5-hydroxydecanoate has been researched along with Arrhythmias, Cardiac in 23 studies
5-hydroxydecanoic acid: Potassium Channel Blocker; RN refers to parent cpd
Arrhythmias, Cardiac: Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by the abnormalities in HEART RATE, disorders of electrical impulse generation, or impulse conduction.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Previous clinical studies have shown that anisodamine could improve no-reflow phenomenon and prevent reperfusion arrhythmias, but whether this protective effect is related to the antagonism of the M-type cholinergic receptor or other potential mechanisms is uncertain." | 8.02 | Cardioprotective effect of anisodamine against ischemia/reperfusion injury through the mitochondrial ATP-sensitive potassium channel. ( Bai, S; Chen, T; Du, R; Er, L; Li, X; Wang, X; Wu, H; Zhang, L, 2021) |
| " In the present study, we investigated the effects of the administration of non-hypotensive doses of ATP-sensitive K+ channel (KATP) openers (nicorandil and 3-pyridyl pinacidil), a specific mitochondrial KATP channel blocker (5-hydroxydecanoate) and a specific sarcolemmal KATP channel blocker (HMR 1883; 1-[5-[2-(5-chloro-o-anisamido)ethyl]-2-methoxyphenyl]sulfonyl-3- methylthiourea) prior to and during coronary occlusion, as well as prior to and during post-ischemic reperfusion, on survival rate, ischemia-induced and reperfusion-induced arrhythmias and myocardial infarct size in anesthetized albino rabbits." | 7.72 | Selective mitochondrial KATP channel activation by nicorandil and 3-pyridyl pinacidil results in antiarrhythmic effect in an anesthetized rabbit model of myocardial ischemia/reperfusion. ( Das, B; Sarkar, C, 2003) |
| "We investigated the effects of administration of non-hypotensive doses of ATP-sensitive K+ channel (KATP) openers (nicorandil and bimakalim), and a specific mitochondrial KATP channel blocker (5-hydroxydecanoate) prior to and during coronary occlusion as well as prior to and during post-ischemic reperfusion on survival rate, ischemia-induced and reperfusion-induced arrhythmias and myocardial infarct size in anesthetized albino rabbits." | 7.71 | Effects of administration of nicorandil or bimakalim prior to and during ischemia or reperfusion on survival rate, ischemia/reperfusion-induced arrhythmias and infarct size in anesthetized rabbits. ( Das, B; Karanth, KS; Sarkar, C, 2001) |
| "We investigated the effects of sodium 5-hydroxydecanoate (5-HD) on experimentally induced ischemic arrhythmia and its mechanisms of action by biochemical and electrophysiological techniques." | 7.67 | [Study of mechanism and effect of sodium 5-hydroxydecanoate on experimental ischemic ventricular arrhythmia]. ( Dabasaki, T; Funato, H; Ishikawa, H; Kayamoto, M; Niho, T; Notsu, T; Takahashi, H; Tanaka, I; Yamasaki, F; Yamazaki, M, 1987) |
| "In anesthetized rats, reperfusion arrhythmias were induced by occluding the left main coronary artery for 5 min and subsequent reperfusion." | 5.30 | Suppression of reperfusion arrhythmias by preconditioning is inhibited by an ATP-sensitive potassium channel blocker, 5-hydroxydecanoate, but not by protein kinase C blockers in the rat. ( Hasegawa, T; Kita, H; Miura, T; Shimamoto, K; Tsuchida, A, 1998) |
| "Previous clinical studies have shown that anisodamine could improve no-reflow phenomenon and prevent reperfusion arrhythmias, but whether this protective effect is related to the antagonism of the M-type cholinergic receptor or other potential mechanisms is uncertain." | 4.02 | Cardioprotective effect of anisodamine against ischemia/reperfusion injury through the mitochondrial ATP-sensitive potassium channel. ( Bai, S; Chen, T; Du, R; Er, L; Li, X; Wang, X; Wu, H; Zhang, L, 2021) |
