5,8,11,14-eicosatetraynoic acid has been researched along with Muscle Contraction in 43 studies
5,8,11,14-Eicosatetraynoic Acid: A 20-carbon unsaturated fatty acid containing 4 alkyne bonds. It inhibits the enzymatic conversion of arachidonic acid to prostaglandins E(2) and F(2a).
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The temporal relationship between release of the mediators histamine and slow reacting substance of anaphylaxis (SRS-A) and smooth muscle contraction in response to antigen was examined using superfused tracheae from actively sensitized (ovalbumin) and reserpine-pretreated guinea pigs." | 3.67 | Studies on the relationship between contraction and mediator release produced by ovalbumin in superfused trachea isolated from the actively sensitized guinea pig. ( Buckner, CK; Fishleder, RI, 1984) |
| " The pharmacologic characteristics of the antigen-induced airway smooth muscle contraction in vitro were similar to those induced by arachidonic acid and the leukotrienes only in some respects but were clearly different from those induced by compound 48/80." | 3.67 | Pharmacological characterization of airway smooth muscle responses to antigen in ascaris-sensitive dogs. ( Davis, C; Kannan, L; Kannan, MS; Ladenius, AR; Sankaranarayanan, A, 1986) |
| " Eicosatetraynoic acid (50 microM), nordihydroguairetic acid (50 microM) and QUIN (10 microM) do not exert significant inhibitory effects at the level of smooth muscle relaxation mechanisms as isoproterenol-induced relaxation was resistant to inhibition by these agents." | 3.66 | Endothelium-dependent relaxation of rabbit aorta. II. Inhibition of relaxation stimulated by methacholine and A23187 with antagonists of arachidonic acid metabolism. ( Peach, MJ; Singer, HA, 1983) |
| "Capsazepine was also observed to reverse cumulative responses to 20-HETE and capsaicin, a TRPV1 agonist." | 1.33 | Capsazepine, a vanilloid antagonist, abolishes tonic responses induced by 20-HETE on guinea pig airway smooth muscle. ( Cloutier, M; Morin, C; Proteau, S; Rousseau, E, 2005) |
| " Cumulative dose-response effects of ovalbumin were obtained on paired parenchymal strips, one used as control and the other drug treated." | 1.27 | Pharmacological alteration of antigen-induced contraction of lung parenchymal strips isolated from the actively sensitized guinea pig. ( Buckner, CK; Busse, WW; Songsiridej, V, 1983) |
| "Indomethacin pretreatment (14 microM, 30 min) potentiated the relaxation response in intact rings." | 1.27 | Endothelium-dependent relaxation of rabbit aorta. I. Relaxation stimulated by arachidonic acid. ( Peach, MJ; Singer, HA, 1983) |
| "Both indomethacin and ETYA were able to reverse the tachyphylaxis to angiotensin II." | 1.26 | Angiotensin analogs: effect of prostaglandin synthesis inhibitor. ( Gurchinoff, S; Hall, MM; Khairallah, PA; Khosla, MC, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 36 (83.72) | 18.7374 |
| 1990's | 4 (9.30) | 18.2507 |
| 2000's | 3 (6.98) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ratz, PH | 1 |
| Miner, AS | 1 |
| Barbour, SE | 1 |
| Rousseau, E | 1 |
| Cloutier, M | 1 |
| Morin, C | 1 |
| Proteau, S | 1 |
| Falkenhein, SF | 2 |
| MacDonald, H | 1 |
| Huber, MM | 2 |
| Koch, D | 1 |
| Parker, CW | 2 |
| Regal, JF | 2 |
| Songsiridej, V | 1 |
| Busse, WW | 1 |
| Buckner, CK | 2 |
| Miller, RC | 1 |
| Mony, M | 1 |
| Schini, V | 1 |
| Schoeffter, P | 1 |
| Stoclet, JC | 1 |
| Fishleder, RI | 1 |
| Spies, C | 1 |
| Schultz, KD | 1 |
| Schultz, G | 1 |
| Mitchell, HW | 3 |
| Singer, HA | 2 |
| Peach, MJ | 2 |
| Stimler, NP | 1 |
| O'Flaherty, JT | 1 |
| Pickering, RJ | 1 |
| Craib, SJ | 1 |
| Ellington, HC | 1 |
| Pertwee, RG | 1 |
| Ross, RA | 1 |
| Hoffman, MK | 1 |
| Caschetto, S | 1 |
| Lindblom, B | 2 |
| Wiqvist, N | 1 |
| Wilhelmsson, L | 1 |
| Daniel, EE | 2 |
| Crankshaw, J | 1 |
| Sarna, S | 1 |
| Hall, MM | 1 |
| Gurchinoff, S | 1 |
| Khosla, MC | 1 |
| Khairallah, PA | 1 |
