5,7-dichlorokynurenic acid has been researched along with Nerve Degeneration in 3 studies
5,7-dichlorokynurenic acid: potent antagonist at the N-methyl-D-aspartate receptor-associated glycine binding site
Nerve Degeneration: Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Memantine, an N-methyl-D-aspartate (NMDA) receptor antagonist, reduces the clinical deterioration in moderate-to-severe Alzheimer disease (AD) for which other treatments are not available." | 3.72 | Memantine inhibits and reverses the Alzheimer type abnormal hyperphosphorylation of tau and associated neurodegeneration. ( Grundke-Iqbal, I; Haque, N; Iqbal, K; Li, L; Sengupta, A, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Li, L | 1 |
| Sengupta, A | 1 |
| Haque, N | 1 |
| Grundke-Iqbal, I | 1 |
| Iqbal, K | 1 |
| Wu, SZ | 1 |
| Jiang, S | 1 |
| Sims, TJ | 1 |
| Barger, SW | 1 |
| Boireau, A | 1 |
| Malgouris, C | 1 |
| Burgevin, MC | 1 |
| Pény, C | 1 |
| Durand, G | 1 |
| Bordier, F | 1 |
| Meunier, M | 1 |
| Miquet, JM | 1 |
| Daniel, M | 1 |
| Chevet, T | 1 |
| Jimonet, P | 1 |
| Mignani, S | 1 |
| Blanchard, JC | 1 |
| Doble, A | 1 |
3 other studies available for 5,7-dichlorokynurenic acid and Nerve Degeneration
| Article | Year |
|---|---|
Memantine inhibits and reverses the Alzheimer type abnormal hyperphosphorylation of tau and associated neurodegeneration.
Topics: 2-Amino-5-phosphonovalerate; Alzheimer Disease; Animals; Calcium-Calmodulin-Dependent Protein Kinase | 2004 |
Schwann cells exhibit excitotoxicity consistent with release of NMDA receptor agonists.
Topics: 2-Amino-5-phosphonovalerate; Analysis of Variance; Animals; Calcium; Cell Death; Cells, Cultured; Cu | 2005 |
Neuroprotective effects of RPR 104632, a novel antagonist at the glycine site of the NMDA receptor, in vitro.
Topics: Aminoquinolines; Animals; Benzothiadiazines; Binding, Competitive; Cerebral Cortex; Cyclic GMP; Exci | 1996 |