme Inhibitors; Hear | 2012 |
H(2) mediates cardioprotection via involvements of K(ATP) channels and permeability transition pores of mitochondria in dogs.
Topics: Animals; Apoptosis; Cardiotonic Agents; Decanoic Acids; Dogs; Hydrogen; Hydroxy Acids; In Situ Nick- | 2012 |
Ischemic preconditioning of the right ventricle: a new application for an old concept?.
Topics: Animals; Decanoic Acids; Hydroxy Acids; Ischemic Preconditioning, Myocardial; Male; Mitochondria, He | 2012 |
Ischemic preconditioning reduces right ventricular infarct size through opening of mitochondrial potassium channels.
Topics: Animals; Decanoic Acids; Heart Ventricles; Hydroxy Acids; Ischemic Preconditioning, Myocardial; Male | 2012 |
Postconditioning promotes the cardiac repair through balancing collagen degradation and synthesis after myocardial infarction in rats.
Topics: Animals; Collagen; Decanoic Acids; Fibroblasts; Hydroxy Acids; Interleukin-6; Ischemic Postcondition | 2013 |
Classic ischemic but not pharmacologic preconditioning is abrogated following genetic ablation of the TNFalpha gene.
Topics: Adenosine; Analysis of Variance; Animals; Decanoic Acids; Diazoxide; Hydroxy Acids; Ischemic Precond | 2002 |
Exercise induces early and late myocardial preconditioning in dogs.
Topics: Analysis of Variance; Animals; Decanoic Acids; Dogs; Hydroxy Acids; Ischemic Preconditioning, Myocar | 2002 |
Effects of mitochondrial K(ATP) modulators on cardioprotection induced by chronic high altitude hypoxia in rats.
Topics: Altitude; Analysis of Variance; Animals; Benzopyrans; Chronic Disease; Decanoic Acids; Diazoxide; Hy | 2002 |
The relative order of mK(ATP) channels, free radicals and p38 MAPK in preconditioning's protective pathway in rat heart.
Topics: Animals; Anisomycin; Decanoic Acids; Diazoxide; Enzyme Activators; Enzyme Inhibitors; Free Radical S | 2002 |
Cardioprotection by multiple preconditioning cycles does not require mitochondrial K(ATP) channels in pigs.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Blood Pressure; Cardiotonic Agents; Decanoi | 2002 |
The role of serotonin in ischemic cellular damage and the infarct size-reducing effect of sarpogrelate, a 5-hydroxytryptamine-2 receptor blocker, in rabbit hearts.
Topics: Adenosine Triphosphate; Alkaloids; Animals; Benzophenanthridines; Decanoic Acids; Disease Models, An | 2002 |
Mitochondrial KATP channel-dependent and -independent phases of ischemic preconditioning against myocardial infarction in the rat.
Topics: Adenosine Triphosphate; Animals; Decanoic Acids; Disease Models, Animal; Hemodynamics; Hydroxy Acids | 2003 |
Preconditioning with sevoflurane reduces changes in nicotinamide adenine dinucleotide during ischemia-reperfusion in isolated hearts: reversal by 5-hydroxydecanoic acid.
Topics: Anesthetics, Inhalation; Animals; ATP-Binding Cassette Transporters; Blood Pressure; Coronary Circul | 2003 |
Oral nicorandil recaptures the waned protection from preconditioning in vivo.
Topics: Administration, Oral; Animals; Blood Pressure; Decanoic Acids; Disease Models, Animal; Drug Combinat | 2003 |
Mitochondrial K ATP channel activation is important in the antiarrhythmic and cardioprotective effects of non-hypotensive doses of nicorandil and cromakalim during ischemia/reperfusion: a study in an intact anesthetized rabbit model.
Topics: Analysis of Variance; Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; Arrhythmias, Cardiac | 2003 |
Quinaprilat reduces myocardial infarct size involving nitric oxide production and mitochondrial KATP channel in rabbits.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Anti-Arrhythmia Agents; Decanoic Acids; Heart Ven | 2003 |
Activation of peripheral delta opioid receptors eliminates cardiac electrical instability in a rat model of post-infarction cardiosclerosis via mitochondrial ATP-dependent K+ channels.
