5-dimethylamiloride has been researched along with Acidosis in 13 studies
5-dimethylamiloride: has anti-HIV-1 activity
Acidosis: A pathologic condition of acid accumulation or depletion of base in the body. The two main types are RESPIRATORY ACIDOSIS and metabolic acidosis, due to metabolic acid build up.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim was to investigate the effects of slowing the recovery of ischaemia induced intracellular acidosis with hypercapnic acidosis or dimethyl amiloride (DMA) on the extent of reperfusion induced cell death." | 7.69 | Hypercapnic acidosis and dimethyl amiloride reduce reperfusion induced cell death in ischaemic ventricular myocardium. ( Cascio, WE; Gilliam, DE; Kaplan, SH; Lemasters, JJ; Shen, J; Yang, H, 1995) |
| "A series of amiloride derivatives modified at the 5-position of the pyrazine ring were evaluated as inhibitors of acid-sensing ion channel-3 (ASIC3), a novel target for the treatment of chronic pain." | 3.75 | Amiloride derived inhibitors of acid-sensing ion channel-3 (ASIC3). ( Bilodeau, MT; Bock, MG; Cato, MJ; Chang, RK; Cook, SP; Di Marco, CN; Dipardo, RM; Hartman, GD; Jovanovska, A; Kane, SA; Kuduk, SD; Leitl, M; Spencer, RH; Urban, MO, 2009) |
| "The aim was to investigate the effects of slowing the recovery of ischaemia induced intracellular acidosis with hypercapnic acidosis or dimethyl amiloride (DMA) on the extent of reperfusion induced cell death." | 3.69 | Hypercapnic acidosis and dimethyl amiloride reduce reperfusion induced cell death in ischaemic ventricular myocardium. ( Cascio, WE; Gilliam, DE; Kaplan, SH; Lemasters, JJ; Shen, J; Yang, H, 1995) |
| "The effects of 5-(N,N-dimethyl)amiloride, a potent and specific Na(+)-H+ exchange inhibitor, were investigated in isolated perfused rabbit hearts subjected to ischemia and reperfusion." | 3.69 | Protective effects of dimethyl amiloride against postischemic myocardial dysfunction in rabbit hearts: phosphorus 31-nuclear magnetic resonance measurements of intracellular pH and cellular energy. ( Abe, T; Akita, T; Hotta, Y; Kodama, I; Koike, A; Murase, M; Takeya, K; Toyama, J, 1996) |
| " However, the inhibitory effect was prevented by amiloride and dimethyl-amiloride, Na(+)-H+ exchange inhibitors, or acidosis caused by the addition of HCl." | 3.69 | Hypoxia-induced inhibition of the response to nitroxidergic nerve stimulation in canine cerebral arteries. ( Ayajiki, K; Okamura, T; Toda, N, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 9 (69.23) | 18.2507 |
| 2000's | 3 (23.08) | 29.6817 |
| 2010's | 1 (7.69) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kuduk, SD | 1 |
| Di Marco, CN | 1 |
| Chang, RK | 1 |
| Dipardo, RM | 1 |
| Cook, SP | 1 |
| Cato, MJ | 1 |
| Jovanovska, A | 1 |
| Urban, MO | 1 |
| Leitl, M | 1 |
| Spencer, RH | 1 |
| Kane, SA | 1 |
| Bilodeau, MT | 1 |
| Hartman, GD | 1 |
| Bock, MG | 1 |
| Li, K | 1 |
| Su, W | 1 |
| Li, M | 1 |
| Chen, CJ | 1 |
| Li, YY | 1 |
| Lai, LY | 1 |
| Zhang, MM | 1 |
| Liu, SJ | 1 |
| Fichna, J | 1 |
| Peng, A | 1 |
| Hao, CM | 1 |
| Gu, Y | 1 |
| Lin, SY | 1 |
| Kaplan, SH | 1 |
| Yang, H | 1 |
| Gilliam, DE | 1 |
| Shen, J | 1 |
| Lemasters, JJ | 1 |
| Cascio, WE | 1 |
| Koike, A | 1 |
| Akita, T | 1 |
| Hotta, Y | 1 |
| Takeya, K | 1 |
| Kodama, I | 1 |
| Murase, M | 1 |
| Abe, T | 1 |
| Toyama, J | 1 |
| Vornov, JJ | 1 |
| Thomas, AG | 1 |
| Jo, D | 1 |
| Gotoh, M | 1 |
| Davies, SE | 1 |
| Obrenovitch, TP | 1 |
| Okamura, T | 1 |
| Ayajiki, K | 1 |
| Toda, N | 1 |
| Abete, P | 1 |
| Ferrara, P | 1 |
| Bianco, S | 1 |
| Calabrese, C | 1 |
| Napoli, C | 1 |
| Cacciatore, F | 1 |
| Ferrara, N | 1 |
| Rengo, F | 1 |
| Chiu, HM | 1 |
| Lin, HH | 1 |
| Tang, MJ | 1 |
| Choi, HS | 1 |
| Trafford, AW | 1 |
| Orchard, CH | 1 |
| Eisner, DA | 1 |
| Baron, O | 1 |
| Saiki, Y | 1 |
| Rebeyka, IM | 1 |
| Nakanishi, T | 1 |
| Seguchi, M | 1 |
| Tsuchiya, T | 1 |
| Cragoe, EJ | 1 |
| Takao, A | 1 |
| Momma, K | 1 |
| Whalley, DW | 1 |
| Hemsworth, PD | 1 |
| Rasmussen, HH | 1 |
13 other studies available for 5-dimethylamiloride and Acidosis
| Article | Year |
|---|---|
Amiloride derived inhibitors of acid-sensing ion channel-3 (ASIC3).
