5,8,11,14-eicosatetraynoic acid has been researched along with Glioma in 2 studies
5,8,11,14-Eicosatetraynoic Acid: A 20-carbon unsaturated fatty acid containing 4 alkyne bonds. It inhibits the enzymatic conversion of arachidonic acid to prostaglandins E(2) and F(2a).
Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
| Excerpt | Relevance | Reference |
|---|---|---|
| "When cultured malignant cells derived from rat gliomas (C6 and 9L) and human gliomas (A-172 and T98G) were treated for 4 hours with 1 to 80 microns nordihydroguaiaretic acid (NDGA) or 5,8,11,14-eicosatetraynoic acid (ETYA), a dose-dependent inhibition of deoxyribonucleic acid (DNA) synthesis occurred." | 3.67 | Effect of nordihydroguaiaretic acid on cultured rat and human glioma cell proliferation. ( Anderson, KM; DiGianfilippo, A; Harris, JE; Ondrey, FG; Wilson, DE, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wilson, DE | 2 |
| Anderson, KM | 2 |
| Seed, TM | 1 |
| DiGianfilippo, A | 1 |
| Ondrey, FG | 1 |
| Harris, JE | 1 |
2 other studies available for 5,8,11,14-eicosatetraynoic acid and Glioma
| Article | Year |
|---|---|
Ultrastructural evidence for differentiation in a human glioblastoma cell line treated with inhibitors of eicosanoid metabolism.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Cell Differentiation; Eicosanoids; Glial Fibrillary Acidic Protein; | 1990 |
Effect of nordihydroguaiaretic acid on cultured rat and human glioma cell proliferation.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Aspirin; Catechols; Cell Division; Cell Line; Cell Surviva | 1989 |