5-hydroxydecanoate has been researched along with Heart Disease, Ischemic in 74 studies
5-hydroxydecanoic acid: Potassium Channel Blocker; RN refers to parent cpd
| Excerpt | Relevance | Reference |
|---|---|---|
| "We investigated whether (endogenous) hydrogen sulfide (H2S) protects the heart against myocardial ischemia and reperfusion injury." | 7.73 | The production of hydrogen sulfide limits myocardial ischemia and reperfusion injury and contributes to the cardioprotective effects of preconditioning with endotoxin, but not ischemia in the rat. ( McDonald, MC; Sivarajah, A; Thiemermann, C, 2006) |
| " In the present study, we investigated the effects of the administration of non-hypotensive doses of ATP-sensitive K+ channel (KATP) openers (nicorandil and 3-pyridyl pinacidil), a specific mitochondrial KATP channel blocker (5-hydroxydecanoate) and a specific sarcolemmal KATP channel blocker (HMR 1883; 1-[5-[2-(5-chloro-o-anisamido)ethyl]-2-methoxyphenyl]sulfonyl-3- methylthiourea) prior to and during coronary occlusion, as well as prior to and during post-ischemic reperfusion, on survival rate, ischemia-induced and reperfusion-induced arrhythmias and myocardial infarct size in anesthetized albino rabbits." | 7.72 | Selective mitochondrial KATP channel activation by nicorandil and 3-pyridyl pinacidil results in antiarrhythmic effect in an anesthetized rabbit model of myocardial ischemia/reperfusion. ( Das, B; Sarkar, C, 2003) |
| "We investigated the effects of administration of non-hypotensive doses of ATP-sensitive K+ channel (KATP) openers (nicorandil and bimakalim), and a specific mitochondrial KATP channel blocker (5-hydroxydecanoate) prior to and during coronary occlusion as well as prior to and during post-ischemic reperfusion on survival rate, ischemia-induced and reperfusion-induced arrhythmias and myocardial infarct size in anesthetized albino rabbits." | 7.71 | Effects of administration of nicorandil or bimakalim prior to and during ischemia or reperfusion on survival rate, ischemia/reperfusion-induced arrhythmias and infarct size in anesthetized rabbits. ( Das, B; Karanth, KS; Sarkar, C, 2001) |
| "Hydrogen sulfide (H2S) is a gaseous mediator, produced by the metabolic pathways that regulate tissue concentrations of sulfur-containing amino acids." | 5.33 | Exogenous hydrogen sulfide (H2S) protects against regional myocardial ischemia-reperfusion injury--Evidence for a role of K ATP channels. ( Baxter, GF; Johansen, D; Ytrehus, K, 2006) |
| " The purpose of this study was to investigate the roles of loss of oxidative phosphorylation and activation of the mitochondrial ATP-sensitive K+ channel and permeability transition pore in VF development during myocardial ischemia by using mitochondrial uncoupling agents (carbonyl cyanide m-chlorophenylhydrazone and 2,4-dinitrophenol) and channel blockers (5-hydroxydecanoate and cyclosporine A) at concentrations that have been demonstrated to block the intended targets selectively." | 3.77 | Mitochondrial uncoupling agents trigger ventricular fibrillation in isolated rat hearts. ( Alderson, JM; Clements-Jewery, H; Hatcher, AS, 2011) |
| "Polyphenol (-)-epigallocatechin gallate (EGCG), the most abundant catechin of green tea, appears to attenuate myocardial ischemia/reperfusion injury." | 3.76 | Polyphenol (-)-epigallocatechin gallate during ischemia limits infarct size via mitochondrial K(ATP) channel activation in isolated rat hearts. ( Chun, KJ; Jang, Y; Kim, JH; Lee, D; Song, DK; Xu, Z, 2010) |
| "We investigated whether (endogenous) hydrogen sulfide (H2S) protects the heart against myocardial ischemia and reperfusion injury." | 3.73 | The production of hydrogen sulfide limits myocardial ischemia and reperfusion injury and contributes to the cardioprotective effects of preconditioning with endotoxin, but not ischemia in the rat. ( McDonald, MC; Sivarajah, A; Thiemermann, C, 2006) |
