5-carboxy-8-hydroxyquinoline and Escherichia-coli-Infections

5-carboxy-8-hydroxyquinoline has been researched along with Escherichia-coli-Infections* in 1 studies

Other Studies

1 other study(ies) available for 5-carboxy-8-hydroxyquinoline and Escherichia-coli-Infections

ArticleYear
IOX1 activity as sepsis therapy and an antibiotic against multidrug-resistant bacteria.
    Scientific reports, 2021, 02-03, Volume: 11, Issue:1

    Sepsis is caused by organ dysfunction initiated by an unrestrained host immune response to infection. The emergence of antibiotic-resistant bacteria has rapidly increased in the last decades and has stimulated a firm research platform to combat infections caused by antibiotic-resistant bacteria that cannot be eradicated with conventional antibiotics. Strategies like epigenetic regulators such as lysine demethylase (Kdm) has received attention as a new target. Thus, we sought to investigate the epigenetic mechanisms in sepsis pathophysiology with the aim of discovering new concepts for treatment. A transcriptome analysis of dendritic cells during their inflammatory state identified Kdm as a critical molecule in sepsis regulation. Next, 8-hydroxyquinoline-5-carboxylic acid (IOX1) ability to control endotoxemia induced by Lipopolysaccharide and bacterial sepsis was demonstrated. IOX1 has been shown to regulate endotoxemia and sepsis caused by Escherichia coli and carbapenem-resistant Acinetobacter baumannii and has also contributed to the suppression of multidrug-resistant bacterial growth through the inhibition of DNA Gyrase. These findings show that IOX1 could be a component agent against bacterial sepsis by functioning as a broad-spectrum antibiotic with dual effects.

    Topics: Acinetobacter baumannii; Acinetobacter Infections; Animals; Anti-Bacterial Agents; Dendritic Cells; Disease Models, Animal; DNA Gyrase; Drug Resistance, Multiple, Bacterial; Escherichia coli; Escherichia coli Infections; Female; Histone Demethylases; Humans; Hydroxyquinolines; Mice; Microbial Sensitivity Tests; Molecular Docking Simulation; Sepsis

2021