| " Compared with the IR-control group, both the LIPC and MIPC groups showed an amelioration of ventricular arrhythmia, reduced myocardial infarct size, increased activities of total superoxide dismutase, manganese-superoxide dismutase (Mn-SOD) and glutathione peroxidase, increased expression of Mn-SOD mRNA and decreased xanthine oxidase activity and malondialdehyde concentration." | 3.77 | Noninvasive delayed limb ischemic preconditioning attenuates myocardial ischemia-reperfusion injury in rats by a mitochondrial K(ATP) channel-dependent mechanism. ( Gao, WZ; Jiao, JJ; Kang, Y; Liu, YX; Lou, JS; Wu, YN; Yu, H; Yuan, HJ; Zhu, XH, 2011) |
| " Here, we have assessed its effects on ischaemia- and reperfusion-induced ventricular arrhythmias in vivo and a possible role for mitochondrial K(ATP) channels in these effects, using the channel inhibitor 5-hydroxydecanoate (5-HD)." | 3.74 | Peroxynitrite decreases arrhythmias induced by ischaemia reperfusion in anaesthetized dogs, without involving mitochondrial KATP channels. ( Huliák, I; Juhász, L; Kiss, A; Végh, A, 2008) |
| " In the present study, we sought to investigate the effects of administration of ATP-sensitive K(+) channel (K(ATP)) openers (nicorandil and minoxidil), a specific mitochondrial K(ATP) channel blocker (5-hydroxydecanoate (5-HD)) and a specific sarcolemmal K(ATP) channel blocker (HMR 1883; (1-[5-[2-(5-chloro-o-anisamido)ethyl]-2-methoxyphenyl]sulfonyl-3-methylthiourea) prior to coronary occlusion as well as prior to post-ischemic reperfusion on survival rate, ischemia-induced and reperfusion-induced arrhythmias and myocardial infarct size in anesthetized albino rabbits." | 3.73 | Is the sarcolemmal or mitochondrial K(ATP) channel activation important in the antiarrhythmic and cardioprotective effects during acute ischemia/reperfusion in the intact anesthetized rabbit model? ( Das, B; Sarkar, C, 2005) |
| " In the present study, we investigated the effects of the administration of non-hypotensive doses of ATP-sensitive K+ channel (KATP) openers (nicorandil and 3-pyridyl pinacidil), a specific mitochondrial KATP channel blocker (5-hydroxydecanoate) and a specific sarcolemmal KATP channel blocker (HMR 1883; 1-[5-[2-(5-chloro-o-anisamido)ethyl]-2-methoxyphenyl]sulfonyl-3- methylthiourea) prior to and during coronary occlusion, as well as prior to and during post-ischemic reperfusion, on survival rate, ischemia-induced and reperfusion-induced arrhythmias and myocardial infarct size in anesthetized albino rabbits." | 3.72 | Selective mitochondrial KATP channel activation by nicorandil and 3-pyridyl pinacidil results in antiarrhythmic effect in an anesthetized rabbit model of myocardial ischemia/reperfusion. ( Das, B; Sarkar, C, 2003) |
| " In the present study, we investigated the effects of administration of non-hypotensive doses of ATP-sensitive K(+) channel (K(ATP)) openers (nicorandil and cromakalim), a specific mitochondrial K(ATP) channel blocker (5-hydroxydecanoate (5-HD)) and a specific sarcolemmal K(ATP) channel blocker (HMR 1883; (1-[5-[2-(5-chloro-o-anisamido)ethyl]-2-methoxyphenyl]sulfonyl-3-methylthiourea) prior to and during coronary occlusion as well as prior to and during post-ischemic reperfusion on survival rate, ischemia-induced and reperfusion-induced arrhythmias and myocardial infarct size in anesthetized albino rabbits." | 3.72 | Mitochondrial K ATP channel activation is important in the antiarrhythmic and cardioprotective effects of non-hypotensive doses of nicorandil and cromakalim during ischemia/reperfusion: a study in an intact anesthetized rabbit model. ( Das, B; Sarkar, C, 2003) |
