5-6-7-trimethoxyflavone has been researched along with Neoplasms* in 2 studies
2 other study(ies) available for 5-6-7-trimethoxyflavone and Neoplasms
| Article | Year |
|---|---|
Synthesis and anti-proliferative activities of 5,6,7-trimethoxyflavones and their derivatives.
A series of 5,6,7-trimethoxyflavones Topics: Antineoplastic Agents; Cell Line, Tumor; Flavones; Flavonoids; Humans; Neoplasms; Structure-Activity Relationship | 2022 |
Synthesis of novel flavone derivatives possessing substituted benzamides and their biological evaluation against human cancer cells.
Baicalein is a well-known flavone derivative that possesses diverse biological properties, such as anticancer, antioxidant and anti-inflammatory activities. Numerous baicalein derivatives, including 5,6,7-trimethoxyflavone, have been synthesized with the aim of enhancing its inherent biological activities. In the present work, new flavones, possessing an N-aroylamine-substituent on the B-ring, were synthesized to improve the cytotoxicity of baicalein and 5,6,7-trimethoxyflavone against human cancer cell lines. The majority of the flavones synthesized exhibited greater cytotoxicity than baicalein and 5,6,7-trimethoxyflavone against HepG2 and MCF-7 cells. Among them, compounds 5n, possessing a 3-methoxybenzoylamino group, exhibited great cytotoxic effects on HepG2 (GI50=7.06μM) and MCF-7 (GI50=7.67μM) cells. In contrast, N-aroylamine-substituted 5-hydroxy-6,7-dimethoxyflavone derivatives showed greater cytotoxicity against MCF-7 than HepG2 cells, indicating that the replacement of a 5-methoxy group on the A-ring with a 5-hydroxy group has a marked influence on the cytotoxicity profile. Topics: Antineoplastic Agents; Benzamides; Cell Survival; Flavanones; Flavones; Flavonoids; Hep G2 Cells; Humans; MCF-7 Cells; Neoplasms; Structure-Activity Relationship | 2016 |