5-carboxy-8-hydroxyquinoline has been researched along with Inflammation* in 2 studies
2 other study(ies) available for 5-carboxy-8-hydroxyquinoline and Inflammation
| Article | Year |
|---|---|
Epigenetic drug screen identified IOX1 as an inhibitor of Th17-mediated inflammation through targeting TET2.
Targeting helper T cells, especially Th17 cells, has become a plausible therapy for many autoimmune diseases.. Using an in vitro culture system, we screened an epigenetics compound library for inhibitors of IFN-γ and IL-17 expression in murine Th1 and Th17 cultures.. These results provide evidence of the strong potential for IOX1 as a viable therapy for inflammatory diseases, in particular of the eye.. This study was supported by the National Key Research and Development Program of China 2021YFA1101200 (2021YFA1101204) to LW and XW; the National Natural Science Foundation of China 81900844 to XH and 82171041 to LW; the China Postdoctoral Science Foundation 2021M700776 and the Scientific Research Project of Guangdong Provincial Bureau of Traditional Chinese Medicine 20221373 to YZ; and the National Institute for Health Research (NIHR) Biomedical Research Centre at Moorfields Eye Hospital NHS (National Health Service) Foundation Trust and University College London Institute of Ophthalmology, UK (DAC, LPS, PJPL, MS, ADD and RWJL). The views expressed are those of the authors and not necessarily those of the NIHR or the UK's Department of Health and Social Care. Topics: Animals; Cell Differentiation; Dioxygenases; DNA-Binding Proteins; Epigenesis, Genetic; Humans; Inflammation; Interleukin-17; Mice; State Medicine; Th1 Cells; Th17 Cells | 2022 |
Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
This protocol describes microsphere-based protease assays for use in flow cytometry and high-throughput screening. This platform measures a loss of fluorescence from the surface of a microsphere due to the cleavage of an attached fluorescent protease substrate by a suitable protease enzyme. The assay format can be adapted to any site or protein-specific protease of interest and results can be measured in both real time and as endpoint fluorescence assays on a flow cytometer. Endpoint assays are easily adapted to microplate format for flow cytometry high-throughput analysis and inhibitor screening. Topics: Animals; Biotinylation; Flow Cytometry; Fluorescence Resonance Energy Transfer; Green Fluorescent Proteins; High-Throughput Screening Assays; Humans; Inflammation; Kinetics; Microspheres; Peptide Hydrolases; Peptides; Reproducibility of Results; Temperature | 2010 |