5-aminovaleric acid has been researched along with Seizures in 4 studies
5-aminovaleric acid: from red fox anal secretion; RN given refers to parent cpd
5-aminopentanoic acid : A delta-amino acid comprising pentanoic acid with an amino substituent at C-5; a methylene homologue of gamma-aminobutyric acid (GABA) that is a weak GABA agonist.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Because 5-aminovaleric acid (5-AV) has been implicated in modulation of the glutamine-glutamate-GABA metabolic pathway, we hypothesized that 5-AV would alter the expression of seizures in the MSO model of MTLE." | 7.80 | 5-aminovaleric acid suppresses the development of severe seizures in the methionine sulfoximine model of mesial temporal lobe epilepsy. ( Damisah, EC; Dhaher, R; Eid, T; Gruenbaum, BF; Gruenbaum, SE; Ong, C; Wang, H; Zaveri, HP, 2014) |
| "Pentobarbital and phenobarbital exhibited anticonvulsant effect against maximal electroshock (MES) and picrotoxin-induced seizures in rats." | 7.67 | Comparison of anticonvulsant effect of pentobarbital and phenobarbital against seizures induced by maximal electroshock and picrotoxin in rats. ( Mehta, AK; Ticku, MK, 1986) |
| "Both groups showed similar seizure frequency over days 3-21 (~1seizure/day)." | 5.40 | 5-aminovaleric acid suppresses the development of severe seizures in the methionine sulfoximine model of mesial temporal lobe epilepsy. ( Damisah, EC; Dhaher, R; Eid, T; Gruenbaum, BF; Gruenbaum, SE; Ong, C; Wang, H; Zaveri, HP, 2014) |
| " Because 5-aminovaleric acid (5-AV) has been implicated in modulation of the glutamine-glutamate-GABA metabolic pathway, we hypothesized that 5-AV would alter the expression of seizures in the MSO model of MTLE." | 3.80 | 5-aminovaleric acid suppresses the development of severe seizures in the methionine sulfoximine model of mesial temporal lobe epilepsy. ( Damisah, EC; Dhaher, R; Eid, T; Gruenbaum, BF; Gruenbaum, SE; Ong, C; Wang, H; Zaveri, HP, 2014) |
| "Pentobarbital and phenobarbital exhibited anticonvulsant effect against maximal electroshock (MES) and picrotoxin-induced seizures in rats." | 3.67 | Comparison of anticonvulsant effect of pentobarbital and phenobarbital against seizures induced by maximal electroshock and picrotoxin in rats. ( Mehta, AK; Ticku, MK, 1986) |
| "Both groups showed similar seizure frequency over days 3-21 (~1seizure/day)." | 1.40 | 5-aminovaleric acid suppresses the development of severe seizures in the methionine sulfoximine model of mesial temporal lobe epilepsy. ( Damisah, EC; Dhaher, R; Eid, T; Gruenbaum, BF; Gruenbaum, SE; Ong, C; Wang, H; Zaveri, HP, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (50.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dhaher, R | 1 |
| Damisah, EC | 1 |
| Wang, H | 1 |
| Gruenbaum, SE | 1 |
| Ong, C | 1 |
| Zaveri, HP | 1 |
| Gruenbaum, BF | 1 |
| Eid, T | 1 |
| Samuels, S | 1 |
| Fish, I | 1 |
| Schwartz, SA | 1 |
| Pertwee, RG | 1 |
| Browne, SE | 1 |
| Ross, TM | 1 |
| Stretton, CD | 1 |
| Mehta, AK | 1 |
| Ticku, MK | 1 |
4 other studies available for 5-aminovaleric acid and Seizures
| Article | Year |
|---|---|
5-aminovaleric acid suppresses the development of severe seizures in the methionine sulfoximine model of mesial temporal lobe epilepsy.
Topics: Amino Acids, Neutral; Animals; Brain; Disease Models, Animal; Epilepsy, Temporal Lobe; Male; Methion | 2014 |
Anticonvulsant activity of glycylglycine and delta-aminovaleric acid: evidence for glutamine exchange in amino acid transport.
Topics: Amino Acids; Amino Acids, Neutral; Animals; Anticonvulsants; Biological Transport; Brain; Dipeptides | 1983 |
An investigation of the involvement of GABA in certain pharmacological effects of delta-9-tetrahydrocannabinol.
Topics: Amino Acids; Amino Acids, Neutral; Analgesics; Animals; Anticonvulsants; Body Temperature; Cannabidi | 1991 |
Comparison of anticonvulsant effect of pentobarbital and phenobarbital against seizures induced by maximal electroshock and picrotoxin in rats.
Topics: Amino Acids; Amino Acids, Neutral; Animals; Anticonvulsants; Bicuculline; Electroshock; Male; Muscim | 1986 |