| " In the present study, we investigated the effects of the administration of non-hypotensive doses of ATP-sensitive K+ channel (KATP) openers (nicorandil and 3-pyridyl pinacidil), a specific mitochondrial KATP channel blocker (5-hydroxydecanoate) and a specific sarcolemmal KATP channel blocker (HMR 1883; 1-[5-[2-(5-chloro-o-anisamido)ethyl]-2-methoxyphenyl]sulfonyl-3- methylthiourea) prior to and during coronary occlusion, as well as prior to and during post-ischemic reperfusion, on survival rate, ischemia-induced and reperfusion-induced arrhythmias and myocardial infarct size in anesthetized albino rabbits." | 3.72 | Selective mitochondrial KATP channel activation by nicorandil and 3-pyridyl pinacidil results in antiarrhythmic effect in an anesthetized rabbit model of myocardial ischemia/reperfusion. ( Das, B; Sarkar, C, 2003) |
| " Intravenous injection of protein kinase C inhibitors chelerythrine (5 mg/kg) and staurosporine (50 microg/kg) or a specific mitochondrial K(ATP) channel inhibitor 5-hydroxydecanoate (5 mg/kg) 5 min before sustained myocardial ischemia abolished the preconditioning afforded by intestinal ischemia." | 3.71 | Intestinal ischemia preconditions myocardium: role of protein kinase C and mitochondrial K(ATP) channel. ( Maeta, H; Mizoguchi, K; Oe, M; Suzuki, T; Wang, YP; Yamashita, Y, 2002) |
| "We investigated the effects of administration of non-hypotensive doses of ATP-sensitive K+ channel (KATP) openers (nicorandil and bimakalim), and a specific mitochondrial KATP channel blocker (5-hydroxydecanoate) prior to and during coronary occlusion as well as prior to and during post-ischemic reperfusion on survival rate, ischemia-induced and reperfusion-induced arrhythmias and myocardial infarct size in anesthetized albino rabbits." | 3.71 | Effects of administration of nicorandil or bimakalim prior to and during ischemia or reperfusion on survival rate, ischemia/reperfusion-induced arrhythmias and infarct size in anesthetized rabbits. ( Das, B; Karanth, KS; Sarkar, C, 2001) |
| "We investigated the effects of administration of non-hypotensive doses of ATP-sensitive K+ channel (K(ATP)) openers (nicorandil and aprikalim), and a specific mitochondrial K(ATP) channel blocker (5-hydroxydecanoate) prior to and during coronary occlusion as well as prior to and during post-ischemic reperfusion on survival rate, ischemia/reperfusion-induced arrhythmias and myocardial infarct size in anesthetized albino rabbits." | 3.71 | Selective mitochondrial K(ATP) channel activation results in antiarrhythmic effect during experimental myocardial ischemia/reperfusion in anesthetized rabbits. ( Das, B; Karanth, KS; Sarkar, C, 2002) |
| ", cromakalim, pinacidil) are potent relaxants of smooth muscle, their utility for treating myocardial ischemia may be limited by hypotension." | 3.69 | Cardioprotective profile of the cardiac-selective ATP-sensitive potassium channel opener BMS-180448. ( Atwal, KS; D'Alonzo, AJ; Grover, GJ; McCullough, JR; Sargent, CA, 1995) |
| "The duration of ventricular tachycardia (VT) + VF, the number of VT + VF episodes and the severity of arrhythmias were all significantly reduced by Ex-4 compared to those in myocardial ischemia group (p < 0." | 1.39 | Exendin-4 attenuates ischemia-induced ventricular arrhythmias in rats. ( Daoqun, J; Jie, G; Kai, Z; Lin, Z; Yongbo, W; Zhiqiang, C, 2013) |
| "Treatment with sulforaphane inhibited an increase in the post-ischemic left ventricular end-diastolic pressure (LVEDP) and improved the post-ischemic left ventricular developed pressure (LVDP), +/-dP/dt, and coronary flow as compared with the untreated control hearts." | 1.36 | Sulforaphane protects ischemic injury of hearts through antioxidant pathway and mitochondrial K(ATP) channels. ( Chae, HJ; Chae, SW; Gao, S; Kim, DS; Kim, SH; Lee, GH; Park, BH; Piao, CS, 2010) |
| "Hydrogen sulfide (H2S) is a gaseous mediator, produced by the metabolic pathways that regulate tissue concentrations of sulfur-containing amino acids." | 1.33 | Exogenous hydrogen sulfide (H2S) protects against regional myocardial ischemia-reperfusion injury--Evidence for a role of K ATP channels. ( Baxter, GF; Johansen, D; Ytrehus, K, 2006) |
