Compounds > 5-ethoxycarbonyl-5-methyl-1-pyrroline-n-oxide

5-ethoxycarbonyl-5-methyl-1-pyrroline-n-oxide and Neoplasms

5-ethoxycarbonyl-5-methyl-1-pyrroline-n-oxide has been researched along with Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for 5-ethoxycarbonyl-5-methyl-1-pyrroline-n-oxide and Neoplasms

Article	Year
Cytotoxicity of the novel spin trapping compound 5-ethoxycarbonyl-3,5-dimethyl-pyrroline N-oxide (3,5-EDPO) and its derivatives. Bioorganic & medicinal chemistry letters, 2007, Oct-15, Volume: 17, Issue:20 ESR spin trapping allows detection of superoxide radicals. Novel spin traps forming more stable superoxide adducts (t(1/2) ca. 12-55 min) were tested for their toxicity to cultured cells. The following toxicity ranking was obtained: 4,5-DPPO>4-BEMPO approximately 3-BEMPO>trans-3,5-EDPO>3,5-DPPO approximately 4,5-DiPPO approximately 4,5-EDPO>cis-3,5-EDPO approximately 3,5-DiPPO>DEPMPO. In conclusion, 4,5-EDPO, cis-3,5-EDPO and 3,5-DiPPO can be recommended for further investigation of superoxide in biological systems. Topics: Animals; Antineoplastic Agents; Cell Proliferation; Cells, Cultured; Cyclic N-Oxides; Hepatocytes; Humans; Hydro-Lyases; Isomerism; Molecular Structure; Neoplasms; Oxides; Rats; Spin Trapping; Structure-Activity Relationship; Superoxides	2007

Article

Year

Cytotoxicity of the novel spin trapping compound 5-ethoxycarbonyl-3,5-dimethyl-pyrroline N-oxide (3,5-EDPO) and its derivatives.

Bioorganic & medicinal chemistry letters, 2007, Oct-15, Volume: 17, Issue:20

ESR spin trapping allows detection of superoxide radicals. Novel spin traps forming more stable superoxide adducts (t(1/2) ca. 12-55 min) were tested for their toxicity to cultured cells. The following toxicity ranking was obtained: 4,5-DPPO>4-BEMPO approximately 3-BEMPO>trans-3,5-EDPO>3,5-DPPO approximately 4,5-DiPPO approximately 4,5-EDPO>cis-3,5-EDPO approximately 3,5-DiPPO>DEPMPO. In conclusion, 4,5-EDPO, cis-3,5-EDPO and 3,5-DiPPO can be recommended for further investigation of superoxide in biological systems.

Topics: Animals; Antineoplastic Agents; Cell Proliferation; Cells, Cultured; Cyclic N-Oxides; Hepatocytes; Humans; Hydro-Lyases; Isomerism; Molecular Structure; Neoplasms; Oxides; Rats; Spin Trapping; Structure-Activity Relationship; Superoxides

2007