Topics: Adenosine Triphosphate; Analgesics, Opioid; Animals; Decanoic Acids; Disease Models, Animal; Drug An | 2003 |
Adenosine-mediated early preconditioning in mouse: protective signaling and concentration dependent effects.
Topics: Adenosine; Adenosine Diphosphate; Alkaloids; Animals; Benzophenanthridines; Calcium Channel Blockers | 2003 |
Sevoflurane confers additional cardioprotection after ischemic late preconditioning in rabbits.
Topics: Anesthetics, Inhalation; Animals; ATP-Binding Cassette Transporters; Blood Pressure; Coronary Vessel | 2003 |
P1075 opens mitochondrial K(ATP) channels and generates reactive oxygen species resulting in cardioprotection of rabbit hearts.
Topics: Animals; Brain Chemistry; Decanoic Acids; Diazoxide; Glyburide; Guanidines; Hydroxy Acids; Ischemic | 2003 |
Endothelial nitric oxide synthase overexpression attenuates myocardial reperfusion injury.
Topics: Alkenes; Animals; Cattle; Decanoic Acids; Echocardiography; Heart; Hemodynamics; Humans; Hydroxy Aci | 2004 |
Multiple, brief coronary occlusions during early reperfusion protect rabbit hearts by targeting cell signaling pathways.
Topics: Animals; Calcium Channel Blockers; Decanoic Acids; Enzyme Inhibitors; Female; Glyburide; Hemodynamic | 2004 |
Sarcolemmal KATP channel triggers delayed ischemic preconditioning in rats.
Topics: Adenosine Triphosphate; Animals; Benzamides; Decanoic Acids; Hemodynamics; Hydroxy Acids; Ischemic P | 2005 |
Reduction of infarct size with D-myo-inositol trisphosphate: role of PI3-kinase and mitochondrial K(ATP) channels.
Topics: Alkaloids; Animals; Benzamides; Benzophenanthridines; Cardiotonic Agents; Chromones; Decanoic Acids; | 2006 |
Cardioprotection afforded by chronic exercise is mediated by the sarcolemmal, and not the mitochondrial, isoform of the KATP channel in the rat.
Topics: Animals; ATP-Binding Cassette Transporters; Benzamides; Calcium; Decanoic Acids; Female; Heart; Hydr | 2005 |
Reduction of myocardial infarct size by tetrahydrobiopterin: possible involvement of mitochondrial KATP channels activation through nitric oxide production.
Topics: Animals; Anti-Arrhythmia Agents; Arginine; Biopterins; Cyclic GMP; Decanoic Acids; Dose-Response Rel | 2006 |
The production of hydrogen sulfide limits myocardial ischemia and reperfusion injury and contributes to the cardioprotective effects of preconditioning with endotoxin, but not ischemia in the rat.
Topics: Alkynes; Animals; Cardiotonic Agents; Cystathionine gamma-Lyase; Decanoic Acids; Endotoxins; Enzyme | 2006 |
The cardioprotective effect of isosteviol on rats with heart ischemia-reperfusion injury.
Topics: Animals; Anti-Arrhythmia Agents; Cardiotonic Agents; Decanoic Acids; Disease Models, Animal; Diterpe | 2007 |
The pH hypothesis of postconditioning: staccato reperfusion reintroduces oxygen and perpetuates myocardial acidosis.
Topics: Acidosis; Alkaloids; Animals; Apoptosis; Benzophenanthridines; Buffers; Carbon Dioxide; Catheterizat | 2007 |
Intermittent activation of bradykinin B2 receptors and mitochondrial KATP channels trigger cardiac postconditioning through redox signaling.
Topics: Acetylcysteine; Adenosine Triphosphate; Animals; Bradykinin; Bradykinin B2 Receptor Antagonists; Cyc | 2007 |
Hyperoxia confers myocardial protection in mechanically ventilated rats through the generation of free radicals and opening of mitochondrial ATP-sensitive potassium channels.