| "Sevoflurane was washed out for 30 min, and 5-HD for 15 min, before 30-min ischemia and 120-min reperfusion." | 1.32 | Preconditioning with sevoflurane reduces changes in nicotinamide adenine dinucleotide during ischemia-reperfusion in isolated hearts: reversal by 5-hydroxydecanoic acid. ( Camara, AK; Chen, Q; Eells, JT; Novalija, E; Riess, ML; Stowe, DF, 2003) |
| "Pinacidil solutions have been shown to have significant cardioprotective effects." | 1.32 | Donor heart preservation with pinacidil: the role of the mitochondrial K ATP channel. ( Damiano, RJ; Diodato, MD; Gaynor, SL; Lawton, JS; Prasad, SM; Shah, NR, 2004) |
| "Nicorandil is a hybrid of nitrate and a K(ATP) channel opener that activates the sarcK(ATP) and mitoK(ATP) channels." | 1.31 | Infarct size limitation by nicorandil: roles of mitochondrial K(ATP) channels, sarcolemmal K(ATP) channels, and protein kinase C. ( Ichikawa, Y; Kuno, A; Matsumoto, T; Miki, T; Miura, T; Ohnuma, Y; Sakamoto, J; Shimamoto, K; Tanno, M; Tsuchida, A, 2002) |
| "Sevoflurane was washed out for 30 min and 5-HD for 15 min before 30 min of global ischemia and 120 min of reperfusion." | 1.31 | Anesthetic preconditioning attenuates mitochondrial Ca2+ overload during ischemia in Guinea pig intact hearts: reversal by 5-hydroxydecanoic acid. ( Camara, AK; Chen, Q; Novalija, E; Rhodes, SS; Riess, ML; Stowe, DF, 2002) |
| "Control animals had an average arrhythmia score of 10." | 1.31 | Opioid-induced cardioprotection against myocardial infarction and arrhythmias: mitochondrial versus sarcolemmal ATP-sensitive potassium channels. ( Fryer, RM; Gross, GJ; Hsu, AK; Nagase, H, 2000) |
| "Diazoxide pretreatment significantly improved the recovery of LV function and coronary flow compared to control (LVDP: 49 +/- 5* vs." | 1.31 | Diazoxide protects the rabbit heart following cardioplegic ischemia. ( Feng, J; Li, H; Rosenkranz, ER, 2002) |
| "Pre-treatment with cromakalim delayed the time to ischemic contracture (19." | 1.30 | Effects of cromakalim and glibenclamide on myocardial high energy phosphates and intracellular pH during ischemia-reperfusion: 31P NMR studies. ( Deslauriers, R; Docherty, JC; Gunter, HE; Kuzio, B; Shoemaker, L; Yang, L, 1997) |
| "Diazoxide (1 mg/kg) was administered either 30 min (for EP) or 24 h (DP) before 30 min of lethal ischemia." | 1.30 | Opening of mitochondrial KATP channel induces early and delayed cardioprotective effect: role of nitric oxide. ( Brown, M; Emani, VR; Krottapalli, K; Kukreja, RC; Ockaili, R; Okubo, S, 1999) |
| "Adenosine has been proposed to be an important mediator of ischemic preconditioning." | 1.29 | A comparison of adenosine-induced cardioprotection and ischemic preconditioning in dogs. Efficacy, time course, and role of KATP channels. ( Gross, GJ; Yao, Z, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 18 (24.32) | 18.2507 |
| 2000's | 49 (66.22) | 29.6817 |
| 2010's | 7 (9.46) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kai, Z | 1 |
| Yongbo, W | 1 |
| Lin, Z | 1 |
| Jie, G | 1 |
| Daoqun, J | 1 |
| Zhiqiang, C | 1 |
| Jiang, JJ | 1 |
| Li, C | 2 |
| Li, H | 2 |
| Zhang, L | 1 |
| Lin, ZH | 1 |
| Fu, BJ | 1 |
| Zeng, YM | 1 |
| Donato, M | 1 |
| Goyeneche, MA | 1 |
| Garces, M | 1 |
| Marchini, T | 1 |
| Pérez, V | 1 |
| Del Mauro, J | 1 |
| Höcht, C | 1 |
| Rodríguez, M | 1 |
| Evelson, P | 1 |
| Gelpi, RJ | 1 |
| Baharvand, B | 1 |
| Dehaj, ME | 1 |
| Rasoulian, B | 1 |
| Namdari, M | 1 |
| Shikhani, Y | 1 |
| Kiani, AA | 1 |
| Ye, Y | 1 |
| Lin, Y | 1 |
| Perez-Polo, JR | 1 |
| Birnbaum, Y | 1 |
| Piao, CS | 1 |
| Gao, S | 1 |
| Lee, GH | 1 |
| Kim, DS | 1 |
| Park, BH | 1 |
| Chae, SW | 1 |
| Chae, HJ | 1 |
| Kim, SH | 1 |
| Song, DK | 1 |
| Jang, Y | 1 |
| Kim, JH | 1 |
| Chun, KJ | 1 |
| Lee, D | 1 |
| Xu, Z | 1 |
| Iwasa, M | 1 |
| Kobayashi, H | 1 |
| Yasuda, S | 1 |
| Kawamura, I | 1 |
| Sumi, S | 1 |
| Yamada, Y | 1 |
| Shiraki, T | 1 |
| Yamaki, T | 1 |
| Ushikoshi, H | 1 |
| Aoyama, T | 1 |
| Nishigaki, K | 1 |
| Takemura, G | 1 |
| Fujiwara, T | 1 |
| Fujiwara, H | 1 |
| Minatoguchi, S | 1 |
| Hatcher, AS | 1 |
