Compounds > 5-5--6-6--tetrachloro-1-1--3-3--tetraethylbenzimidazolocarbocyanine

5-5--6-6--tetrachloro-1-1--3-3--tetraethylbenzimidazolocarbocyanine and Lung-Neoplasms

5-5--6-6--tetrachloro-1-1--3-3--tetraethylbenzimidazolocarbocyanine has been researched along with Lung-Neoplasms* in 2 studies

Other Studies

2 other study(ies) available for 5-5--6-6--tetrachloro-1-1--3-3--tetraethylbenzimidazolocarbocyanine and Lung-Neoplasms

Article	Year
Synthesis, characterization, in vitro SAR and in vivo evaluation of N,N'bisnaphthylmethyl 2-alkyl substituted imidazolium salts against NSCLC. Bioorganic & medicinal chemistry letters, 2017, 02-15, Volume: 27, Issue:4 Topics: A549 Cells; Animals; Antineoplastic Agents; Benzimidazoles; Carbocyanines; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Survival; Drug Screening Assays, Antitumor; Humans; Imidazoles; Kaplan-Meier Estimate; Lung Neoplasms; Membrane Potential, Mitochondrial; Mice; Mice, Inbred C57BL; Microscopy, Fluorescence; Mitochondria; Molecular Conformation; Naphthols; Salts; Structure-Activity Relationship; Transplantation, Heterologous	2017
Oestrogen-related receptor alpha inverse agonist XCT-790 arrests A549 lung cancer cell population growth by inducing mitochondrial reactive oxygen species production. Cell proliferation, 2010, Volume: 43, Issue:2 Although oestrogen-related receptor alpha (ERRalpha) is primarily thought to regulate energy homeostasis, it also serves as a prognostic marker for cancer. The aim of this study was to investigate any connection between ERRalpha activity and cell population growth.. XCT-790, an ERRa specific inverse agonist, was employed to suppress ERRa activity in human non-small cell lung cancer cells (NSCLC) A549. Gene expressions were detected using quantitative real-time PCR and Western blot analysis. Mitochondrial mass, membrane potential and reactive oxygen species (ROS) production were measured by staining with Mitotracker green, JC-1 and CM-H(2)DCFDA dyes respectively. Rate of progression through the tricarboxylic acid (TCA) cycle was analysed by measuring activities of citrate synthase and succinate dehydrogenase. Cell cycle analysis was performed by using flow cytometry.. We found that XCT-790 treatment reduced mitochondrial mass but enhanced mitochondrial ROS production by increasing rate through the TCA cycle, elevating mitochondrial membrane potential (DeltaPsi(m)) and down-regulating expression of superoxide dismutase. It was further demonstrated that XCT-790-induced ROS modulated p53 and Rb signalling pathways and suppressed cell replication.. ERRalpha affects cell cycle mechanisms through modulating mitochondrial mass and function. Dysregulation of this essential pathway leads to elevation in mitochondrial ROS production, which in turn modulates activities of tumour suppressors, resulting in cell cycle arrest. Topics: Benzimidazoles; Carbocyanines; Carcinoma, Non-Small-Cell Lung; Cell Cycle; Cell Line, Tumor; Dose-Response Relationship, Drug; ERRalpha Estrogen-Related Receptor; Fluorescent Dyes; Humans; Lung; Lung Neoplasms; Membrane Potential, Mitochondrial; Membrane Potentials; Mitochondria; Nitriles; Reactive Oxygen Species; Receptors, Estrogen; Signal Transduction; Superoxide Dismutase; Thiazoles; Time Factors; Tumor Suppressor Protein p53	2010

Article

Year

Synthesis, characterization, in vitro SAR and in vivo evaluation of N,N'bisnaphthylmethyl 2-alkyl substituted imidazolium salts against NSCLC.

Bioorganic & medicinal chemistry letters, 2017, 02-15, Volume: 27, Issue:4

Topics: A549 Cells; Animals; Antineoplastic Agents; Benzimidazoles; Carbocyanines; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Survival; Drug Screening Assays, Antitumor; Humans; Imidazoles; Kaplan-Meier Estimate; Lung Neoplasms; Membrane Potential, Mitochondrial; Mice; Mice, Inbred C57BL; Microscopy, Fluorescence; Mitochondria; Molecular Conformation; Naphthols; Salts; Structure-Activity Relationship; Transplantation, Heterologous

2017

Cell proliferation, 2010, Volume: 43, Issue:2

Although oestrogen-related receptor alpha (ERRalpha) is primarily thought to regulate energy homeostasis, it also serves as a prognostic marker for cancer. The aim of this study was to investigate any connection between ERRalpha activity and cell population growth.. XCT-790, an ERRa specific inverse agonist, was employed to suppress ERRa activity in human non-small cell lung cancer cells (NSCLC) A549. Gene expressions were detected using quantitative real-time PCR and Western blot analysis. Mitochondrial mass, membrane potential and reactive oxygen species (ROS) production were measured by staining with Mitotracker green, JC-1 and CM-H(2)DCFDA dyes respectively. Rate of progression through the tricarboxylic acid (TCA) cycle was analysed by measuring activities of citrate synthase and succinate dehydrogenase. Cell cycle analysis was performed by using flow cytometry.. We found that XCT-790 treatment reduced mitochondrial mass but enhanced mitochondrial ROS production by increasing rate through the TCA cycle, elevating mitochondrial membrane potential (DeltaPsi(m)) and down-regulating expression of superoxide dismutase. It was further demonstrated that XCT-790-induced ROS modulated p53 and Rb signalling pathways and suppressed cell replication.. ERRalpha affects cell cycle mechanisms through modulating mitochondrial mass and function. Dysregulation of this essential pathway leads to elevation in mitochondrial ROS production, which in turn modulates activities of tumour suppressors, resulting in cell cycle arrest.

Topics: Benzimidazoles; Carbocyanines; Carcinoma, Non-Small-Cell Lung; Cell Cycle; Cell Line, Tumor; Dose-Response Relationship, Drug; ERRalpha Estrogen-Related Receptor; Fluorescent Dyes; Humans; Lung; Lung Neoplasms; Membrane Potential, Mitochondrial; Membrane Potentials; Mitochondria; Nitriles; Reactive Oxygen Species; Receptors, Estrogen; Signal Transduction; Superoxide Dismutase; Thiazoles; Time Factors; Tumor Suppressor Protein p53

2010