Topics: Acid Sensing Ion Channels; Acidosis; Amiloride; Amines; Animals; Chemistry, Pharmaceutical; Drug Des | 2009 |
Acid loading stimulates rat glomerular mesangial cells proliferation through Na(+)-H (+) exchanger isoform 1 (NHE1)-dependent pathway.
Topics: Acidosis; Amiloride; Animals; Blotting, Western; Cell Cycle; Cell Proliferation; Disease Progression | 2013 |
Hypercapnic acidosis and dimethyl amiloride reduce reperfusion induced cell death in ischaemic ventricular myocardium.
Topics: Acidosis; Amiloride; Animals; Cell Death; Hydrogen-Ion Concentration; Hypercapnia; In Vitro Techniqu | 1995 |
Protective effects of dimethyl amiloride against postischemic myocardial dysfunction in rabbit hearts: phosphorus 31-nuclear magnetic resonance measurements of intracellular pH and cellular energy.
Topics: Acidosis; Adenosine Triphosphate; Amiloride; Animals; Bicarbonates; Calcium; Calcium Chloride; Cardi | 1996 |
Protective effects of extracellular acidosis and blockade of sodium/hydrogen ion exchange during recovery from metabolic inhibition in neuronal tissue culture.
Topics: Acidosis; Amiloride; Animals; Brain Ischemia; Cells, Cultured; Cerebral Cortex; Dizocilpine Maleate; | 1996 |
Brain tissue acidosis: effects on the extracellular concentration of N-acetylaspartate.
Topics: Acid-Base Equilibrium; Acidosis; Amiloride; Ammonium Chloride; Animals; Aspartic Acid; Brain; Electr | 1997 |
Hypoxia-induced inhibition of the response to nitroxidergic nerve stimulation in canine cerebral arteries.
Topics: Acidosis; Amiloride; Animals; Cerebral Arteries; Dogs; Female; Hypoxia; Male; Nervous System Physiol | 1997 |
Age-related effects of acidosis in isolated cardiac muscle.
Topics: Acidosis; Aging; Amiloride; Analysis of Variance; Animals; Arrhythmias, Cardiac; Diastole; Diuretics | 1998 |
Ethyl isopropylamiloride downregulates Na,K-ATPase gene expression which confers cytotoxicity in primary proximal tubule cell cultures.
Topics: Acidosis; Amiloride; Animals; Anti-Arrhythmia Agents; Blotting, Northern; Cell Survival; Cells, Cult | 1998 |
The effect of acidosis on systolic Ca2+ and sarcoplasmic reticulum calcium content in isolated rat ventricular myocytes.
Topics: Acidosis; Amiloride; Animals; Butyrates; Caffeine; Calcium; Calcium Channels, L-Type; Cell Separatio | 2000 |
pH paradox and neonatal heart.
Topics: Acidosis; Amiloride; Animals; Animals, Newborn; Blood Pressure; Calcium; Diastole; Female; Heart Arr | 2001 |
Effect of partial Na pump and Na-H exchange inhibition on [Ca]i during acidosis in cardiac cells.
Topics: Acidosis; Amiloride; Animals; Calcium; Carrier Proteins; Cell Separation; Hydrogen-Ion Concentration | 1991 |
Sodium-hydrogen exchange in guinea-pig ventricular muscle during exposure to hyperosmolar solutions.
Topics: Acidosis; Alkalosis; Amiloride; Animals; Guinea Pigs; Heart Ventricles; Hydrogen-Ion Concentration; | 1991 |