| Alderson, JM | 1 |
| Clements-Jewery, H | 1 |
| Hausenloy, DJ | 1 |
| Maddock, HL | 1 |
| Baxter, GF | 2 |
| Yellon, DM | 2 |
| Wang, YP | 1 |
| Maeta, H | 1 |
| Mizoguchi, K | 1 |
| Suzuki, T | 1 |
| Yamashita, Y | 1 |
| Oe, M | 1 |
| Tsuchida, A | 2 |
| Miura, T | 2 |
| Tanno, M | 2 |
| Sakamoto, J | 1 |
| Miki, T | 2 |
| Kuno, A | 2 |
| Matsumoto, T | 1 |
| Ohnuma, Y | 2 |
| Ichikawa, Y | 1 |
| Shimamoto, K | 2 |
| Riess, ML | 2 |
| Camara, AK | 2 |
| Novalija, E | 2 |
| Chen, Q | 2 |
| Rhodes, SS | 1 |
| Stowe, DF | 2 |
| Lim, KH | 1 |
| Javadov, SA | 1 |
| Das, M | 1 |
| Clarke, SJ | 1 |
| Suleiman, MS | 1 |
| Halestrap, AP | 1 |
| Eells, JT | 2 |
| Haist, JV | 1 |
| Hirst, CN | 1 |
| Karmazyn, M | 1 |
| Das, B | 3 |
| Sarkar, C | 3 |
| Lee, S | 1 |
| Yi, KY | 1 |
| Kim, SK | 1 |
| Suh, J | 1 |
| Kim, NJ | 1 |
| Yoo, SE | 1 |
| Lee, BH | 1 |
| Seo, HW | 1 |
| Kim, SO | 1 |
| Lim, H | 1 |
| Clark, JE | 1 |
| Naughton, P | 1 |
| Shurey, S | 1 |
| Green, CJ | 1 |
| Johnson, TR | 1 |
| Mann, BE | 1 |
| Foresti, R | 1 |
| Motterlini, R | 1 |
| Zhu, HF | 1 |
| Dong, JW | 1 |
| Zhu, WZ | 1 |
| Ding, HL | 1 |
| Zhou, ZN | 1 |
| Oldenburg, O | 1 |
| Yang, XM | 1 |
| Krieg, T | 1 |
| Garlid, KD | 2 |
| Cohen, MV | 2 |
| Grover, GJ | 5 |
| Downey, JM | 2 |
| Jones, SP | 1 |
| Greer, JJ | 1 |
| Kakkar, AK | 1 |
| Ware, PD | 1 |
| Turnage, RH | 1 |
| Hicks, M | 1 |
| van Haperen, R | 1 |
| de Crom, R | 1 |
| Kawashima, S | 1 |
| Yokoyama, M | 1 |
| Lefer, DJ | 1 |
| Loubani, M | 1 |
| Hassouna, A | 1 |
| Galiñanes, M | 2 |
| Nayeem, MA | 2 |
| Piriou, V | 1 |
| Chiari, P | 1 |
| Gateau-Roesch, O | 1 |
| Argaud, L | 1 |
| Muntean, D | 1 |
| Salles, D | 1 |
| Loufouat, J | 1 |
| Gueugniaud, PY | 1 |
| Lehot, JJ | 1 |
| Ovize, M | 1 |
| Beresewicz, A | 1 |
| Maczewski, M | 1 |
| Duda, M | 1 |
| Diodato, MD | 1 |
| Shah, NR | 1 |
| Prasad, SM | 1 |
| Gaynor, SL | 1 |
| Lawton, JS | 1 |
| Damiano, RJ | 1 |
| Ritchie, RH | 1 |
| Gordon, JM | 1 |
| Woodman, OL | 1 |
| Cao, AH | 1 |
| Dusting, GJ | 1 |
| Shinmura, K | 1 |
| Tamaki, K | 2 |
| Bolli, R | 1 |
| Zhu, YH | 1 |
| Wang, X | 1 |
| Johansen, D | 1 |
| Ytrehus, K | 1 |
| Mühlfeld, C | 1 |
| Urru, M | 1 |
| Rümelin, R | 1 |
| Mirzaie, M | 1 |
| Schöndube, F | 1 |
| Richter, J | 1 |
| Dörge, H | 1 |
| Gok, S | 1 |
| Vatansever, S | 1 |
| Vural, K | 1 |
| Sekuri, C | 1 |
| Izanli, A | 1 |
| Tezcan, A | 1 |
| Cilaker, S | 1 |
| Sivarajah, A | 1 |
| McDonald, MC | 1 |
| Thiemermann, C | 4 |
| Brennan, JP | 1 |
| Southworth, R | 1 |
| Medina, RA | 1 |
| Davidson, SM | 1 |
| Duchen, MR | 1 |
| Shattock, MJ | 1 |
| Pasdois, P | 1 |
| Beauvoit, B | 1 |
| Tariosse, L | 1 |
| Vinassa, B | 1 |
| Bonoron-Adèle, S | 1 |
| Santos, PD | 1 |
| Gao, H | 1 |
| Chen, L | 1 |
| Yang, HT | 1 |
| McCullough, JR | 1 |
| D'Alonzo, AJ | 2 |
| Sargent, CA | 2 |
| Atwal, KS | 2 |
| Moritani, K | 2 |
| Miyazaki, T | 2 |
| Miyoshi, S | 2 |
| Asanagi, M | 1 |
| Zhao, LS | 1 |
| Mitamura, H | 1 |
| Ogawa, S | 2 |
| Yao, Z | 3 |
| Gross, GJ | 6 |
| Hide, EJ | 3 |
| Ney, P | 1 |
| Piper, J | 2 |
| Vane, JR | 1 |
| Wilde, MW | 1 |
| Dzwonczyk, S | 1 |
| Tuttle, JG | 1 |
| Murray, HN | 1 |
| Atwal, K | 1 |
| Schultz, JE | 1 |
| Qian, YZ | 2 |
| Kukreja, RC | 3 |
| Docherty, JC | 1 |
| Gunter, HE | 1 |
| Kuzio, B | 1 |
| Shoemaker, L | 1 |
| Yang, L | 1 |
| Deslauriers, R | 1 |
| Hoag, JB | 1 |
| D'Angelo, M | 1 |
| Sakamoto, K | 1 |
| Yamazaki, J | 1 |
| Nagao, T | 1 |
| Bethell, HW | 1 |
| Vandenberg, JI | 1 |
| Smith, GA | 1 |
| Grace, AA | 1 |
| Wolk, R | 1 |
| Cobbe, SM | 1 |
| Kane, KA | 1 |
| Hicks, MN | 1 |
| Liu, Y | 1 |
| Sato, T | 2 |
| Seharaseyon, J | 1 |
| Szewczyk, A | 1 |
| O'Rourke, B | 2 |
| Marbán, E | 2 |
| Ockaili, R | 1 |
| Emani, VR | 1 |
| Okubo, S | 1 |
| Brown, M | 1 |
| Krottapalli, K | 1 |
| Tong, J | 1 |
| Tan, X | 1 |
| Shao, Z | 1 |
| Kim, WC | 1 |
| vanden Hoek, TL | 1 |
| Becker, LB | 2 |
| Head, CA | 1 |
| Schumacker, PT | 2 |
| Vanden Hoek, T | 1 |
| Shao, ZH | 1 |
| Li, CQ | 1 |
| Ghosh, S | 1 |
| Standen, NB | 1 |
| Obata, T | 1 |