| Greenberg, S | 1 |
| Altura, BM | 1 |
| Altura, BT | 1 |
| Tuvemo, T | 2 |
| Strandberg, K | 2 |
| Hamberg, M | 1 |
| Samuelsson, B | 1 |
| Diekmann, JM | 1 |
| Jobke, A | 2 |
| Peskar, BA | 2 |
| Hertting, G | 2 |
| Coceani, F | 1 |
| Olley, PM | 1 |
| Bishai, I | 1 |
| Bodach, E | 1 |
| Heaton, J | 1 |
| Nashat, M | 1 |
| White, E | 1 |
| Yamaguchi, T | 2 |
| Hitzig, B | 2 |
| Coburn, RF | 2 |
| Kalsner, S | 1 |
| Orehek, J | 1 |
| Douglas, JS | 1 |
| Bouhuys, A | 1 |
| Yoshida, M | 1 |
| Koeda, T | 1 |
| Sánchez-Ferrer, CF | 1 |
| Fernández-Alfonso, MS | 1 |
| Ponte, A | 1 |
| Casado, MA | 1 |
| González, R | 1 |
| Rodríguez-Mañas, L | 1 |
| Pareja, A | 1 |
| Marín, J | 1 |
| Yamamoto, A | 1 |
| Shikada, K | 1 |
| Tanaka, S | 1 |
| Gill, KK | 1 |
| Kroeger, EA | 1 |
| Thomas, G | 1 |
| Ramwell, P | 1 |
| Hand, JM | 2 |
| Schwalm, SF | 2 |
| Lewis, AJ | 2 |
| Kannan, MS | 1 |
| Davis, C | 1 |
| Sankaranarayanan, A | 1 |
| Ladenius, AR | 1 |
| Kannan, L | 1 |
| Hageman, WE | 1 |
| Rose, MP | 1 |
| Persico, FJ | 1 |
| Fox, JE | 1 |
| Kostolanska, F | 1 |
| Allescher, HD | 1 |
| Hanke, T | 1 |
| Andersson, A | 1 |
| Greenberg, R | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Liberal Versus Restrictive Platelet Transfusion for Treatment of Hemodynamically Significant Patent Ductus Arteriosus in Thrombocytopenic Preterm Neonates- A Randomized Open Label, Controlled Trial[NCT03022253] | Phase 3 | 44 participants (Anticipated) | Interventional | 2016-03-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for 5,8,11,14-eicosatetraynoic acid and Muscle Contraction
| Article | Year |
|---|---|
Vascular smooth muscle and prostaglandins.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Angiotensin II; Animals; Aorta; Aspirin; Epinephrine; Indomethacin; | 1976 |
42 other studies available for 5,8,11,14-eicosatetraynoic acid and Muscle Contraction
| Article | Year |
|---|---|
Calcium-independent phospholipase A2 participates in KCl-induced calcium sensitization of vascular smooth muscle.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Arachidonic Acid; Calcium; Kinetics; Muscle Contraction; M | 2009 |
Capsazepine, a vanilloid antagonist, abolishes tonic responses induced by 20-HETE on guinea pig airway smooth muscle.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Bronchi; Calcium; Calcium Channels; Capsaicin; Cyclohexano | 2005 |
Effect of the 5-hydroperoxide of eicosatetraenoic acid and inhibitors of the lipoxygenase pathway on the formation of slow reacting substance by rat basophilic leukemia cells; direct evidence that slow reacting substance is a product of the lipoxygenase p
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; 5,8,11,14-Eicosatetraynoic Acid; Animals; Arachidonic Ac | 1980 |
C5a-induced aortic contraction: effect of an antihistamine and inhibitors of arachidonate metabolism.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Aorta, Thoracic; Arachidonic Acid; Arachidonic Acids; Aspi | 1982 |
Pharmacological alteration of antigen-induced contraction of lung parenchymal strips isolated from the actively sensitized guinea pig.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Antigens; Drug Interactions; Female; Guinea Pigs; Histamin | 1983 |
Endothelial mediated inhibition of contraction and increase in cyclic GMP levels evoked by the alpha-adrenoceptor agonist B-HT 920 in rat isolated aorta.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Adrenergic alpha-Agonists; Animals; Aorta; Azepines; Cyclic AMP; Cy | 1984 |
Studies on the relationship between contraction and mediator release produced by ovalbumin in superfused trachea isolated from the actively sensitized guinea pig.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Carbachol; Chromones; Dose-Response Relationship, Drug; Fe | 1984 |
Inhibitory effects of mepacrine and eicosatetraynoic acid on cyclic GMP elevations caused by calcium and hormonal factors in rat ductus deferens.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Calcium; Cyclic GMP; Fatty Acids; Fatty Acids, Unsaturated | 1980 |
