5-hydroxy-7-(4-hydroxy-3-methoxyphenyl)-1-phenyl-3--heptanone and Hyperlipidemias

A pancreatic lipase inhibitor, 5-hydroxy-7-(4'-hydroxy-3'-methoxyphenyl)-1-phenyl-3-heptanone (HPH), from the rhizome of Alpinia officinarum (AO) was isolated and its antihyperlipidemic activity was measured. HPH inhibited a pancreatic lipase with an IC(50) value of 1.5 mg/ml (triolein as a substrate). HPH significantly lowered the serum TG level in corn oil feeding-induced triglyceridemic mice, and reduced serum triglyceride (TG) and cholesterol in Triton WR-1339-induced hyperlipidemic mice. However, HPH did not show hypolipidemic activity in high cholesterol diet-induced hyperlipidemic mice. Based on these findings, we propose that PL inhibitors may be effective as hypolipidemic agents.

Topics: Alpinia; Animals; Cholesterol; Cholesterol, LDL; Corn Oil; Enzyme Inhibitors; Heptanes; Hyperlipidemias; Indicators and Reagents; Lipids; Male; Mice; Mice, Inbred ICR; Pancrelipase; Plant Roots; Polyethylene Glycols; Triglycerides