5-hydroxydecanoate has been researched along with Coronary Disease in 9 studies
5-hydroxydecanoic acid: Potassium Channel Blocker; RN refers to parent cpd
Coronary Disease: An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We investigated the effects of administration of non-hypotensive doses of ATP-sensitive K+ channel (KATP) openers (nicorandil and bimakalim), and a specific mitochondrial KATP channel blocker (5-hydroxydecanoate) prior to and during coronary occlusion as well as prior to and during post-ischemic reperfusion on survival rate, ischemia-induced and reperfusion-induced arrhythmias and myocardial infarct size in anesthetized albino rabbits." | 7.71 | Effects of administration of nicorandil or bimakalim prior to and during ischemia or reperfusion on survival rate, ischemia/reperfusion-induced arrhythmias and infarct size in anesthetized rabbits. ( Das, B; Karanth, KS; Sarkar, C, 2001) |
| "We investigated the effects of sodium 5-hydroxydecanoate (5-HD) on experimentally induced ischemic arrhythmia and its mechanisms of action by biochemical and electrophysiological techniques." | 7.67 | [Study of mechanism and effect of sodium 5-hydroxydecanoate on experimental ischemic ventricular arrhythmia]. ( Dabasaki, T; Funato, H; Ishikawa, H; Kayamoto, M; Niho, T; Notsu, T; Takahashi, H; Tanaka, I; Yamasaki, F; Yamazaki, M, 1987) |
| "We investigated the effects of administration of non-hypotensive doses of ATP-sensitive K+ channel (KATP) openers (nicorandil and bimakalim), and a specific mitochondrial KATP channel blocker (5-hydroxydecanoate) prior to and during coronary occlusion as well as prior to and during post-ischemic reperfusion on survival rate, ischemia-induced and reperfusion-induced arrhythmias and myocardial infarct size in anesthetized albino rabbits." | 3.71 | Effects of administration of nicorandil or bimakalim prior to and during ischemia or reperfusion on survival rate, ischemia/reperfusion-induced arrhythmias and infarct size in anesthetized rabbits. ( Das, B; Karanth, KS; Sarkar, C, 2001) |
| "We investigated the effects of sodium 5-hydroxydecanoate (5-HD) on experimentally induced ischemic arrhythmia and its mechanisms of action by biochemical and electrophysiological techniques." | 3.67 | [Study of mechanism and effect of sodium 5-hydroxydecanoate on experimental ischemic ventricular arrhythmia]. ( Dabasaki, T; Funato, H; Ishikawa, H; Kayamoto, M; Niho, T; Notsu, T; Takahashi, H; Tanaka, I; Yamasaki, F; Yamazaki, M, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (11.11) | 18.7374 |
| 1990's | 6 (66.67) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 1 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Aiello, EA | 1 |
| Cingolani, HE | 1 |
| Yao, Z | 1 |
| Gross, GJ | 1 |
| Hide, EJ | 1 |
| Piper, J | 1 |
| Thiemermann, C | 1 |
| Wolk, R | 1 |
| Cobbe, SM | 1 |
| Kane, KA | 1 |
| Hicks, MN | 1 |
| Das, B | 1 |
| Sarkar, C | 1 |
| Karanth, KS | 1 |
| Grover, GJ | 3 |
| Sleph, PG | 3 |
| Dzwonczyk, S | 3 |
| McCullough, JR | 1 |
| Normandin, DE | 1 |
| Conder, ML | 1 |
| Niho, T | 1 |
| Notsu, T | 1 |
| Ishikawa, H | 1 |
| Funato, H | 1 |
| Yamazaki, M | 1 |
| Takahashi, H | 1 |
| Tanaka, I | 1 |
| Kayamoto, M | 1 |
| Dabasaki, T | 1 |
| Yamasaki, F | 1 |
9 other studies available for 5-hydroxydecanoate and Coronary Disease
| Article | Year |
|---|---|
A possible subcellular mechanism underlying the "French paradox": the opening of mitochondrial K(ATP) channels.
Topics: Animals; Cells, Cultured; Coronary Disease; Decanoic Acids; Flavoproteins; Guinea Pigs; Hydroxy Acid | 2011 |
The ATP-dependent potassium channel: an endogenous cardioprotective mechanism.
Topics: Acetylcholine; Adenosine; Animals; Anti-Arrhythmia Agents; Coronary Disease; Decanoic Acids; Disease | 1994 |
Endothelin-1-induced reduction of myocardial infarct size by activation of ATP-sensitive potassium channels in a rabbit model of myocardial ischaemia and reperfusion.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Arterial Occlusive Diseases; Blood Pressure | 1995 |
Relevance of inter- and intraventricular electrical dispersion to arrhythmogenesis in normal and ischaemic rabbit myocardium: a study with cromakalim, 5-hydroxydecanoate and glibenclamide.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Coronary Disease; Cromakal | 1999 |
Effects of administration of nicorandil or bimakalim prior to and during ischemia or reperfusion on survival rate, ischemia/reperfusion-induced arrhythmias and infarct size in anesthetized rabbits.
Topics: Animals; Antihypertensive Agents; Arrhythmias, Cardiac; Benzopyrans; Blood Gas Analysis; Coronary Di | 2001 |
Pharmacologic profile of cromakalim in the treatment of myocardial ischemia in isolated rat hearts and anesthetized dogs.
Topics: Anesthesia; Animals; Anti-Arrhythmia Agents; Benzopyrans; Blood Pressure; Cardiovascular Agents; Cor | 1990 |
Specific block of the anti-ischemic actions of cromakalim by sodium 5-hydroxydecanoate.
Topics: Animals; Benzopyrans; Coronary Disease; Cromakalim; Decanoic Acids; Electrophysiology; Glyburide; He | 1991 |
Reduction of ischemic damage in isolated rat hearts by the potassium channel opener, RP 52891.
Topics: Adenosine Triphosphate; Animals; Coronary Disease; Decanoic Acids; Glyburide; Heart; Hydroxy Acids; | 1990 |
[Study of mechanism and effect of sodium 5-hydroxydecanoate on experimental ischemic ventricular arrhythmia].
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Coronary Disease; Decanoic Acids; Dogs; Energ | 1987 |