| Yamanaka, Y | 1 |
| Ito, K | 1 |
| Shigematsu, S | 1 |
| Abe, T | 1 |
| Li, Y | 1 |
| Arita, M | 1 |
| Minners, J | 1 |
| van den Bos, EJ | 1 |
| Schwalb, H | 1 |
| Opie, LH | 1 |
| Sack, MN | 1 |
| Fryer, RM | 1 |
| Hsu, AK | 1 |
| Nagase, H | 1 |
| Headrick, JP | 1 |
| Gauthier, NS | 1 |
| Morrison, R | 1 |
| Matherne, GP | 1 |
| Henry, MM | 1 |
| Baker, JE | 2 |
| Tani, M | 1 |
| Honma, Y | 1 |
| Hasegawa, H | 1 |
| Bajgar, R | 1 |
| Lodge, NJ | 1 |
| Sleph, PG | 1 |
| Darbenzio, RB | 1 |
| Hess, TA | 1 |
| Smith, MA | 1 |
| Paucek, P | 1 |
| Imahashi, K | 1 |
| Nishimura, T | 1 |
| Yoshioka, J | 1 |
| Kusuoka, H | 1 |
| Karanth, KS | 2 |
| Murata, M | 1 |
| Akao, M | 1 |
| Zhang, HY | 1 |
| McPherson, BC | 1 |
| Liu, H | 1 |
| Baman, TS | 1 |
| Rock, P | 1 |
| Tonkovic-Capin, M | 1 |
| Bosnjak, ZJ | 1 |
| Tweddell, JS | 1 |
| Fitzpatrick, CM | 1 |
| Feng, J | 1 |
| Rosenkranz, ER | 1 |
| Auchampach, JA | 1 |
1 review available for 5-hydroxydecanoate and Heart Disease, Ischemic
| Article | Year |
|---|---|
Mitochondrial ATP-dependent potassium channels. Viable candidate effectors of ischemic preconditioning.
Topics: Animals; Decanoic Acids; Diazoxide; Heart; Hydroxy Acids; Intracellular Membranes; Ischemic Precondi | 1999 |
73 other studies available for 5-hydroxydecanoate and Heart Disease, Ischemic
| Article | Year |
|---|---|
Exendin-4 attenuates ischemia-induced ventricular arrhythmias in rats.
Topics: Animals; Anti-Arrhythmia Agents; Blood Pressure; Decanoic Acids; Disease Models, Animal; Exenatide; | 2013 |
Sevoflurane postconditioning affects post-ischaemic myocardial mitochondrial ATP-sensitive potassium channel function and apoptosis in ageing rats.
Topics: Aging; Animals; Apoptosis; bcl-2-Associated X Protein; Coronary Circulation; Decanoic Acids; Hemodyn | 2016 |
Myocardial triggers involved in activation of remote ischaemic preconditioning.
Topics: Adenosine Triphosphate; Animals; Decanoic Acids; Heart; Hindlimb; Hydrogen Peroxide; Hydroxy Acids; | 2016 |
Delayed anti-arrhythmic effect of nitroglycerin in anesthetized rats: involvement of CGRP, PKC and mK ATP channels.
Topics: Anesthesia; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Benzophenanthridines; Calcitonin | 2009 |
Oral glyburide, but not glimepiride, blocks the infarct-size limiting effects of pioglitazone.
Topics: Administration, Oral; Animals; Body Weight; Coronary Vessels; Data Interpretation, Statistical; Deca | 2008 |
Sulforaphane protects ischemic injury of hearts through antioxidant pathway and mitochondrial K(ATP) channels.
Topics: Animals; Antioxidants; Atrial Natriuretic Factor; bcl-2-Associated X Protein; Caspase 3; Decanoic Ac | 2010 |
Polyphenol (-)-epigallocatechin gallate during ischemia limits infarct size via mitochondrial K(ATP) channel activation in isolated rat hearts.
Topics: Animals; Anti-Arrhythmia Agents; Antioxidants; Catechin; Decanoic Acids; Glyburide; Heart; Hemodynam | 2010 |
Antidiabetic drug voglibose is protective against ischemia-reperfusion injury through glucagon-like peptide 1 receptors and the phosphoinositide 3-kinase-Akt-endothelial nitric oxide synthase pathway in rabbits.
Topics: alpha-Glucosidases; Animals; Arginine; Decanoic Acids; Glucagon-Like Peptide 1; Glucagon-Like Peptid | 2010 |
Mitochondrial uncoupling agents trigger ventricular fibrillation in isolated rat hearts.
Topics: 2,4-Dinitrophenol; Adenosine Triphosphate; Animals; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cyclo | 2011 |
Inhibiting mitochondrial permeability transition pore opening: a new paradigm for myocardial preconditioning?
Topics: Adenosine; Analysis of Variance; Animals; Atractyloside; Calcineurin Inhibitors; Cyclosporine; Decan | 2002 |
Intestinal ischemia preconditions myocardium: role of protein kinase C and mitochondrial K(ATP) channel.
Topics: Alkaloids; Analysis of Variance; Animals; Benzophenanthridines; Blood Pressure; Decanoic Acids; Enzy | 2002 |
Infarct size limitation by nicorandil: roles of mitochondrial K(ATP) channels, sarcolemmal K(ATP) channels, and protein kinase C.
