5-7-dihydroxy-6-methoxy-2-phenylchromen-4-one and Asthma

Oroxylin A, a natural flavonoid isolated from the medicinal herb Scutellaria baicalensis Georgi, has been reported to have anti-inflammatory property. In this study, we aimed to investigate the protective effects and mechanism of oroxylin A on allergic inflammation in OVA-induced asthma murine model. BABL/c mice were sensitized and airway-challenged with OVA to induce asthma. Oroxylin A (15, 30, and 60 mg/kg) was administered by oral gavage 1 h before the OVA treatment on day 21 to 23. The results showed that oroxylin A attenuated OVA-induced lung histopathologic changes, airway hyperresponsiveness, and the number of inflammatory cells. Oroxylin A also inhibited the levels of IL-4, IL-5, IL-13, and OVA-specific IgE in BALF. Furthermore, oroxylin A significantly inhibited OVA-induced NF-κB activation. In conclusion, these results suggested that oroxylin A inhibited airway inflammation in OVA-induced asthma murine model by inhibiting NF-κB activation. These results suggested that oroxylin A was a potential therapeutic drug for treating allergic asthma.

Topics: Animals; Anti-Inflammatory Agents; Asthma; Disease Models, Animal; Enzyme Activation; Female; Flavonoids; Immunoglobulin E; Inflammation; Interleukin-13; Interleukin-4; Interleukin-5; Mice; Mice, Inbred BALB C; NF-kappa B; Ovalbumin; Plant Preparations; Scutellaria baicalensis