The lipoxygenase pathway and tracheal muscle contraction.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; 5,8,11,14-Eicosatetraynoic Acid; Anima | 1983 |
Endothelium-dependent relaxation of rabbit aorta. I. Relaxation stimulated by arachidonic acid.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Aorta, Thoracic; Arachidonic Acid; Arachidonic Acids; Cate | 1983 |
Endothelium-dependent relaxation of rabbit aorta. II. Inhibition of relaxation stimulated by methacholine and A23187 with antagonists of arachidonic acid metabolism.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Anti-Bacterial Agents; Aorta, Thoracic; Arachidonic Acid; | 1983 |
Spasmogenic properties of platelet-activating factor: evidence for a direct mechanism in the contractile response of pulmonary tissues.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Aspirin; Blood Platelets; Catechols; Chromones; Dose-Respo | 1983 |
The effect of inhibitors of arachidonic acid metabolism on drug-induced contractions in isolated tracheal smooth muscle of the pig.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Acetylcholine; Animals; Arachidonic Acid; Arachidonic Acids; Dexame | 1982 |
Effect of ETYA and BW 755c on arachidonate-induced contractions in the guinea-pig isolated trachea.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; 5,8,11,14-Eicosatetraynoic Acid; Airwa | 1982 |
C5a-induced tracheal contraction: effect of an SRS-A antagonist and inhibitors of arachidonate metabolism.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Arachidonic Acids; Complement C5; Guinea Pigs; Muscle Cont | 1981 |
A possible role of lipoxygenase in the activation of vanilloid receptors by anandamide in the guinea-pig bronchus.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Arachidonic Acids; Bronchi; Calcium Channel Blockers; Caps | 2001 |
Characterization of the two major species of slow reacting substance from rat basophilic leukemia cells as glutathionyl thioethers of eicosatetraenoic acids oxygenated at the 5 position. Evidence that peroxy groups are present and important for spasmogeni
Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Autacoids; Basophils; Chemical Phenomena; Chemistry; Fatty | 1979 |
Prostaglandins and the contractile function of the human oviductal ampulla.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Adult; Cyclooxygenase Inhibitors; Epoprostenol; Ethanol; Fallopian | 1979 |
Prostaglandins and tetrodotoxin-insensitive relaxation of opossum lower esophageal sphincter.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Action Potentials; Animals; Black Widow Spider; Carbachol; Esophago | 1979 |
Angiotensin analogs: effect of prostaglandin synthesis inhibitor.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Angiotensin II; Animals; Aorta, Thoracic; Arteries; Dose-Response R | 1978 |
Evidence for enhanced venous smooth muscle turnover of prostaglandin-like substance in portal veins from spontaneously hypertensive rats.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Angiotensin II; Animals; Arachidonic Acids; Drug Interactions; Hype | 1976 |
Maintenance of the tone of the human umbilical artery by prostaglandin and thromboxane formation.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Humans | 1976 |
Angiotensin II-induced contractions of rabbit splenic capsular strips and release of prostaglandins. Use of radioimmunoassays for prostaglandins E1 and E2.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Angiotensin II; Animals; Drug Interactions; Female; Indomethacin; M | 1977 |
Prostaglandins and the control of muscle tone in the ductus arteriosus.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Arachidonic Acids; Ductus Arteriosus; Gestational Age; Glu | 1977 |