Topics: Acetylcysteine; Animals; Blood Pressure; Coronary Circulation; Decanoic Acids; Disease Models, Anima | 2008 |
Morphine postconditioning protects against reperfusion injury in the isolated rat hearts.
Topics: Analgesics, Opioid; Animals; Anti-Arrhythmia Agents; Cardiotonic Agents; Decanoic Acids; Dose-Respon | 2008 |
Preconditioning by isoflurane retains its protection against ischemia-reperfusion injury in postinfarct remodeled rat hearts.
Topics: Anesthetics, Inhalation; Animals; Cardiotonic Agents; Chromones; Coronary Vessels; Decanoic Acids; D | 2008 |
KR-31762, a novel KATP channel opener, exerts cardioprotective effects by opening SarcKATP channels in rat models of ischemia/reperfusion-induced heart injury.
Topics: Animals; Aorta; Benzopyrans; Cardiotonic Agents; Decanoic Acids; Disease Models, Animal; Dose-Respon | 2008 |
Exogenous hydrogen sulfide postconditioning protects isolated rat hearts against ischemia-reperfusion injury.
Topics: Animals; Blood Pressure; Buffers; Coronary Circulation; Creatine Kinase; Decanoic Acids; Dose-Respon | 2008 |
The ATP-dependent potassium channel: an endogenous cardioprotective mechanism.
Topics: Acetylcholine; Adenosine; Animals; Anti-Arrhythmia Agents; Coronary Disease; Decanoic Acids; Disease | 1994 |
A comparison of adenosine-induced cardioprotection and ischemic preconditioning in dogs. Efficacy, time course, and role of KATP channels.
Topics: Adenosine; Adenosine Triphosphate; Animals; Decanoic Acids; Dogs; Female; Glyburide; Hydroxy Acids; | 1994 |
Reduction by prostaglandin E1 or prostaglandin E0 of myocardial infarct size in the rabbit by activation of ATP-sensitive potassium channels.
Topics: Adenosine Triphosphate; Alprostadil; Animals; Anti-Arrhythmia Agents; Biotransformation; Blood Press | 1995 |
Endothelin-1-induced reduction of myocardial infarct size by activation of ATP-sensitive potassium channels in a rabbit model of myocardial ischaemia and reperfusion.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Arterial Occlusive Diseases; Blood Pressure | 1995 |
Limitation of myocardial infarct size in the rabbit by ischaemic preconditioning is abolished by sodium 5-hydroxydecanoate.
Topics: Animals; Decanoic Acids; Hydroxy Acids; Myocardial Infarction; Myocardial Ischemia; Myocardial Reper | 1996 |
5-hydroxydecanoate fails to attenuate ventricular fibrillation in a conscious canine model of sudden cardiac death.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Blood Pressure; Death, Sudden, Cardiac; Decanoic | 1996 |
Endothelin-1 can reduce infarct size through protein kinase C and KATP channels in the isolated rat heart.
Topics: Alkaloids; Animals; Anti-Arrhythmia Agents; Benzophenanthridines; Bosentan; Coronary Circulation; De | 1996 |
The ischemia-selective KATP channel antagonist, 5-hydroxydecanoate, blocks ischemic preconditioning in the rat heart.
Topics: Adenosine Triphosphate; Animals; Decanoic Acids; Hemodynamics; Hydroxy Acids; Ischemic Preconditioni | 1997 |
ATP-sensitive potassium channel mediates delayed ischemic protection by heat stress in rabbit heart.
Topics: Animals; Anti-Arrhythmia Agents; Blood Pressure; Decanoic Acids; Glyburide; Heart Rate; Heat Stress | 1997 |
Pharmacologic preconditioning with monophosphoryl lipid A is abolished by 5-hydroxydecanoate, a specific inhibitor of the K(ATP) channel.
Topics: Adenosine Triphosphate; Animals; Decanoic Acids; Hemodynamics; Hydroxy Acids; Ischemic Preconditioni | 1998 |
Reduction of myocardial injury by the EP3 receptor agonist TEI-3356. Role of protein kinase C and of K(ATP)-channels.
