Compounds > 5-7-dihydroxy-6-methoxy-2-phenylchromen-4-one

5-7-dihydroxy-6-methoxy-2-phenylchromen-4-one and Edema

5-7-dihydroxy-6-methoxy-2-phenylchromen-4-one has been researched along with Edema* in 1 studies

Other Studies

1 other study(ies) available for 5-7-dihydroxy-6-methoxy-2-phenylchromen-4-one and Edema

Article	Year
Antioxidative and anti-inflammatory activities of polyhydroxyflavonoids of Scutellaria baicalensis GEORGI. Bioscience, biotechnology, and biochemistry, 2006, Volume: 70, Issue:10 The active ingredients of 'golden root' of Scutellaria baicalensis GEORGI (Huang-Qin), a valuable traditional Chinese medicine, are polyhydroxyflavonoids, namely baicalein, oroxylin A and wogonin. With the objective of overcoming their poor solubility and to investigate their structure and activity relationships, baicaleinyl 7-O-sulfate was prepared, and extensive comparative antioxidative and anti-inflammatory tests were conducted. All the polyhydroxyflavonoids exhibited significant antioxidative and free-radical scavenging activities. In respect of their nitric oxide (NO) inhibition, wogonin was superior to all the other flavonoids, while oroxylin A was most potent in the inhibition of lipid peroxidation. Wogonin proved to be the most potent (82.9% inhibition, p<0.05) in its anti-inflammatory activity against carrageenan-induced rat hind paw edema. There was a correlation between the in-vivo anti-inflammatory activity and the in-vitro antioxidative activities. Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Drugs, Chinese Herbal; Edema; Flavanones; Flavonoids; Free Radical Scavengers; Lipid Peroxidation; Nitric Oxide; Phytotherapy; Rats; Scutellaria baicalensis; Solubility; Structure-Activity Relationship	2006

Article

Year

Antioxidative and anti-inflammatory activities of polyhydroxyflavonoids of Scutellaria baicalensis GEORGI.

Bioscience, biotechnology, and biochemistry, 2006, Volume: 70, Issue:10

The active ingredients of 'golden root' of Scutellaria baicalensis GEORGI (Huang-Qin), a valuable traditional Chinese medicine, are polyhydroxyflavonoids, namely baicalein, oroxylin A and wogonin. With the objective of overcoming their poor solubility and to investigate their structure and activity relationships, baicaleinyl 7-O-sulfate was prepared, and extensive comparative antioxidative and anti-inflammatory tests were conducted. All the polyhydroxyflavonoids exhibited significant antioxidative and free-radical scavenging activities. In respect of their nitric oxide (NO) inhibition, wogonin was superior to all the other flavonoids, while oroxylin A was most potent in the inhibition of lipid peroxidation. Wogonin proved to be the most potent (82.9% inhibition, p<0.05) in its anti-inflammatory activity against carrageenan-induced rat hind paw edema. There was a correlation between the in-vivo anti-inflammatory activity and the in-vitro antioxidative activities.

Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Drugs, Chinese Herbal; Edema; Flavanones; Flavonoids; Free Radical Scavengers; Lipid Peroxidation; Nitric Oxide; Phytotherapy; Rats; Scutellaria baicalensis; Solubility; Structure-Activity Relationship

2006