5-9-12-octadecatrienoic-acid has been researched along with Keratitis* in 2 studies
2 other study(ies) available for 5-9-12-octadecatrienoic-acid and Keratitis
| Article | Year |
|---|---|
Antagonists and inhibitors of lipid mediators in experimental inflammation of the cornea.
In experimental immunogenic keratitis, provoked in rabbits by intracorneal injection of 20 microliters of human serum albumin (HSA), various anti-inflammatory agents were studied in their effects on corneal edema, neovascularisation and leukocyte infiltration. Prophylactic treatment with a corticosteroid completely prevented the occurrence of keratitis. Nonsteroidal anti-inflammatory drugs such as a cyclooxygenase inhibitor partly prevented neovascularisation and corneal edema, a lipoxygenase inhibitor, a leukotriene antagonist or platelet-activating factor (PAF)-antagonist BN 52021 partially prevented mainly leukocyte infiltration. Prophylactic topical treatment with the poly-unsaturated fatty acids eicosapentaenoic acid and columbinic acid or a dietary supplement with fish oil showed less symptoms of keratitis in all respects. Topics: Animals; Chromones; Diterpenes; Eicosapentaenoic Acid; Fluorometholone; Ginkgolides; Keratitis; Lactones; Linolenic Acids; Lipids; Lipoxygenase Inhibitors; Male; Platelet Activating Factor; Rabbits; SRS-A; Suprofen | 1993 |
Modulation of immunogenic keratitis in rabbits by topical administration of poly-unsaturated fatty acids.
Several unsaturated fatty acids are precursors of prostaglandins and leukotrienes. Depending on their precursor, these prostaglandins and leukotrienes have different biological characteristics. The effects of topically administered fatty acids on an experimentally provoked inflammatory keratitis were studied in rabbits. Intrastromal injection with human serum albumin induced in the cornea a ring-shaped infiltration with leukocytes, corneal edema and neovascularization. Arachidonic, gamma-linolenic, dihomo-gamma-linolenic (DHGL), eicosapentaenoic (EPA) and columbinic acid were given as eye drops in a suspension in hydroxypropylmethylcellulose 0.5% three times daily during the experiment. EPA, DHGL, columbinic, and gamma-linolenic, but not arachidonic acid, showed a significant inhibition of either leukocyte infiltration, edema or neovascularization. The inhibitory effects of these fatty acids may be caused by topical inhibition of the formation of prostaglandins and leukotrienes in the arachidonic acid cascade in the rabbit cornea. Topics: Administration, Topical; Animals; Cornea; Eicosapentaenoic Acid; Fatty Acids; Fatty Acids, Unsaturated; Immune System Diseases; Keratitis; Linolenic Acids; Lipid Metabolism; Male; Rabbits | 1988 |