Topics: Animals; Benzamides; Decanoic Acids; Enzyme Inhibitors; Glycine; Hemodynamics; Hydroxy Acids; In Vit | 2002 |
Anesthetic preconditioning attenuates mitochondrial Ca2+ overload during ischemia in Guinea pig intact hearts: reversal by 5-hydroxydecanoic acid.
Topics: Anesthetics; Animals; Calcium; Decanoic Acids; Guinea Pigs; Heart Rate; Hydroxy Acids; Ischemic Prec | 2002 |
The effects of ischaemic preconditioning, diazoxide and 5-hydroxydecanoate on rat heart mitochondrial volume and respiration.
Topics: Acyl Coenzyme A; Animals; Decanoic Acids; Diazoxide; Heart; Hydroxy Acids; Ischemic Preconditioning, | 2002 |
Preconditioning with sevoflurane reduces changes in nicotinamide adenine dinucleotide during ischemia-reperfusion in isolated hearts: reversal by 5-hydroxydecanoic acid.
Topics: Anesthetics, Inhalation; Animals; ATP-Binding Cassette Transporters; Blood Pressure; Coronary Circul | 2003 |
Effective protection by NHE-1 inhibition in ischemic and reperfused heart under preconditioning blockade.
Topics: Animals; Anti-Arrhythmia Agents; Decanoic Acids; Diastole; Guanidines; Heart; Hydroxy Acids; In Vitr | 2003 |
Selective mitochondrial KATP channel activation by nicorandil and 3-pyridyl pinacidil results in antiarrhythmic effect in an anesthetized rabbit model of myocardial ischemia/reperfusion.
Topics: Animals; Anti-Arrhythmia Agents; Antioxidants; Arrhythmias, Cardiac; Blood Pressure; Decanoic Acids; | 2003 |
Cardioselective anti-ischemic ATP-sensitive potassium channel (KATP) openers: benzopyranyl indoline and indole analogues.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cardiotonic Agents; Crystallography, X-Ray; Decanoic A | 2003 |
Cardioprotective actions by a water-soluble carbon monoxide-releasing molecule.
Topics: Animals; Carbon Monoxide; Cardiotonic Agents; Cells, Cultured; Decanoic Acids; Disease Models, Anima | 2003 |
ATP-dependent potassium channels involved in the cardiac protection induced by intermittent hypoxia against ischemia/reperfusion injury.
Topics: Animals; Calcium; Decanoic Acids; Glyburide; Heart Ventricles; Hemodynamics; Hydroxy Acids; Hypoxia; | 2003 |
P1075 opens mitochondrial K(ATP) channels and generates reactive oxygen species resulting in cardioprotection of rabbit hearts.
Topics: Animals; Brain Chemistry; Decanoic Acids; Diazoxide; Glyburide; Guanidines; Hydroxy Acids; Ischemic | 2003 |
Endothelial nitric oxide synthase overexpression attenuates myocardial reperfusion injury.
Topics: Alkenes; Animals; Cattle; Decanoic Acids; Echocardiography; Heart; Hemodynamics; Humans; Hydroxy Aci | 2004 |
Delayed preconditioning of the human myocardium: signal transduction and clinical implications.
Topics: Acetylcholine; Aged; Alkaloids; Anisomycin; Antihypertensive Agents; Benzophenanthridines; Culture T | 2004 |
Sublethal simulated ischemia promotes delayed resistance against ischemia via ATP-sensitive (K+) channels in murine myocytes: role of PKC and iNOS.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Cells, Cultured; Decanoic Acids; Enzyme Act | 2004 |
Desflurane-induced preconditioning alters calcium-induced mitochondrial permeability transition.
Topics: Anesthetics, Inhalation; Animals; Calcium; Cyclosporine; Decanoic Acids; Desflurane; Hemodynamics; H | 2004 |
Effect of classic preconditioning and diazoxide on endothelial function and O2- and NO generation in the post-ischemic guinea-pig heart.
Topics: Animals; Benzamides; Decanoic Acids; Diazoxide; Dose-Response Relationship, Drug; Endothelium, Vascu | 2004 |
Donor heart preservation with pinacidil: the role of the mitochondrial K ATP channel.
Topics: Adenosine; Allopurinol; Animals; Benzamides; Cardiotonic Agents; Coronary Circulation; Decanoic Acid | 2004 |
Annexin-1 peptide Anx-1(2-26) protects adult rat cardiac myocytes from cellular injury induced by simulated ischaemia.
Topics: Alkaloids; Analysis of Variance; Animals; Annexin A1; Benzophenanthridines; Cells, Cultured; Creatin | 2005 |
Short-term caloric restriction improves ischemic tolerance independent of opening of ATP-sensitive K+ channels in both young and aged hearts.
Topics: Adenosine Triphosphate; Aging; AMP-Activated Protein Kinases; Animals; Body Weight; Caloric Restrict | 2005 |
Overexpression of heat-shock protein 20 in rat heart myogenic cells confers protection against simulated ischemia/reperfusion injury.
Topics: Adenoviridae; Animals; Apoptosis; Caspase 3; Caspases; Cells, Cultured; Decanoic Acids; HSP20 Heat-S | 2005 |
Exogenous hydrogen sulfide (H2S) protects against regional myocardial ischemia-reperfusion injury--Evidence for a role of K ATP channels.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Cardiac Output; Decanoic Acids; Glyburide; | 2006 |
Myocardial ischemia tolerance in the newborn rat involving opioid receptors and mitochondrial K+ channels.
