5-dimethylamiloride has been researched along with Amyotrophic Lateral Sclerosis in 1 studies
5-dimethylamiloride: has anti-HIV-1 activity
Amyotrophic Lateral Sclerosis: A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Behan, AT | 1 |
| Breen, B | 1 |
| Hogg, M | 1 |
| Woods, I | 1 |
| Coughlan, K | 1 |
| Mitchem, M | 1 |
| Prehn, JH | 1 |
1 other study available for 5-dimethylamiloride and Amyotrophic Lateral Sclerosis
| Article | Year |
|---|---|
Acidotoxicity and acid-sensing ion channels contribute to motoneuron degeneration.
Topics: Acid Sensing Ion Channels; Acids; Amiloride; Amyotrophic Lateral Sclerosis; Animals; Apoptosis; Cell | 2013 |