5-hydroxy-6-8-11-14-eicosatetraenoic-acid has been researched along with Arteriosclerosis* in 2 studies
2 other study(ies) available for 5-hydroxy-6-8-11-14-eicosatetraenoic-acid and Arteriosclerosis
| Article | Year |
|---|---|
Increased production of lipoxygenase products by cholesterol-rich mouse macrophages.
The metabolism of arachidonic acid by cholesterol-enriched resident mouse peritoneal macrophages was investigated. The amounts of monohydroxyeicosatetraenoic acid (mono-HETE) produced by the cholesterol-rich macrophages were 2.5-fold greater when compared to control macrophages. The major lipoxygenase product, identified by high-performance liquid chromatography in both macrophages was 12-HETE. Since macrophages are important participants in the formation of atheromatous lesions, the increased metabolism of arachidonic acid to HETE products by cholesterol-rich macrophages could contribute to the initiation and progression of the atherosclerotic process. Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Animals; Arachidonic Acids; Arteriosclerosis; Cells, Cultured; Cholesterol; Chromatography, Thin Layer; Cyclooxygenase Inhibitors; Hydroxyeicosatetraenoic Acids; Ibuprofen; Indomethacin; Lipoxygenase; Macrophages; Male; Mice | 1985 |
Comparative effect of lipoxygenase products of arachidonic acid on rat aortic smooth muscle cell migration.
We investigated the effects of mono-hydroxyeicosatetraenoic acids (HETEs) and N-formyl-methionyl-leucyl-phenylalanine (F-Met-Leu-Phe) on rat aortic smooth muscle cell migration in modified Boyden chambers. 12-HETE showed the most potent stimulatory effect on smooth muscle cell migration among the mono-HETEs tested. The optimal concentrations for cell migration were 3 X 10(-15) and 3 X 10(-13) g/ml for 12-HETE and 10(-8) g/ml for 15-HETE, 5-HETE and F-Met-Leu-Phe were inactive with these cells. As 12-HETE is biosynthesized from arachidonic acid by the 12-lipoxygenase pathway in platelets and macrophages, and 15-HETE by the 15-lipoxygenase pathway in granulocytes, the present results indicate an important role for such cells in the early phase of atherosclerosis. Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Animals; Aorta; Arachidonate Lipoxygenases; Arachidonic Acids; Arteriosclerosis; Cell Movement; Granulocytes; Hydroxyeicosatetraenoic Acids; Lipoxygenase; Muscle, Smooth, Vascular; N-Formylmethionine; N-Formylmethionine Leucyl-Phenylalanine; Oligopeptides; Rats | 1982 |