| "We investigated the effects of administration of non-hypotensive doses of ATP-sensitive K+ channel (KATP) openers (nicorandil and bimakalim), and a specific mitochondrial KATP channel blocker (5-hydroxydecanoate) prior to and during coronary occlusion as well as prior to and during post-ischemic reperfusion on survival rate, ischemia-induced and reperfusion-induced arrhythmias and myocardial infarct size in anesthetized albino rabbits." | 3.71 | Effects of administration of nicorandil or bimakalim prior to and during ischemia or reperfusion on survival rate, ischemia/reperfusion-induced arrhythmias and infarct size in anesthetized rabbits. ( Das, B; Karanth, KS; Sarkar, C, 2001) |
| "We investigated the effects of administration of non-hypotensive doses of ATP-sensitive K+ channel (K(ATP)) openers (nicorandil and aprikalim), and a specific mitochondrial K(ATP) channel blocker (5-hydroxydecanoate) prior to and during coronary occlusion as well as prior to and during post-ischemic reperfusion on survival rate, ischemia/reperfusion-induced arrhythmias and myocardial infarct size in anesthetized albino rabbits." | 3.71 | Selective mitochondrial K(ATP) channel activation results in antiarrhythmic effect during experimental myocardial ischemia/reperfusion in anesthetized rabbits. ( Das, B; Karanth, KS; Sarkar, C, 2002) |
| "We investigated the effects of sodium 5-hydroxydecanoate (5-HD) on experimentally induced ischemic arrhythmia and its mechanisms of action by biochemical and electrophysiological techniques." | 3.67 | [Study of mechanism and effect of sodium 5-hydroxydecanoate on experimental ischemic ventricular arrhythmia]. ( Dabasaki, T; Funato, H; Ishikawa, H; Kayamoto, M; Niho, T; Notsu, T; Takahashi, H; Tanaka, I; Yamasaki, F; Yamazaki, M, 1987) |
| "Arrhythmias were assessed based on the Lambeth convention and were categorized as number, duration and incidence of ventricular tachycardia (VT), ventricular fibrillation (VF), and premature ventricular complexes (PVC), and arrhythmic score." | 1.40 | Anti-arrhythmic effect of diosgenin in reperfusion-induced myocardial injury in a rat model: activation of nitric oxide system and mitochondrial KATP channel. ( Badalzadeh, R; Ebrahimi, H; Majidinia, M; Yousefi, B, 2014) |
| "Control animals had an average arrhythmia score of 10." | 1.31 | Opioid-induced cardioprotection against myocardial infarction and arrhythmias: mitochondrial versus sarcolemmal ATP-sensitive potassium channels. ( Fryer, RM; Gross, GJ; Hsu, AK; Nagase, H, 2000) |
| "In anesthetized rats, reperfusion arrhythmias were induced by occluding the left main coronary artery for 5 min and subsequent reperfusion." | 1.30 | Suppression of reperfusion arrhythmias by preconditioning is inhibited by an ATP-sensitive potassium channel blocker, 5-hydroxydecanoate, but not by protein kinase C blockers in the rat. ( Hasegawa, T; Kita, H; Miura, T; Shimamoto, K; Tsuchida, A, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.35) | 18.7374 |
| 1990's | 3 (13.04) | 18.2507 |
| 2000's | 14 (60.87) | 29.6817 |
| 2010's | 4 (17.39) | 24.3611 |
| 2020's | 1 (4.35) | 2.80 |
| Authors | Studies |
|---|---|
| Bai, S | 1 |
| Wang, X | 1 |
| Wu, H | 1 |
| Chen, T | 1 |
| Li, X | 2 |
| Zhang, L | 1 |
| Er, L | 1 |
| Du, R | 1 |
| Badalzadeh, R | 1 |
| Yousefi, B | 1 |
| Majidinia, M | 1 |
