5-dimethylamiloride has been researched along with Myocardial Ischemia in 11 studies
5-dimethylamiloride: has anti-HIV-1 activity
Myocardial Ischemia: A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).
| Excerpt | Relevance | Reference |
|---|---|---|
| "The inhibition of Na(+)-H+ exchange (NHE) with amiloride analogues in vitro has been shown to prevent reperfusion arrhythmias and additional cell necrosis." | 3.69 | Role of Na(+)-H+ exchange on reperfusion related myocardial injury and arrhythmias in an open-chest swine model. ( Fukuta, M; Iwa, T; Kobayashi, T; Uesugi, M; Wakida, Y, 1996) |
| "Amiloride analogs block Na+/H+ exchange and thereby protect the heart from myocardial ischemia-reperfusion injury." | 3.69 | Myocardial dysfunction is associated with activation of Na+/H+ exchange immediately during reperfusion. ( Maddaford, TG; Pierce, GN, 1997) |
| "Treatment with tetrodotoxin or dimethylamirolide (DMA) dose-dependently attenuated the ischemia- and reperfusion-induced increase in myocardial sodium and enhanced the post-ischemic recovery of the LVDP." | 1.31 | Contribution of sodium channel and sodium/hydrogen exchanger to sodium accumulation in the ischemic myocardium. ( Kajiwara, H; Takasaki, A; Takeo, S; Tanonaka, K, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 8 (72.73) | 18.2507 |
| 2000's | 3 (27.27) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Marina Prendes, MG | 1 |
| García, JV | 1 |
| Testoni, G | 1 |
| Fernández, MA | 1 |
| Perazzo, JC | 1 |
| Savino, EA | 1 |
| Varela, A | 1 |
| Karwatowska-Prokopczuk, E | 1 |
| Czarnowska, E | 1 |
| Prokopczuk, A | 1 |
| Counillon, L | 1 |
| Scholz, W | 1 |
| Lang, HJ | 1 |
| Pouysségur, J | 1 |
| Shimada, Y | 1 |
| Hearse, DJ | 1 |
| Avkiran, M | 1 |
| Liu, B | 1 |
| Clanachan, AS | 1 |
| Schulz, R | 1 |
| Lopaschuk, GD | 1 |
| Fukuta, M | 1 |
| Wakida, Y | 1 |
| Iwa, T | 1 |
| Uesugi, M | 1 |
| Kobayashi, T | 1 |
| Maddaford, TG | 1 |
| Pierce, GN | 1 |
| Gabel, SA | 1 |
| Cross, HR | 1 |
| London, RE | 1 |
| Steenbergen, C | 1 |
| Murphy, E | 1 |
| Abete, P | 1 |
| Ferrara, P | 1 |
| Bianco, S | 1 |
| Calabrese, C | 1 |
| Napoli, C | 1 |
| Cacciatore, F | 1 |
| Ferrara, N | 1 |
| Rengo, F | 1 |
| Tanonaka, K | 1 |
| Takasaki, A | 1 |
| Kajiwara, H | 1 |
| Takeo, S | 1 |
| Takeuchi, Y | 1 |
| Kihara, Y | 1 |
| Inagaki, K | 1 |
| Yoneda, T | 1 |
| Sasayama, S | 1 |
11 other studies available for 5-dimethylamiloride and Myocardial Ischemia
| Article | Year |
|---|---|
Influence of fasting on the effects of dimethylamiloride and oxfenicine on ischaemic-reperfused rat hearts.
Topics: Amiloride; Animals; Carnitine O-Palmitoyltransferase; Cell Survival; Enzyme Inhibitors; Fasting; Fat | 2006 |
Combined therapy with dimethylthiourea, diltiazem and amiloride/dimethylamiloride in the ischemic/reperfused heart.
Topics: Amiloride; Animals; Diltiazem; Dose-Response Relationship, Drug; Drug Therapy, Combination; Endocard | 1995 |
Pharmacological characterization of stably transfected Na+/H+ antiporter isoforms using amiloride analogs and a new inhibitor exhibiting anti-ischemic properties.
Topics: Amiloride; Animals; Cell Line; Cricetinae; Cricetulus; DNA, Complementary; Guanidines; Myocardial Is | 1993 |
Impact of extracellular buffer composition on cardioprotective efficacy of Na+/H+ exchanger inhibitors.
Topics: Amiloride; Animals; Bicarbonates; Buffers; Dose-Response Relationship, Drug; Extracellular Space; Gu | 1996 |
Cardiac efficiency is improved after ischemia by altering both the source and fate of protons.
Topics: Acetyl Coenzyme A; Adenosine Triphosphate; Amiloride; Animals; Dichloroacetic Acid; Glucose; Glycoly | 1996 |
Role of Na(+)-H+ exchange on reperfusion related myocardial injury and arrhythmias in an open-chest swine model.
Topics: Action Potentials; Amiloride; Animals; Arrhythmias, Cardiac; Calcium; Cardiac Pacing, Artificial; Co | 1996 |
Myocardial dysfunction is associated with activation of Na+/H+ exchange immediately during reperfusion.
Topics: Amiloride; Animals; Cardiotonic Agents; In Vitro Techniques; Male; Myocardial Contraction; Myocardia | 1997 |
Decreased intracellular pH is not due to increased H+ extrusion in preconditioned rat hearts.
Topics: Amiloride; Animals; Heart; Ischemic Preconditioning, Myocardial; Male; Myocardial Contraction; Myoca | 1997 |
Age-related effects of acidosis in isolated cardiac muscle.
Topics: Acidosis; Aging; Amiloride; Analysis of Variance; Animals; Arrhythmias, Cardiac; Diastole; Diuretics | 1998 |
Contribution of sodium channel and sodium/hydrogen exchanger to sodium accumulation in the ischemic myocardium.
Topics: Amiloride; Animals; In Vitro Techniques; Ions; Male; Myocardial Contraction; Myocardial Ischemia; My | 2000 |
Endothelin-1 has a unique oxygen-saving effect by increasing contractile efficiency in the isolated rat heart.
Topics: Amiloride; Animals; Antihypertensive Agents; Caffeic Acids; Cardiotonic Agents; Drug Interactions; E | 2001 |