Compounds > 5-chloro-6-(1-(2-iminopyrrolidinyl)-methyl)uracil-hydrochloride

5-chloro-6-(1-(2-iminopyrrolidinyl)-methyl)uracil-hydrochloride and Lymphoma--T-Cell

5-chloro-6-(1-(2-iminopyrrolidinyl)-methyl)uracil-hydrochloride has been researched along with Lymphoma--T-Cell* in 1 studies

Other Studies

1 other study(ies) available for 5-chloro-6-(1-(2-iminopyrrolidinyl)-methyl)uracil-hydrochloride and Lymphoma--T-Cell

Article	Year
Structural diversity of nucleoside phosphonic acids as a key factor in the discovery of potent inhibitors of rat T-cell lymphoma thymidine phosphorylase. Bioorganic & medicinal chemistry letters, 2010, Feb-01, Volume: 20, Issue:3 Structurally diverse, sugar-modified, thymine-containing nucleoside phosphonic acids were evaluated for their ability to inhibit thymidine phosphorylase (TP, EC 2.4.2.4) purified from spontaneous T-cell lymphomas of an inbred Sprague-Dawley rat strain. From a large set of tested compounds, among them a number of pyrrolidine-based derivatives, 10 nucleotide analogues with IC(50) values below 1 microM were selected. Out of them, four compounds strongly inhibited the enzyme with IC(50) values lying in a range of 11-45 nM. These most potent compounds might be bi-substrate analogues. Topics: Animals; Dose-Response Relationship, Drug; Humans; Inhibitory Concentration 50; Lymphoma, T-Cell; Nucleosides; Organophosphonates; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Thymidine Phosphorylase	2010

Article

Year

Structural diversity of nucleoside phosphonic acids as a key factor in the discovery of potent inhibitors of rat T-cell lymphoma thymidine phosphorylase.

Bioorganic & medicinal chemistry letters, 2010, Feb-01, Volume: 20, Issue:3

Structurally diverse, sugar-modified, thymine-containing nucleoside phosphonic acids were evaluated for their ability to inhibit thymidine phosphorylase (TP, EC 2.4.2.4) purified from spontaneous T-cell lymphomas of an inbred Sprague-Dawley rat strain. From a large set of tested compounds, among them a number of pyrrolidine-based derivatives, 10 nucleotide analogues with IC(50) values below 1 microM were selected. Out of them, four compounds strongly inhibited the enzyme with IC(50) values lying in a range of 11-45 nM. These most potent compounds might be bi-substrate analogues.

Topics: Animals; Dose-Response Relationship, Drug; Humans; Inhibitory Concentration 50; Lymphoma, T-Cell; Nucleosides; Organophosphonates; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Thymidine Phosphorylase

2010