5-7-dihydroxy-4--6-dimethoxyflavone has been researched along with Neoplasm-Metastasis* in 1 studies
1 other study(ies) available for 5-7-dihydroxy-4--6-dimethoxyflavone and Neoplasm-Metastasis
| Article | Year |
|---|---|
Natural product pectolinarigenin exhibits potent anti-metastatic activity in colorectal carcinoma cells in vitro and in vivo.
Colorectal carcinoma (CRC) is one of the most common cancers with high metastatic potential, explaining why identifying new drug candidates that inhibit tumour metastasis is an urgent need. The aim of this study was to evaluate the biological activities of pectolinarigenin (PEC, a natural flavonoid present in Cirsium chanroenicum) in CRC in vitro and in vivo and to determine its underlying mechanism of action. Here, we observed that treatment with PEC could inhibit cell viability and induce apoptosis in cancer cells in a concentration- and time-dependent manner. The occurrence of apoptosis was associated with activation of caspase-3 and Bax and decreased expression of Bcl-2. In addition, PEC markedly impaired CRC cell migration and invasion by downregulating the expression of matrix metalloproteinase (MMP-9) and phosphorylated-Stat3 Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chromones; Colorectal Neoplasms; Down-Regulation; Female; Matrix Metalloproteinase 9; Mice, Inbred BALB C; Myeloid-Derived Suppressor Cells; Neoplasm Metastasis; STAT3 Transcription Factor | 2019 |