| Ebrahimi, H | 1 |
| Altunkaynak, HO | 1 |
| Tecder-Unal, M | 1 |
| Baharvand, B | 1 |
| Dehaj, ME | 1 |
| Rasoulian, B | 1 |
| Namdari, M | 1 |
| Shikhani, Y | 1 |
| Kiani, AA | 1 |
| Kiss, A | 1 |
| Juhász, L | 1 |
| Huliák, I | 1 |
| Végh, A | 2 |
| Maslov, LN | 1 |
| Lishmanov, YB | 1 |
| Oeltgen, PR | 1 |
| Barzakh, EI | 1 |
| Krylatov, AV | 1 |
| Govindaswami, M | 1 |
| Brown, SA | 1 |
| Quindry, JC | 1 |
| Schreiber, L | 1 |
| Hosick, P | 1 |
| Wrieden, J | 1 |
| Irwin, JM | 1 |
| Hoyt, E | 1 |
| Wu, YN | 1 |
| Yu, H | 1 |
| Zhu, XH | 1 |
| Yuan, HJ | 1 |
| Kang, Y | 1 |
| Jiao, JJ | 1 |
| Gao, WZ | 1 |
| Liu, YX | 1 |
| Lou, JS | 1 |
| Gross, GJ | 2 |
| Parratt, JR | 1 |
| Headrick, JP | 1 |
| Willems, L | 1 |
| Ashton, KJ | 1 |
| Holmgren, K | 1 |
| Peart, J | 1 |
| Matherne, GP | 1 |
| Das, B | 5 |
| Sarkar, C | 5 |
| Gok, S | 1 |
| Vural, K | 1 |
| Sekuri, C | 1 |
| Onur, R | 1 |
| Tezcan, A | 1 |
| Izanli, A | 1 |
| Moritani, K | 1 |
| Miyazaki, T | 1 |
| Miyoshi, S | 1 |
| Asanagi, M | 1 |
| Zhao, LS | 1 |
| Mitamura, H | 1 |
| Ogawa, S | 1 |
| Kita, H | 1 |
| Miura, T | 1 |
| Tsuchida, A | 1 |
| Hasegawa, T | 1 |
| Shimamoto, K | 1 |
| Wolk, R | 1 |
| Cobbe, SM | 1 |
| Kane, KA | 1 |
| Hicks, MN | 1 |
| Fryer, RM | 1 |
| Hsu, AK | 1 |
| Nagase, H | 1 |
| Karanth, KS | 2 |
| Tsai, CH | 1 |
| Su, SF | 1 |
| Chou, TF | 1 |
| Lee, TM | 1 |
| Niho, T | 1 |
| Notsu, T | 1 |
| Ishikawa, H | 1 |
| Funato, H | 1 |
| Yamazaki, M | 1 |
| Takahashi, H | 1 |
| Tanaka, I | 1 |
| Kayamoto, M | 1 |
| Dabasaki, T | 1 |
| Yamasaki, F | 1 |
23 other studies available for 5-hydroxydecanoate and Arrhythmias, Cardiac
| Article | Year |
|---|---|
Cardioprotective effect of anisodamine against ischemia/reperfusion injury through the mitochondrial ATP-sensitive potassium channel.
Topics: Adenosine Triphosphate; Animals; Arrhythmias, Cardiac; Cardiotonic Agents; Decanoic Acids; Energy Me | 2021 |
Anti-arrhythmic effect of diosgenin in reperfusion-induced myocardial injury in a rat model: activation of nitric oxide system and mitochondrial KATP channel.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cardiotonic Agents; Decanoic Acids; Diosgenin | 2014 |
The role of mitochondrial ATP-sensitive potassium channels on cardiovascular effects of thiopental and ketamine in rats.
Topics: Anesthetics, Dissociative; Anesthetics, Intravenous; Animals; Arrhythmias, Cardiac; Arterial Pressur | 2015 |
Delayed anti-arrhythmic effect of nitroglycerin in anesthetized rats: involvement of CGRP, PKC and mK ATP channels.
Topics: Anesthesia; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Benzophenanthridines; Calcitonin | 2009 |
Peroxynitrite decreases arrhythmias induced by ischaemia reperfusion in anaesthetized dogs, without involving mitochondrial KATP channels.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Coronary Vessels; Decanoic Acids; Dogs; Femal | 2008 |
Activation of peripheral delta2 opioid receptors increases cardiac tolerance to ischemia/reperfusion injury Involvement of protein kinase C, NO-synthase, KATP channels and the autonomic nervous system.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Autonomic Nervous System; Benzophenanthridine | 2009 |
Mitochondrial KATP channel inhibition blunts arrhythmia protection in ischemic exercised hearts.
Topics: Animals; Arrhythmias, Cardiac; Benzamides; Catalase; Decanoic Acids; Disease Models, Animal; Electro | 2010 |
Noninvasive delayed limb ischemic preconditioning attenuates myocardial ischemia-reperfusion injury in rats by a mitochondrial K(ATP) channel-dependent mechanism.