On the relation between release of prostaglandins and contractility of rabbit splenic capsular strips.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Cocaine; Female; In Vitro Techniques; Indomethacin; Male; | 1976 |
Endogenous prostaglandins and mechanical tension in canine trachealis muscle.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Aspirin; Atropine; Carbachol; Dogs; Indomethacin; Membrane | 1976 |
Intrinsic prostaglandin release. A mediator of anoxia-induced relaxation in an isolated coronary artery preparation.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Arteries; Aspirin; Cattle; Coronary Vessels; Hypoxia; Indo | 1976 |
Contractile responses of the guinea-pig trachea in vitro: modification by prostaglandin synthesis-inhibiting drugs.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Acetylcholine; Animals; Anti-Inflammatory Agents; Aspirin; Barium; | 1975 |
Reduction of the tone of the isolated human umbilical artery by indomethacin, eicosa-5,8,11,14-tetraynoic acid and polyphloretin phosphate.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Depression, Chemical; Dose-Response Relationship, Drug; Drug Intera | 1975 |
Endogenous prostaglandin in guinea pig taenia coli.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Action Potentials; Animals; Aspirin; Atropine; Carbachol; Colon; Do | 1976 |
Studies on the electrical stimulation-induced contractile responses of hamster and mouse gallbladders.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Atropine; Cricetinae; Electric Stimulation; Ethanol; Gallb | 1992 |
Endothelial modulation of the ouabain-induced contraction in human placental vessels.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Adult; Arginine; Arteries; Biological Assay; Blood Vessels; Endothe | 1992 |
Arachidonate lipoxygenase inhibitors in guinea-pig isolated trachea. Effects on contractions to antigen and various agonists.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Antigens; Arachidonate Lipoxygenases; Calcimycin; Chromone | 1990 |
Effects of indomethacin on neural and myogenic components in equine airway smooth muscle.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Acetylcholine; Animals; Atropine; Dinoprostone; Horses; In Vitro Te | 1990 |
Induction of vascular relaxation by hydroperoxides.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Arachidonic Acids; Chlorobenzoates; Endothelium; Hydroxide | 1986 |
Antagonism of antigen-induced contraction of isolated guinea-pig trachea by 5-lipoxygenase inhibitors.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; 5,8,11,14-Eicosatetraynoic Acid; Anima | 1986 |
Pharmacological characterization of airway smooth muscle responses to antigen in ascaris-sensitive dogs.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Acetylcholine; Airway Resistance; Animals; Antigens, Helminth; Arac | 1986 |
Antagonism by ETYA of the effects of leukotrienes on ileum and lung parenchymal strips independent of effects on arachidonic acid metabolism.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Arachidonic Acid; Arachidonic Acids; Chromones; Fatty Acid | 1986 |
Inhibition of leukotriene-induced contraction of guinea pig trachea by 5-lipoxygenase inhibitors.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; 5,8,11,14-Eicosatetraynoic Acid; Anima | 1987 |
Mechanisms of excitatory actions of neurotensin on canine small intestinal circular muscle in vivo and in vitro.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Acetylcholine; Animals; Dogs; Drug Interactions; Egtazic Acid; Fema | 1987 |
Influence of cyclooxygenase inhibitors and arachidonic acid on contractile activity of the human Fallopian tube.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Adult; Arachidonic Acid; Arachidonic Acids; Cyclooxygenase Inhibito | 1985 |
The effects of indomethacin and eicosa-5,8,11,14-tetraynoic acid on the response of the rabbit portal vein to electrical stimulation.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Electric Stimulation; Fatty Acids, Unsaturated; Guanethidi | 1974 |