Compounds > 5-alpha-dihydroprogesterone
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5-alpha-dihydroprogesterone and Breast Cancer

5-alpha-dihydroprogesterone has been researched along with Breast Cancer in 8 studies

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (37.50)29.6817
2010's5 (62.50)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Elizalde, PV; Mercogliano, MF; Rivas, MA; Schillaci, R; Wiebe, JP1
Cadieux-Pitre, HA; Welch, I; Wiebe, JP; Zhang, G1
Kwok, A; Pawlak, KJ; Wiebe, JP1
Beausoleil, M; Cialacu, V; Wiebe, JP; Zhang, G1
Blair, IA; Byrns, MC; Duan, L; Lee, SH; Penning, TM1
Pawlak, KJ; Wiebe, JP; Zhang, G1
Weiler, PJ; Wiebe, JP1
Muzia, D; Wiebe, JP1

Other Studies

8 other study(ies) available for 5-alpha-dihydroprogesterone and Breast Cancer

ArticleYear
Progesterone-induced stimulation of mammary tumorigenesis is due to the progesterone metabolite, 5α-dihydroprogesterone (5αP) and can be suppressed by the 5α-reductase inhibitor, finasteride.
    The Journal of steroid biochemistry and molecular biology, 2015, Volume: 149

    Topics: 5-alpha Reductase Inhibitors; 5-alpha-Dihydroprogesterone; Animals; Breast; Breast Neoplasms; Carcinogenesis; Cell Line, Tumor; Cell Proliferation; Cholestenone 5 alpha-Reductase; Female; Finasteride; Humans; Mice; Mice, Inbred BALB C; Progesterone

2015
Progesterone metabolites regulate induction, growth, and suppression of estrogen- and progesterone receptor-negative human breast cell tumors.
    Breast cancer research : BCR, 2013, May-11, Volume: 15, Issue:3

    Topics: 20-alpha-Dihydroprogesterone; 5-alpha-Dihydroprogesterone; Animals; Antineoplastic Agents, Hormonal; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Female; Humans; Mice, Inbred NOD; Mice, SCID; Receptors, Estrogen; Receptors, Progesterone; Tissue Distribution; Tumor Burden; Xenograft Model Antitumor Assays

2013
Mechanism of action of the breast cancer-promoter hormone, 5α-dihydroprogesterone (5αP), involves plasma membrane-associated receptors and MAPK activation.
    The Journal of steroid biochemistry and molecular biology, 2016, Volume: 155, Issue:Pt A

    Topics: 5-alpha-Dihydroprogesterone; Binding Sites; Breast Neoplasms; Cell Line, Tumor; Cell Membrane; Cell Proliferation; Female; Humans; Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Receptors, Steroid

2016
Opposing actions of the progesterone metabolites, 5alpha-dihydroprogesterone (5alphaP) and 3alpha-dihydroprogesterone (3alphaHP) on mitosis, apoptosis, and expression of Bcl-2, Bax and p21 in human breast cell lines.
    The Journal of steroid biochemistry and molecular biology, 2010, Volume: 118, Issue:1-2

    Topics: 20-alpha-Dihydroprogesterone; 5-alpha-Dihydroprogesterone; Apoptosis; bcl-2-Associated X Protein; Breast Neoplasms; Cell Line; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p21; Female; Gene Expression Regulation, Neoplastic; Humans; Mammary Glands, Human; Mitosis; Progesterone; Proto-Oncogene Proteins c-bcl-2

2010
Aldo-keto reductase 1C3 expression in MCF-7 cells reveals roles in steroid hormone and prostaglandin metabolism that may explain its over-expression in breast cancer.
    The Journal of steroid biochemistry and molecular biology, 2010, Feb-15, Volume: 118, Issue:3

    Topics: 20-alpha-Dihydroprogesterone; 3-Hydroxysteroid Dehydrogenases; 5-alpha-Dihydroprogesterone; Aldo-Keto Reductase Family 1 Member C3; Androstenedione; Androsterone; Biocatalysis; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Dihydrotestosterone; Dinoprost; Estradiol; Estrone; Etiocholanolone; Female; Gene Expression Regulation, Neoplastic; Gonadal Steroid Hormones; Humans; Hydroxyprostaglandin Dehydrogenases; Ketosteroids; Kinetics; Progesterone; Prostaglandin D2; Prostaglandins; Recombinant Proteins; Testosterone; Transfection; Up-Regulation

2010
Membrane 5alpha-pregnane-3,20-dione (5alphaP) receptors in MCF-7 and MCF-10A breast cancer cells are up-regulated by estradiol and 5alphaP and down-regulated by the progesterone metabolites, 3alpha-dihydroprogesterone and 20alpha-dihydroprogesterone, with
    The Journal of steroid biochemistry and molecular biology, 2005, Volume: 97, Issue:3

    Topics: 20-alpha-Dihydroprogesterone; 5-alpha-Dihydroprogesterone; Antineoplastic Agents; Breast Neoplasms; Cell Adhesion; Cell Fractionation; Cell Line, Tumor; Cell Membrane; Cell Proliferation; Cycloheximide; Dactinomycin; Down-Regulation; Estradiol; Female; Humans; Progesterone; Receptors, Estradiol; Receptors, Progesterone; Up-Regulation

2005
Plasma membrane receptors for the cancer-regulating progesterone metabolites, 5alpha-pregnane-3,20-dione and 3alpha-hydroxy-4-pregnen-20-one in MCF-7 breast cancer cells.
    Biochemical and biophysical research communications, 2000, Jun-16, Volume: 272, Issue:3

    Topics: 20-alpha-Dihydroprogesterone; 5-alpha-Dihydroprogesterone; Binding Sites; Breast Neoplasms; Cell Fractionation; Cell Membrane; Cell Nucleus; Cytosol; Estradiol; Estrogen Antagonists; Female; Humans; Kinetics; Pregnanediones; Progesterone; Receptors, Cell Surface; Substrate Specificity; Thermodynamics; Tumor Cells, Cultured

2000
The endogenous progesterone metabolite, 5a-pregnane-3,20-dione, decreases cell-substrate attachment, adhesion plaques, vinculin expression, and polymerized F-actin in MCF-7 breast cancer cells.
    Endocrine, 2001, Volume: 16, Issue:1

    Topics: 5-alpha-Dihydroprogesterone; Actins; Adenocarcinoma; Breast Neoplasms; Cell Adhesion; Cytoskeleton; Female; Humans; Polymers; Pregnanediones; Tumor Cells, Cultured; Vinculin

2001