5-6-diphenyl-1-2-4-triazine-3-thiol has been researched along with Edema* in 1 studies
1 other study(ies) available for 5-6-diphenyl-1-2-4-triazine-3-thiol and Edema
| Article | Year |
|---|---|
Novel 5,6-diphenyl-1,2,4-triazine-3-thiol derivatives as dual COX-2/5-LOX inhibitors devoid of cardiotoxicity.
A novel series of 5,6-diphenyl-1,2,4-triazine-3-thiol derivatives were designed, synthesized, and screened for their inhibitory potential against COX-2 and 5-LOX enzymes. The compounds from the series have shown moderate to excellent inhibitory potential against both targets. Compound 6k showed the inhibitions against COX-2 (IC Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 5-Lipoxygenase; Cardiotoxicity; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Edema; Lipoxygenase Inhibitors; Molecular Docking Simulation; Molecular Structure; Rats; Structure-Activity Relationship; Sulfhydryl Compounds | 2022 |