Topics: Animals; Decanoic Acids; Glucose; Hydroxy Acids; Mannitol; Mitochondria; Myocardial Ischemia; Myocyt | 2006 |
The role of ATP sensitive K+ channels and of nitric oxide synthase on myocardial ischemia/reperfusion-induced apoptosis.
Topics: Animals; Apoptosis; Benzamides; Decanoic Acids; Hydroxy Acids; Immunoenzyme Techniques; In Situ Nick | 2006 |
The production of hydrogen sulfide limits myocardial ischemia and reperfusion injury and contributes to the cardioprotective effects of preconditioning with endotoxin, but not ischemia in the rat.
Topics: Alkynes; Animals; Cardiotonic Agents; Cystathionine gamma-Lyase; Decanoic Acids; Endotoxins; Enzyme | 2006 |
Mitochondrial uncoupling, with low concentration FCCP, induces ROS-dependent cardioprotection independent of KATP channel activation.
Topics: Acetylcysteine; Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Carbonyl Cyanide p-Trifluor | 2006 |
MitoK(ATP)-dependent changes in mitochondrial volume and in complex II activity during ischemic and pharmacological preconditioning of Langendorff-perfused rat heart.
Topics: Adenosine Diphosphate; Animals; Antihypertensive Agents; Cell Respiration; Decanoic Acids; Diazoxide | 2006 |
Activation of alpha1B-adrenoceptors alleviates ischemia/reperfusion injury by limitation of mitochondrial Ca2+ overload in cardiomyocytes.
Topics: Adenosine Triphosphate; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Anima | 2007 |
Cardioprotective profile of the cardiac-selective ATP-sensitive potassium channel opener BMS-180448.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Aorta; Benzopyrans; Cromakalim; Decanoic Ac | 1995 |
Blockade of ATP-sensitive potassium channels by 5-hydroxydecanoate suppresses monophasic action potential shortening during regional myocardial ischemia.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bl | 1994 |
A comparison of adenosine-induced cardioprotection and ischemic preconditioning in dogs. Efficacy, time course, and role of KATP channels.
Topics: Adenosine; Adenosine Triphosphate; Animals; Decanoic Acids; Dogs; Female; Glyburide; Hydroxy Acids; | 1994 |
Reduction by prostaglandin E1 or prostaglandin E0 of myocardial infarct size in the rabbit by activation of ATP-sensitive potassium channels.
Topics: Adenosine Triphosphate; Alprostadil; Animals; Anti-Arrhythmia Agents; Biotransformation; Blood Press | 1995 |
Endothelin-1-induced reduction of myocardial infarct size by activation of ATP-sensitive potassium channels in a rabbit model of myocardial ischaemia and reperfusion.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Arterial Occlusive Diseases; Blood Pressure | 1995 |
Glyburide-reversible cardioprotective effects of calcium-independent phospholipase A2 inhibition in ischemic rat hearts.
Topics: Animals; Anti-Arrhythmia Agents; Calcium; Coronary Circulation; Decanoic Acids; Dose-Response Relati | 1996 |
Limitation of myocardial infarct size in the rabbit by ischaemic preconditioning is abolished by sodium 5-hydroxydecanoate.
Topics: Animals; Decanoic Acids; Hydroxy Acids; Myocardial Infarction; Myocardial Ischemia; Myocardial Reper | 1996 |
Different responses of epicardium and endocardium to KATP channel modulators during regional ischemia.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Decanoic Acids; Dogs; Endocardium; Hydroxy Acids | 1996 |
The ischemia-selective KATP channel antagonist, 5-hydroxydecanoate, blocks ischemic preconditioning in the rat heart.
Topics: Adenosine Triphosphate; Animals; Decanoic Acids; Hemodynamics; Hydroxy Acids; Ischemic Preconditioni | 1997 |
Effects of cromakalim and glibenclamide on myocardial high energy phosphates and intracellular pH during ischemia-reperfusion: 31P NMR studies.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Benzopyrans; Coronary Circulation; Cromakal | 1997 |
ATP-sensitive potassium channel mediates delayed ischemic protection by heat stress in rabbit heart.
Topics: Animals; Anti-Arrhythmia Agents; Blood Pressure; Decanoic Acids; Glyburide; Heart Rate; Heat Stress | 1997 |
5-hydroxydecanoate selectively reduces the initial increase in extracellular K+ in ischemic guinea-pig heart.
Topics: Animals; Cardiovascular Agents; Decanoic Acids; Guinea Pigs; Heart; Hydroxy Acids; In Vitro Techniqu | 1998 |
Changes in ventricular repolarization during acidosis and low-flow ischemia.
Topics: Acidosis; Action Potentials; Adenosine Triphosphate; Animals; Decanoic Acids; Ferrets; Glyburide; He | 1998 |
Relevance of inter- and intraventricular electrical dispersion to arrhythmogenesis in normal and ischaemic rabbit myocardium: a study with cromakalim, 5-hydroxydecanoate and glibenclamide.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Coronary Disease; Cromakal | 1999 |
Opening of mitochondrial KATP channel induces early and delayed cardioprotective effect: role of nitric oxide.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Coronary Vessels; Decanoic Acids; Diazoxide | 1999 |
Role of reactive oxygen species in acetylcholine-induced preconditioning in cardiomyocytes.
