5,8,11,14-eicosatetraynoic acid has been researched along with Leukemia, Myelogenous, Chronic, BCR-ABL Positive in 3 studies
5,8,11,14-Eicosatetraynoic Acid: A 20-carbon unsaturated fatty acid containing 4 alkyne bonds. It inhibits the enzymatic conversion of arachidonic acid to prostaglandins E(2) and F(2a).
Leukemia, Myelogenous, Chronic, BCR-ABL Positive: Clonal hematopoetic disorder caused by an acquired genetic defect in PLURIPOTENT STEM CELLS. It starts in MYELOID CELLS of the bone marrow, invades the blood and then other organs. The condition progresses from a stable, more indolent, chronic phase (LEUKEMIA, MYELOID, CHRONIC PHASE) lasting up to 7 years, to an advanced phase composed of an accelerated phase (LEUKEMIA, MYELOID, ACCELERATED PHASE) and BLAST CRISIS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The hallmark of chronic myeloid leukemia (CML) is the presence of the bcr-abl oncogene, which is associated with transforming ability and an intrinsic resistance to induction of apoptosis by genotoxic agents." | 1.30 | Induction of apoptosis by arachidonic acid in chronic myeloid leukemia cells. ( Akard, L; Boswell, HS; Carlo-Stella, C; Dugan, M; Garau, D; Regazzi, E; Rizzo, MT; Rizzoli, V, 1999) |
| "We cultured chronic myelogenous leukemia cells from the peripheral blood of several patients in blast crisis with three inhibitors of lipoxygenases: ETYA, and the more selective A63162 (Abbott) or SC41661A (Searle)." | 1.29 | Induction of apoptosis in blood cells from a patient with acute myelogenous leukemia by SC41661A, a selective inhibitor of 5-lipoxygenase. ( Anderson, KM; Harris, JE; Jajeh, A; Levin, J; Seed, T, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Anderson, KM | 2 |
| Levin, J | 1 |
| Jajeh, A | 2 |
| Seed, T | 2 |
| Harris, JE | 2 |
| Plate, JM | 1 |
| Meng, J | 1 |
| Rizzo, MT | 1 |
| Regazzi, E | 1 |
| Garau, D | 1 |
| Akard, L | 1 |
| Dugan, M | 1 |
| Boswell, HS | 1 |
| Rizzoli, V | 1 |
| Carlo-Stella, C | 1 |
3 other studies available for 5,8,11,14-eicosatetraynoic acid and Leukemia, Myelogenous, Chronic, BCR-ABL Positive
| Article | Year |
|---|---|
Induction of apoptosis in blood cells from a patient with acute myelogenous leukemia by SC41661A, a selective inhibitor of 5-lipoxygenase.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Acetamides; Amides; Apoptosis; Base Sequence; Blast Crisis; Blood C | 1993 |
Selective inhibitors of 5-lipoxygenase reduce CML blast cell proliferation and induce limited differentiation and apoptosis.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Acetamides; Amides; Antineoplastic Agents; Apoptosis; Blast Crisis; | 1995 |
Induction of apoptosis by arachidonic acid in chronic myeloid leukemia cells.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Adult; Animals; Antioxidants; Apoptosis; Arachidonic Acid; Bone Mar | 1999 |