5-carboxytetramethylrhodamine and Neoplasms

Development of luminescent probes for rapid and effective discrimination and detection of cancer cells has the potential to address the current challenges in early diagnosis and treatment monitoring of cancer diseases. In this work, we report the preparation of a unique folic acid (FA)-functionalized dual-emissive nanoprobe, CTMR@BHHBCB-Eu-FA, for steady-state and time-gated luminescence "double-check" imaging of cancer cells. The nanoprobe was engineered by covalently doping two luminescent dyes, 5-carboxytetramethylrhodamine (CTMR) and BHHBCB-Eu

Topics: Buffers; Fluorescent Dyes; Folate Receptors, GPI-Anchored; Folic Acid; HeLa Cells; Humans; Hydrogen-Ion Concentration; Luminescence; Nanoparticles; Nanotechnology; Neoplasms; Optical Imaging; Photochemistry; Rhodamines; Silicon Dioxide