5-hydroxydecanoate has been researched along with Brain Ischemia in 8 studies
5-hydroxydecanoic acid: Potassium Channel Blocker; RN refers to parent cpd
Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We tested whether Diaz preserves endothelium-dependent (hypercapnia) or -independent [iloprost (Ilo)] cerebrovascular dilator responses after ischemia-reperfusion (I/R) in newborn pigs and whether the effect of Diaz is sensitive to 5-hydroxydecanoate (5-HD), an inhibitor of mitoKATP channels." | 7.73 | Diazoxide preserves hypercapnia-induced arteriolar vasodilation after global cerebral ischemia in piglets. ( Bari, F; Busija, DW; Domoki, F; Farkas, E; Kis, B; Nagy, K, 2005) |
| "Obesity is associated with increased infarct volumes and adverse outcomes following ischemic stroke." | 5.40 | Sevoflurane postconditioning against cerebral ischemic neuronal injury is abolished in diet-induced obesity: role of brain mitochondrial KATP channels. ( Chen, Y; Fang, X; Jiang, Y; Xu, J; Yang, Z; Zhang, Y, 2014) |
| "The number of FJ-positive degenerating neurons in the CA1 area of the hippocampus, the cerebellum and the thalamic reticular nucleus of the ketogenic diet-fed rats with or without glibenclamide or 5-hydroxydecanoate pre-treatment before cardiac arrest-induced cerebral ischemia is zero." | 3.75 | Intracisternal administration of glibenclamide or 5-hydroxydecanoate does not reverse the neuroprotective effect of ketogenic diet against ischemic brain injury-induced neurodegeneration. ( Pham, L; Tai, KK; Truong, DD, 2009) |
| " We tested whether Diaz preserves endothelium-dependent (hypercapnia) or -independent [iloprost (Ilo)] cerebrovascular dilator responses after ischemia-reperfusion (I/R) in newborn pigs and whether the effect of Diaz is sensitive to 5-hydroxydecanoate (5-HD), an inhibitor of mitoKATP channels." | 3.73 | Diazoxide preserves hypercapnia-induced arteriolar vasodilation after global cerebral ischemia in piglets. ( Bari, F; Busija, DW; Domoki, F; Farkas, E; Kis, B; Nagy, K, 2005) |
| "Obesity is associated with increased infarct volumes and adverse outcomes following ischemic stroke." | 1.40 | Sevoflurane postconditioning against cerebral ischemic neuronal injury is abolished in diet-induced obesity: role of brain mitochondrial KATP channels. ( Chen, Y; Fang, X; Jiang, Y; Xu, J; Yang, Z; Zhang, Y, 2014) |
| "Pretreatment with diazoxide protected both Sur1KO and wild-type neurons, while 5-hydroxydecanoate augmented neurodegeneration in both strains of animals when administered before a 20-minute bout of ischemia." | 1.32 | Ischemic preconditioning in the hippocampus of a knockout mouse lacking SUR1-based K(ATP) channels. ( Aguilar-Bryan, L; Barrios, R; Bryan, J; Goodman, JC; Muñoz, A; Nakazaki, M; Onetti, CG, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 5 (62.50) | 29.6817 |
| 2010's | 2 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yang, Z | 1 |
| Chen, Y | 1 |
| Zhang, Y | 1 |
| Jiang, Y | 1 |
| Fang, X | 1 |
| Xu, J | 1 |
| Watanabe, M | 1 |
| Katsura, K | 1 |
| Ohsawa, I | 1 |
| Mizukoshi, G | 1 |
| Takahashi, K | 1 |
| Asoh, S | 1 |
| Ohta, S | 1 |
| Katayama, Y | 1 |
| Tai, KK | 1 |
| Pham, L | 1 |
| Truong, DD | 1 |
| Robin, E | 1 |
| Simerabet, M | 1 |
| Hassoun, SM | 1 |
| Adamczyk, S | 1 |
| Tavernier, B | 1 |
| Vallet, B | 1 |
| Bordet, R | 1 |
| Lebuffe, G | 1 |
| Muñoz, A | 1 |
| Nakazaki, M | 1 |
| Goodman, JC | 1 |
| Barrios, R | 1 |
| Onetti, CG | 1 |
| Bryan, J | 1 |
| Aguilar-Bryan, L | 1 |
| Liu, D | 1 |
| Slevin, JR | 1 |
| Lu, C | 1 |
| Chan, SL | 1 |
| Hansson, M | 1 |
| Elmér, E | 1 |
| Mattson, MP | 1 |
| Domoki, F | 2 |
| Kis, B | 1 |
| Nagy, K | 1 |
| Farkas, E | 1 |
| Busija, DW | 2 |
| Bari, F | 2 |
| Perciaccante, JV | 1 |
| Veltkamp, R | 1 |
8 other studies available for 5-hydroxydecanoate and Brain Ischemia
| Article | Year |
|---|---|
Sevoflurane postconditioning against cerebral ischemic neuronal injury is abolished in diet-induced obesity: role of brain mitochondrial KATP channels.
Topics: Animals; Body Weight; Brain; Brain Injuries; Brain Ischemia; Decanoic Acids; Diazoxide; Diet, High-F | 2014 |
Involvement of mitoKATP channel in protective mechanisms of cerebral ischemic tolerance.
Topics: Animals; Anti-Arrhythmia Agents; Brain Ischemia; Cells, Cultured; Decanoic Acids; Diazoxide; Gerbill | 2008 |
Intracisternal administration of glibenclamide or 5-hydroxydecanoate does not reverse the neuroprotective effect of ketogenic diet against ischemic brain injury-induced neurodegeneration.
Topics: Animals; Brain Ischemia; Decanoic Acids; Diet, Ketogenic; Fluoresceins; Glyburide; Heart Arrest; Hyd | 2009 |
Postconditioning in focal cerebral ischemia: role of the mitochondrial ATP-dependent potassium channel.
Topics: Animals; Behavior, Animal; Brain Ischemia; Calcium; Decanoic Acids; Hydroxy Acids; Infarction, Middl | 2011 |
Ischemic preconditioning in the hippocampus of a knockout mouse lacking SUR1-based K(ATP) channels.
Topics: Adenosine Triphosphate; Animals; Brain Ischemia; Cell Survival; Decanoic Acids; Diazoxide; Hippocamp | 2003 |
Involvement of mitochondrial K+ release and cellular efflux in ischemic and apoptotic neuronal death.
Topics: Animals; Apoptosis; Brain Ischemia; Cell Death; Cell Hypoxia; Cells, Cultured; Cyanides; Decanoic Ac | 2003 |
Diazoxide preserves hypercapnia-induced arteriolar vasodilation after global cerebral ischemia in piglets.
Topics: Animals; Animals, Newborn; Arterioles; Blood Pressure; Brain Ischemia; Cells, Cultured; Cerebrovascu | 2005 |
Mitochondrial potassium channel opener diazoxide preserves neuronal-vascular function after cerebral ischemia in newborn pigs.
Topics: Animals; Animals, Newborn; Arterioles; Brain Ischemia; Decanoic Acids; Diazoxide; Dose-Response Rela | 1999 |