Topics: Adenosine Triphosphate; Alkaloids; Animals; Anti-Arrhythmia Agents; Benzophenanthridines; Decanoic A | 1999 |
ATP-sensitive K+ channels mediate the delayed cardioprotective effect of adenosine A1 receptor activation.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Blood Glucose; Decanoic Acids; Glyburide; H | 1999 |
Opening of mitochondrial KATP channel induces early and delayed cardioprotective effect: role of nitric oxide.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Coronary Vessels; Decanoic Acids; Diazoxide | 1999 |
Ischemic preconditioning in rats: role of mitochondrial K(ATP) channel in preservation of mitochondrial function.
Topics: Adenosine Triphosphate; Animals; Decanoic Acids; Diazoxide; Hemodynamics; Hydroxy Acids; Ischemic Pr | 2000 |
Sarcolemmal and mitochondrial adenosine triphosphate- dependent potassium channels: mechanism of desflurane-induced cardioprotection.
Topics: Adenosine Triphosphate; Anesthetics, Inhalation; Animals; Benzamides; Decanoic Acids; Desflurane; Do | 2000 |
Cardioprotective effects of 17 beta-estradiol produced by activation ofmitochondrial ATP-sensitive K(+)Channels in canine hearts.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Blood Flow Velocity; Decanoic Acids; Dogs; | 2000 |
5-HD abolishes ischemic preconditioning independently of monophasic action potential duration in the heart.
Topics: Action Potentials; Animals; Decanoic Acids; Electrophysiology; Female; Heart; Hemodynamics; Hydroxy | 2000 |
Opioid-induced cardioprotection against myocardial infarction and arrhythmias: mitochondrial versus sarcolemmal ATP-sensitive potassium channels.
Topics: Adenosine Triphosphate; Analgesics, Opioid; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; B | 2000 |
Prevention of isoflurane-induced preconditioning by 5-hydroxydecanoate and gadolinium: possible involvement of mitochondrial adenosine triphosphate-sensitive potassium and stretch-activated channels.
Topics: Adenosine Triphosphate; Animals; Decanoic Acids; Female; Gadolinium; Hemodynamics; Hydroxy Acids; Is | 2000 |
Opening of mitochondrial K(ATP) channels triggers the preconditioned state by generating free radicals.
Topics: Adenosine Triphosphate; Alkaloids; Animals; Benzophenanthridines; Blotting, Western; Decanoic Acids; | 2000 |
Cardioprotective effects of nicorandil in rabbits anaesthetized with halothane: potentiation of ischaemic preconditioning via KATP channels.
Topics: Anesthesia, Inhalation; Anesthetics, Inhalation; Animals; Anti-Arrhythmia Agents; ATP-Binding Casset | 2000 |
Differential role of K(ATP) channels in late preconditioning against myocardial stunning and infarction in rabbits.
Topics: Adenosine Triphosphate; Animals; Decanoic Acids; Diazoxide; Glyburide; Heart; Hemodynamics; Hydroxy | 2000 |
Effect of combined K(ATP) channel activation and Na(+)/H(+) exchange inhibition on infarct size in rabbits.
Topics: Animals; Anti-Arrhythmia Agents; Blood Pressure; Decanoic Acids; Diazoxide; Guanidines; Heart Rate; | 2000 |
Infarct size limitation by bradykinin receptor activation is mediated by the mitochondrial but not by the sarcolemmal K(ATP) channel.
Topics: Analysis of Variance; Animals; Anti-Arrhythmia Agents; Benzamides; Bradykinin; Decanoic Acids; Hemod | 2000 |
Role of mitochondrial and sarcolemmal K(ATP) channels in ischemic preconditioning of the canine heart.
Topics: Adenosine Triphosphate; Animals; Calcium Channel Blockers; Collateral Circulation; Coronary Circulat | 2001 |
Mitochondrial ATP dependent potassium channels mediate non-ischemic preconditioning by tachycardia in dogs.