Topics: Animals; Arrhythmias, Cardiac; Decanoic Acids; Glutathione Peroxidase; Hydroxy Acids; Ischemic Preco | 2011 |
The role of mitochondrial K(ATP) channels in the antiarrhythmic effects of ischaemic preconditioning in dogs.
Topics: Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; Arrhythmias, Cardiac; Decanoic Acids; Diaz | 2002 |
The role of mitochondrial K(ATP) channels in antiarrhythmic effects of ischaemic preconditioning in dogs.
Topics: Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; Arrhythmias, Cardiac; Decanoic Acids; Diaz | 2002 |
Ischaemic tolerance in aged mouse myocardium: the role of adenosine and effects of A1 adenosine receptor overexpression.
Topics: Adenosine; Adenosine A1 Receptor Antagonists; Aging; Alkaloids; Animals; Arrhythmias, Cardiac; Benzo | 2003 |
Selective mitochondrial KATP channel activation by nicorandil and 3-pyridyl pinacidil results in antiarrhythmic effect in an anesthetized rabbit model of myocardial ischemia/reperfusion.
Topics: Animals; Anti-Arrhythmia Agents; Antioxidants; Arrhythmias, Cardiac; Blood Pressure; Decanoic Acids; | 2003 |
Mitochondrial K ATP channel activation is important in the antiarrhythmic and cardioprotective effects of non-hypotensive doses of nicorandil and cromakalim during ischemia/reperfusion: a study in an intact anesthetized rabbit model.
Topics: Analysis of Variance; Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; Arrhythmias, Cardiac | 2003 |
Is the sarcolemmal or mitochondrial K(ATP) channel activation important in the antiarrhythmic and cardioprotective effects during acute ischemia/reperfusion in the intact anesthetized rabbit model?
Topics: Anesthesia; Animals; Anti-Arrhythmia Agents; Antioxidants; Arrhythmias, Cardiac; ATP-Binding Cassett | 2005 |
Effects of the blockade of cardiac sarcolemmal ATP-sensitive potassium channels on arrhythmias and coronary flow in ischemia-reperfusion model in isolated rat hearts.
Topics: Animals; Arrhythmias, Cardiac; Benzamides; Coronary Circulation; Decanoic Acids; Dose-Response Relat | 2006 |
Blockade of ATP-sensitive potassium channels by 5-hydroxydecanoate suppresses monophasic action potential shortening during regional myocardial ischemia.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bl | 1994 |
Suppression of reperfusion arrhythmias by preconditioning is inhibited by an ATP-sensitive potassium channel blocker, 5-hydroxydecanoate, but not by protein kinase C blockers in the rat.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Decanoic Acids; Hemod | 1998 |
Relevance of inter- and intraventricular electrical dispersion to arrhythmogenesis in normal and ischaemic rabbit myocardium: a study with cromakalim, 5-hydroxydecanoate and glibenclamide.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Coronary Disease; Cromakal | 1999 |
Opioid-induced cardioprotection against myocardial infarction and arrhythmias: mitochondrial versus sarcolemmal ATP-sensitive potassium channels.
Topics: Adenosine Triphosphate; Analgesics, Opioid; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; B | 2000 |
Effects of administration of nicorandil or bimakalim prior to and during ischemia or reperfusion on survival rate, ischemia/reperfusion-induced arrhythmias and infarct size in anesthetized rabbits.
Topics: Animals; Antihypertensive Agents; Arrhythmias, Cardiac; Benzopyrans; Blood Gas Analysis; Coronary Di | 2001 |
Selective mitochondrial K(ATP) channel activation results in antiarrhythmic effect during experimental myocardial ischemia/reperfusion in anesthetized rabbits.
Topics: Anesthesia; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Blood Gas Analysis; Blood Pressur | 2002 |
Differential effects of sarcolemmal and mitochondrial K(ATP) channels activated by 17 beta-estradiol on reperfusion arrhythmias and infarct sizes in canine hearts.
Topics: Acute Disease; Animals; Arrhythmias, Cardiac; Benzamides; Blood Pressure; Decanoic Acids; Dogs; Elec | 2002 |
[Study of mechanism and effect of sodium 5-hydroxydecanoate on experimental ischemic ventricular arrhythmia].
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Coronary Disease; Decanoic Acids; Dogs; Energ | 1987 |