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5-hydroxydecanoate and Brain Ischemia

5-hydroxydecanoate has been researched along with Brain Ischemia in 8 studies

5-hydroxydecanoic acid: Potassium Channel Blocker; RN refers to parent cpd

Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.

Research Excerpts

ExcerptRelevanceReference
" We tested whether Diaz preserves endothelium-dependent (hypercapnia) or -independent [iloprost (Ilo)] cerebrovascular dilator responses after ischemia-reperfusion (I/R) in newborn pigs and whether the effect of Diaz is sensitive to 5-hydroxydecanoate (5-HD), an inhibitor of mitoKATP channels."7.73Diazoxide preserves hypercapnia-induced arteriolar vasodilation after global cerebral ischemia in piglets. ( Bari, F; Busija, DW; Domoki, F; Farkas, E; Kis, B; Nagy, K, 2005)
"Obesity is associated with increased infarct volumes and adverse outcomes following ischemic stroke."5.40Sevoflurane postconditioning against cerebral ischemic neuronal injury is abolished in diet-induced obesity: role of brain mitochondrial KATP channels. ( Chen, Y; Fang, X; Jiang, Y; Xu, J; Yang, Z; Zhang, Y, 2014)
"The number of FJ-positive degenerating neurons in the CA1 area of the hippocampus, the cerebellum and the thalamic reticular nucleus of the ketogenic diet-fed rats with or without glibenclamide or 5-hydroxydecanoate pre-treatment before cardiac arrest-induced cerebral ischemia is zero."3.75Intracisternal administration of glibenclamide or 5-hydroxydecanoate does not reverse the neuroprotective effect of ketogenic diet against ischemic brain injury-induced neurodegeneration. ( Pham, L; Tai, KK; Truong, DD, 2009)
" We tested whether Diaz preserves endothelium-dependent (hypercapnia) or -independent [iloprost (Ilo)] cerebrovascular dilator responses after ischemia-reperfusion (I/R) in newborn pigs and whether the effect of Diaz is sensitive to 5-hydroxydecanoate (5-HD), an inhibitor of mitoKATP channels."3.73Diazoxide preserves hypercapnia-induced arteriolar vasodilation after global cerebral ischemia in piglets. ( Bari, F; Busija, DW; Domoki, F; Farkas, E; Kis, B; Nagy, K, 2005)
"Obesity is associated with increased infarct volumes and adverse outcomes following ischemic stroke."1.40Sevoflurane postconditioning against cerebral ischemic neuronal injury is abolished in diet-induced obesity: role of brain mitochondrial KATP channels. ( Chen, Y; Fang, X; Jiang, Y; Xu, J; Yang, Z; Zhang, Y, 2014)
"Pretreatment with diazoxide protected both Sur1KO and wild-type neurons, while 5-hydroxydecanoate augmented neurodegeneration in both strains of animals when administered before a 20-minute bout of ischemia."1.32Ischemic preconditioning in the hippocampus of a knockout mouse lacking SUR1-based K(ATP) channels. ( Aguilar-Bryan, L; Barrios, R; Bryan, J; Goodman, JC; Muñoz, A; Nakazaki, M; Onetti, CG, 2003)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (12.50)18.2507
2000's5 (62.50)29.6817
2010's2 (25.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Yang, Z1
Chen, Y1
Zhang, Y1
Jiang, Y1
Fang, X1
Xu, J1
Watanabe, M1
Katsura, K1
Ohsawa, I1
Mizukoshi, G1
Takahashi, K1
Asoh, S1
Ohta, S1
Katayama, Y1
Tai, KK1
Pham, L1
Truong, DD1
Robin, E1
Simerabet, M1
Hassoun, SM1
Adamczyk, S1
Tavernier, B1
Vallet, B1
Bordet, R1
Lebuffe, G1
Muñoz, A1
Nakazaki, M1
Goodman, JC1
Barrios, R1
Onetti, CG1
Bryan, J1
Aguilar-Bryan, L1
Liu, D1
Slevin, JR1
Lu, C1
Chan, SL1
Hansson, M1
Elmér, E1
Mattson, MP1
Domoki, F2
Kis, B1
Nagy, K1
Farkas, E1
Busija, DW2
Bari, F2
Perciaccante, JV1
Veltkamp, R1

Other Studies

8 other studies available for 5-hydroxydecanoate and Brain Ischemia

ArticleYear
Sevoflurane postconditioning against cerebral ischemic neuronal injury is abolished in diet-induced obesity: role of brain mitochondrial KATP channels.
    Molecular medicine reports, 2014, Volume: 9, Issue:3

    Topics: Animals; Body Weight; Brain; Brain Injuries; Brain Ischemia; Decanoic Acids; Diazoxide; Diet, High-F

2014
Involvement of mitoKATP channel in protective mechanisms of cerebral ischemic tolerance.
    Brain research, 2008, Oct-31, Volume: 1238

    Topics: Animals; Anti-Arrhythmia Agents; Brain Ischemia; Cells, Cultured; Decanoic Acids; Diazoxide; Gerbill

2008
Intracisternal administration of glibenclamide or 5-hydroxydecanoate does not reverse the neuroprotective effect of ketogenic diet against ischemic brain injury-induced neurodegeneration.
    Brain injury, 2009, Volume: 23, Issue:13-14

    Topics: Animals; Brain Ischemia; Decanoic Acids; Diet, Ketogenic; Fluoresceins; Glyburide; Heart Arrest; Hyd

2009
Postconditioning in focal cerebral ischemia: role of the mitochondrial ATP-dependent potassium channel.
    Brain research, 2011, Feb-23, Volume: 1375

    Topics: Animals; Behavior, Animal; Brain Ischemia; Calcium; Decanoic Acids; Hydroxy Acids; Infarction, Middl

2011
Ischemic preconditioning in the hippocampus of a knockout mouse lacking SUR1-based K(ATP) channels.
    Stroke, 2003, Volume: 34, Issue:1

    Topics: Adenosine Triphosphate; Animals; Brain Ischemia; Cell Survival; Decanoic Acids; Diazoxide; Hippocamp

2003
Involvement of mitochondrial K+ release and cellular efflux in ischemic and apoptotic neuronal death.
    Journal of neurochemistry, 2003, Volume: 86, Issue:4

    Topics: Animals; Apoptosis; Brain Ischemia; Cell Death; Cell Hypoxia; Cells, Cultured; Cyanides; Decanoic Ac

2003
Diazoxide preserves hypercapnia-induced arteriolar vasodilation after global cerebral ischemia in piglets.
    American journal of physiology. Heart and circulatory physiology, 2005, Volume: 289, Issue:1

    Topics: Animals; Animals, Newborn; Arterioles; Blood Pressure; Brain Ischemia; Cells, Cultured; Cerebrovascu

2005
Mitochondrial potassium channel opener diazoxide preserves neuronal-vascular function after cerebral ischemia in newborn pigs.
    Stroke, 1999, Volume: 30, Issue:12

    Topics: Animals; Animals, Newborn; Arterioles; Brain Ischemia; Decanoic Acids; Diazoxide; Dose-Response Rela

1999