Topics: Adenosine; Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Blood Flow Velocity; Decanoic Ac | 2001 |
A(1) or A(3) adenosine receptors induce late preconditioning against infarction in conscious rabbits by different mechanisms.
Topics: Adenine; Adenosine; Animals; Binding, Competitive; Cell Line; Consciousness; Decanoic Acids; Humans; | 2001 |
Mitochondrial K(ATP)channel opening during index ischemia and following myocardial reperfusion in ischemic rat hearts.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Decanoic Acids; Heart; Hydroxy Acids; Ion C | 2001 |
Chemical preconditioning with 3-nitropropionic acid in hearts: role of mitochondrial K(ATP) channel.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; Blood Pressure; De | 2001 |
Additive protective effects of late and early ischaemic preconditioning are mediated by the opening of KATP channels in vivo.
Topics: Adenosine Triphosphate; Animals; Decanoic Acids; Hemodynamics; Hydroxy Acids; Ischemic Preconditioni | 2001 |
Acetylcholine, bradykinin, opioids, and phenylephrine, but not adenosine, trigger preconditioning by generating free radicals and opening mitochondrial K(ATP) channels.
Topics: Acetylcholine; Adenosine; Animals; Bradykinin; Decanoic Acids; Free Radical Scavengers; Free Radical | 2001 |
Combination of miglitol, an anti-diabetic drug, and nicorandil markedly reduces myocardial infarct size through opening the mitochondrial K(ATP) channels in rabbits.
Topics: 1-Deoxynojirimycin; Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Blood Pressure; Decanoi | 2001 |
Critical timing of mitochondrial K(ATP) channel opening for enhancement of myocardial tolerance against infarction.
Topics: Animals; Anti-Arrhythmia Agents; Coronary Circulation; Decanoic Acids; Diazoxide; Glyburide; Hydroxy | 2001 |
Acute alcohol-induced protection against infarction in rabbit hearts: differences from and similarities to ischemic preconditioning.
Topics: Adenosine Triphosphate; Alcohols; Alkaloids; Analysis of Variance; Animals; Anti-Arrhythmia Agents; | 2001 |
Delayed preconditioning induced by lipoteichoic acid from B. subtilis and S. aureus is not blocked by administration of 5-hydroxydecanoate.
Topics: Animals; Bacillus subtilis; Decanoic Acids; Hemodynamics; Hydroxy Acids; Ischemic Preconditioning, M | 2002 |
Role of sarcolemmal K(ATP) channels in cardioprotection against ischemia/reperfusion injury in mice.
Topics: Animals; Benzamides; Decanoic Acids; Hydroxy Acids; In Vitro Techniques; Ischemic Preconditioning, M | 2002 |
Selective mitochondrial K(ATP) channel activation results in antiarrhythmic effect during experimental myocardial ischemia/reperfusion in anesthetized rabbits.
Topics: Anesthesia; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Blood Gas Analysis; Blood Pressur | 2002 |
Differential effects of sarcolemmal and mitochondrial K(ATP) channels activated by 17 beta-estradiol on reperfusion arrhythmias and infarct sizes in canine hearts.
Topics: Acute Disease; Animals; Arrhythmias, Cardiac; Benzamides; Blood Pressure; Decanoic Acids; Dogs; Elec | 2002 |
The role of mitochondrial and sarcolemmal K(ATP) channels in canine ethanol-induced preconditioning in vivo.
Topics: Adenosine Triphosphate; Animals; Benzamides; Coronary Circulation; Decanoic Acids; Dogs; Ethanol; He | 2002 |
Delayed cardioprotection by isoflurane: role of K(ATP) channels.
Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Benzamides; Cytoprotection; Decanoic Acids; Dose- | 2002 |
Pharmacologic profile of cromakalim in the treatment of myocardial ischemia in isolated rat hearts and anesthetized dogs.
Topics: Anesthesia; Animals; Anti-Arrhythmia Agents; Benzopyrans; Blood Pressure; Cardiovascular Agents; Cor | 1990 |