Topics: Acetylcholine; Animals; Anti-Arrhythmia Agents; Cardiotonic Agents; Cells, Cultured; Chick Embryo; D | 1999 |
Preconditioning in cardiomyocytes protects by attenuating oxidant stress at reperfusion.
Topics: Animals; Anti-Arrhythmia Agents; Cell Death; Cells, Cultured; Chick Embryo; Decanoic Acids; Hydrogen | 2000 |
Evidence for mitochondrial K ATP channels as effectors of human myocardial preconditioning.
Topics: Analysis of Variance; Cell Membrane; Decanoic Acids; Diazoxide; Dose-Response Relationship, Drug; Gl | 2000 |
Block of cardiac ATP-sensitive K(+) channels reduces hydroxyl radicals in the rat myocardium.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; Cromakalim; Decano | 2000 |
JTV-519, a novel cardioprotective agent, improves the contractile recovery after ischaemia-reperfusion in coronary perfused guinea-pig ventricular muscles.
Topics: Action Potentials; Adenosine Triphosphate; Alkaloids; Animals; Benzophenanthridines; Calcium Channel | 2000 |
Dinitrophenol, cyclosporin A, and trimetazidine modulate preconditioning in the isolated rat heart: support for a mitochondrial role in cardioprotection.
Topics: Animals; Anti-Arrhythmia Agents; Cyclosporine; Decanoic Acids; Dinitrophenols; Enzyme Inhibitors; Ho | 2000 |
Opioid-induced cardioprotection against myocardial infarction and arrhythmias: mitochondrial versus sarcolemmal ATP-sensitive potassium channels.
Topics: Adenosine Triphosphate; Analgesics, Opioid; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; B | 2000 |
Cardioprotection by K(ATP) channels in wild-type hearts and hearts overexpressing A(1)-adenosine receptors.
Topics: Adenosine Triphosphate; Animals; Decanoic Acids; Heart; Hydroxy Acids; In Vitro Techniques; Mice; Mi | 2000 |
Increased mitochondrial K(ATP) channel activity during chronic myocardial hypoxia: is cardioprotection mediated by improved bioenergetics?
Topics: Adaptation, Physiological; Adenosine Triphosphate; Animals; Animals, Newborn; Benzopyrans; Cell Hypo | 2000 |
Direct activation of mitochondrial K(ATP) channels mimics preconditioning but protein kinase C activation is less effective in middle-aged rat hearts.
Topics: Aging; Animals; Anti-Arrhythmia Agents; Creatine Kinase; Decanoic Acids; Diglycerides; Heart; Hydrox | 2001 |
Mitochondrial K(ATP)channel opening during index ischemia and following myocardial reperfusion in ischemic rat hearts.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Decanoic Acids; Heart; Hydroxy Acids; Ion C | 2001 |
Pharmacologic characterization of BMS-191095, a mitochondrial K(ATP) opener with no peripheral vasodilator or cardiac action potential shortening activity.
Topics: Action Potentials; Animals; Benzopyrans; Cardiovascular Agents; Cromakalim; Decanoic Acids; Dose-Res | 2001 |
Role of intracellular Na(+) kinetics in preconditioned rat heart.
Topics: Animals; Decanoic Acids; Diazoxide; Hydroxy Acids; In Vitro Techniques; Intracellular Fluid; Ischemi | 2001 |
Effects of administration of nicorandil or bimakalim prior to and during ischemia or reperfusion on survival rate, ischemia/reperfusion-induced arrhythmias and infarct size in anesthetized rabbits.
Topics: Animals; Antihypertensive Agents; Arrhythmias, Cardiac; Benzopyrans; Blood Gas Analysis; Coronary Di | 2001 |
Mitochondrial ATP-sensitive potassium channels attenuate matrix Ca(2+) overload during simulated ischemia and reperfusion: possible mechanism of cardioprotection.
Topics: Bongkrekic Acid; Calcium; Cell Separation; Cytoprotection; Decanoic Acids; Diazoxide; Dose-Response | 2001 |
Selective mitochondrial K(ATP) channel activation results in antiarrhythmic effect during experimental myocardial ischemia/reperfusion in anesthetized rabbits.
Topics: Anesthesia; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Blood Gas Analysis; Blood Pressur | 2002 |
H(2)O(2) opens mitochondrial K(ATP) channels and inhibits GABA receptors via protein kinase C-epsilon in cardiomyocytes.
Topics: Animals; Calcium Channel Blockers; Chick Embryo; Decanoic Acids; Enzyme Inhibitors; Fluoresceins; Fl | 2002 |
Delayed cardioprotection by isoflurane: role of K(ATP) channels.
Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Benzamides; Cytoprotection; Decanoic Acids; Dose- | 2002 |
Opening of mitochondrial K(ATP) channel occurs downstream of PKC-epsilon activation in the mechanism of preconditioning.
Topics: Adenosine Triphosphate; Animals; Decanoic Acids; Diazoxide; Enzyme Activation; Hemodynamics; Hydroxy | 2002 |
Diazoxide protects the rabbit heart following cardioplegic ischemia.
Topics: Animals; Anti-Arrhythmia Agents; Cardioplegic Solutions; Coronary Circulation; Decanoic Acids; Diast | 2002 |
Blockade of ischaemic preconditioning in dogs by the novel ATP dependent potassium channel antagonist sodium 5-hydroxydecanoate.
Topics: Animals; Benzopyrans; Blood Glucose; Blood Pressure; Coronary Circulation; Coronary Vessels; Decanoi | 1992 |