5-doxylstearate and Psoriasis

5-doxylstearate has been researched along with Psoriasis* in 2 studies

Trials

1 trial(s) available for 5-doxylstearate and Psoriasis

Article	Year
EPR spectroscopic investigation of psoriatic finger nails. Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI), 2013, Volume: 19, Issue:4 Nail lesions are common features of psoriasis and found in almost half of the patients. However, there is no feasible spectroscopic method evaluating changes and severity of nail psoriasis. EPR (electron paramagnetic resonance) might be feasible for evaluating nail conditions in the patients of psoriasis.. Finger nails of five cases with nail psoriasis, (three females and two males) were examined. Nail samples were subjected to the EPR assay. The small piece of the finger nail (1.5 × 5 mm(2)) was incubated in ~50 μM 5-DSA (5-doxylstearic acid) aqueous solutions for about 60 min at 37°C. After rinsing and wiping off the excess 5-DSA solution, the nail samples were measured by EPR.. EPR spectra were analyzed using the intensity ratio (Fast/Slow) of the two motions at the peaks of the lower magnetic field. We observed two distinguishable sites on the basis of the EPR results. In addition, the modern EPR calculation was performed to analyze the spectra obtained. The nail psoriasis-related region is 2~3 times higher than that of the control.. The present EPR results show that there are two distinguishable sites in the nail. In the case of nail psoriasis, the fragile components are 2~3 times more than those of the control. Thus, the EPR method is thought to be a novel and reliable method of evaluating the nail psoriasis. Topics: Aged; Cyclic N-Oxides; Electron Spin Resonance Spectroscopy; Feasibility Studies; Female; Humans; Male; Middle Aged; Models, Biological; Nail Diseases; Nails; Psoriasis; Reproducibility of Results; Severity of Illness Index	2013

Article

Year

EPR spectroscopic investigation of psoriatic finger nails.

Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI), 2013, Volume: 19, Issue:4

Nail lesions are common features of psoriasis and found in almost half of the patients. However, there is no feasible spectroscopic method evaluating changes and severity of nail psoriasis. EPR (electron paramagnetic resonance) might be feasible for evaluating nail conditions in the patients of psoriasis.. Finger nails of five cases with nail psoriasis, (three females and two males) were examined. Nail samples were subjected to the EPR assay. The small piece of the finger nail (1.5 × 5 mm(2)) was incubated in ~50 μM 5-DSA (5-doxylstearic acid) aqueous solutions for about 60 min at 37°C. After rinsing and wiping off the excess 5-DSA solution, the nail samples were measured by EPR.. EPR spectra were analyzed using the intensity ratio (Fast/Slow) of the two motions at the peaks of the lower magnetic field. We observed two distinguishable sites on the basis of the EPR results. In addition, the modern EPR calculation was performed to analyze the spectra obtained. The nail psoriasis-related region is 2~3 times higher than that of the control.. The present EPR results show that there are two distinguishable sites in the nail. In the case of nail psoriasis, the fragile components are 2~3 times more than those of the control. Thus, the EPR method is thought to be a novel and reliable method of evaluating the nail psoriasis.

Topics: Aged; Cyclic N-Oxides; Electron Spin Resonance Spectroscopy; Feasibility Studies; Female; Humans; Male; Middle Aged; Models, Biological; Nail Diseases; Nails; Psoriasis; Reproducibility of Results; Severity of Illness Index

2013

Other Studies

1 other study(ies) available for 5-doxylstearate and Psoriasis

Article	Year
Photophysical alterations of erythrocyte membrane by 4,5',8-trimethyl psoralen: membrane response towards psoralen phototherapy. Biochemical and biophysical research communications, 1994, Mar-30, Volume: 199, Issue:3 Despite the wide and versatile use of psoralen phototherapy in various dermal diseases including psoriasis and leukoderma, the proposed mechanism of action of psoralen is disputed. This study launches an original documentation of free-radical resulting in erythrocyte membrane damage studied by spin-labeling using the probes malnet and 5 doxyl stearate as protein and lipid domains, respectively. Both Type I and Type II photodynamics appear plausible and the therapeutic aspects of this innovation are being verified. Topics: Animals; Cyclic N-Oxides; Electron Spin Resonance Spectroscopy; Erythrocyte Membrane; Ethylmaleimide; Free Radicals; Humans; Male; Membrane Lipids; Membrane Proteins; Methoxsalen; Phototherapy; Psoriasis; Rats; Skin Diseases; Spin Labels; Superoxides; Ultraviolet Rays	1994

Article

Year

Photophysical alterations of erythrocyte membrane by 4,5',8-trimethyl psoralen: membrane response towards psoralen phototherapy.

Biochemical and biophysical research communications, 1994, Mar-30, Volume: 199, Issue:3

Despite the wide and versatile use of psoralen phototherapy in various dermal diseases including psoriasis and leukoderma, the proposed mechanism of action of psoralen is disputed. This study launches an original documentation of free-radical resulting in erythrocyte membrane damage studied by spin-labeling using the probes malnet and 5 doxyl stearate as protein and lipid domains, respectively. Both Type I and Type II photodynamics appear plausible and the therapeutic aspects of this innovation are being verified.

Topics: Animals; Cyclic N-Oxides; Electron Spin Resonance Spectroscopy; Erythrocyte Membrane; Ethylmaleimide; Free Radicals; Humans; Male; Membrane Lipids; Membrane Proteins; Methoxsalen; Phototherapy; Psoriasis; Rats; Skin Diseases; Spin Labels; Superoxides; Ultraviolet Rays

1994