5-hydroxy-6-8-11-14-17-eicosapentaenoic-acid and Overweight

Marine n-3 polyunsaturated fatty acids (PUFA) have a variety of anti-inflammatory properties. This study evaluated the effect of n-3 PUFA in a low, but recommended cardioprotective dosage on the formation of 5-lipoxygenase pathway metabolites in overweight subjects.. Fifty subjects were randomized to 1.1g of n-3 PUFA or olive oil for 6 weeks.. Leukotriene B(4) formation decreased by 14% in the n-3 PUFA group which proved to be significant within the group (p=0.005) but not between groups (p=0.25). The formation of 5-hydroxyeicosatetraenoic acid (5-HETE) did not differ significantly between the groups. In the n-3 PUFA group, both 5-hydroxyeicosapentaenoic (5-HEPE) acid and leukotriene B(5) increased significantly compared to the control group (p<0.001).. In conclusion, we did not observe any significant net anti-inflammatory effect on the 5-lipoxygenase pathway from a daily supplement of 1.1g marine n-3 PUFA for 6 weeks.

Topics: Aged; Anti-Inflammatory Agents; Arachidonate 5-Lipoxygenase; Cardiotonic Agents; Cell Membrane; Double-Blind Method; Eicosapentaenoic Acid; Fatty Acids, Omega-3; Female; Humans; Hydroxyeicosatetraenoic Acids; Leukotriene B4; Male; Middle Aged; Multivariate Analysis; Neutrophils; Obesity, Abdominal; Overweight; Treatment Outcome