5,5-dimethyl-1-pyrroline-1-oxide has been researched along with Neuroblastoma in 3 studies
5,5-dimethyl-1-pyrroline-1-oxide: do not confuse with DMPO (4',5'-dihydroxy-7-methoxy-4-phenyl-5,2'-oxidocoumarin)
5,5-dimethyl-1-pyrroline N-oxide : A member of the class of 1-pyrroline nitrones (1-pyrroline N-oxides) resulting from the formal N-oxidation of 5,5-dimethyl-1-pyrroline. Used as a spin trap for the study of radicals formed by enzymatic acetaldehyde oxidation.
Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The underlying cause of Alzheimer's disease is thought to be the aggregation of monomeric beta-amyloid (Abeta), through a series of toxic oligomers, which forms the mature amyloid fibrils that accumulate at the center of senile plaques." | 1.32 | Both the D-(+) and L-(-) enantiomers of nicotine inhibit Abeta aggregation and cytotoxicity. ( Allsop, D; El-Agnaf, OM; Fullwood, NJ; Gibson, GL; Huckerby, TN; Moore, SA; Tabner, BJ; Turnbull, S, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Aquilano, K | 1 |
| Rotilio, G | 1 |
| Ciriolo, MR | 1 |
| Moore, SA | 1 |
| Huckerby, TN | 1 |
| Gibson, GL | 1 |
| Fullwood, NJ | 1 |
| Turnbull, S | 1 |
| Tabner, BJ | 1 |
| El-Agnaf, OM | 1 |
| Allsop, D | 1 |
| Kwak, HS | 1 |
| Yim, HS | 1 |
| Chock, PB | 1 |
| Yim, MB | 1 |
3 other studies available for 5,5-dimethyl-1-pyrroline-1-oxide and Neuroblastoma
| Article | Year |
|---|---|
Proteasome activation and nNOS down-regulation in neuroblastoma cells expressing a Cu,Zn superoxide dismutase mutant involved in familial ALS.
Topics: Amyotrophic Lateral Sclerosis; Cell Survival; Cyclic N-Oxides; Cysteine Endopeptidases; Down-Regulat | 2003 |
Both the D-(+) and L-(-) enantiomers of nicotine inhibit Abeta aggregation and cytotoxicity.
Topics: Amyloid beta-Peptides; Cell Line, Tumor; Cyclic N-Oxides; Electron Spin Resonance Spectroscopy; Grow | 2004 |
Endogenous intracellular glutathionyl radicals are generated in neuroblastoma cells under hydrogen peroxide oxidative stress.
Topics: Acetylcysteine; Cell Line; Cyclic N-Oxides; Electron Spin Resonance Spectroscopy; Free Radicals; Glu | 1995 |