5-10-methylenetetrahydrofolic-acid and Neural-Tube-Defects

5-10-methylenetetrahydrofolic-acid has been researched along with Neural-Tube-Defects* in 2 studies

Other Studies

2 other study(ies) available for 5-10-methylenetetrahydrofolic-acid and Neural-Tube-Defects

Article	Year
Polymorphisms of 5,10-Methylenetetrahydrofolate reductase and cystathionine beta-synthase genes as a risk factor for neural tube defects in Sétif, Algeria. Concerning the article by Houcher et al., Pediatr Neurosurg 2009;45:472-477. Pediatric neurosurgery, 2009, Volume: 45, Issue:6 Topics: Adult; Algeria; Cystathionine beta-Synthase; Female; Gene Expression Regulation, Developmental; Genetic Predisposition to Disease; Humans; Infant, Newborn; Male; Methylenetetrahydrofolate Reductase (NADPH2); Neural Tube Defects; Polymorphism, Genetic; Pregnancy; Prevalence; Risk Factors; Tetrahydrofolates	2009
Embryonic folate metabolism and mouse neural tube defects. Science (New York, N.Y.), 1998, Jun-26, Volume: 280, Issue:5372 Folic acid prevents 70 percent of human neural tube defects (NTDs) but its mode of action is unclear. The deoxyuridine suppression test detects disturbance of folate metabolism in homozygous splotch (Pax3) mouse embryos that are developing NTDs in vitro. Excessive incorporation of [3H]thymidine in splotch embryos indicates a metabolic deficiency in the supply of folate for the biosynthesis of pyrimidine. Exogenous folic acid and thymidine both correct the biosynthetic defect and prevent some NTDs in splotch homozygotes, whereas methionine has an exacerbating effect. These data support a direct normalization of neurulation by folic acid in humans and suggest a metabolic basis for folate action. Topics: Animals; Central Nervous System; Deoxyuracil Nucleotides; DNA-Binding Proteins; Embryo, Mammalian; Female; Folic Acid; Humans; Male; Methionine; Mice; Mice, Inbred CBA; Mutation; Neural Tube Defects; Paired Box Transcription Factors; PAX3 Transcription Factor; Pyrimidines; Tetrahydrofolates; Thymidine; Thymidine Monophosphate; Transcription Factors	1998

Article

Year

Polymorphisms of 5,10-Methylenetetrahydrofolate reductase and cystathionine beta-synthase genes as a risk factor for neural tube defects in Sétif, Algeria. Concerning the article by Houcher et al., Pediatr Neurosurg 2009;45:472-477.

Pediatric neurosurgery, 2009, Volume: 45, Issue:6

Topics: Adult; Algeria; Cystathionine beta-Synthase; Female; Gene Expression Regulation, Developmental; Genetic Predisposition to Disease; Humans; Infant, Newborn; Male; Methylenetetrahydrofolate Reductase (NADPH2); Neural Tube Defects; Polymorphism, Genetic; Pregnancy; Prevalence; Risk Factors; Tetrahydrofolates

2009

Embryonic folate metabolism and mouse neural tube defects.

Science (New York, N.Y.), 1998, Jun-26, Volume: 280, Issue:5372

Folic acid prevents 70 percent of human neural tube defects (NTDs) but its mode of action is unclear. The deoxyuridine suppression test detects disturbance of folate metabolism in homozygous splotch (Pax3) mouse embryos that are developing NTDs in vitro. Excessive incorporation of [3H]thymidine in splotch embryos indicates a metabolic deficiency in the supply of folate for the biosynthesis of pyrimidine. Exogenous folic acid and thymidine both correct the biosynthetic defect and prevent some NTDs in splotch homozygotes, whereas methionine has an exacerbating effect. These data support a direct normalization of neurulation by folic acid in humans and suggest a metabolic basis for folate action.

Topics: Animals; Central Nervous System; Deoxyuracil Nucleotides; DNA-Binding Proteins; Embryo, Mammalian; Female; Folic Acid; Humans; Male; Methionine; Mice; Mice, Inbred CBA; Mutation; Neural Tube Defects; Paired Box Transcription Factors; PAX3 Transcription Factor; Pyrimidines; Tetrahydrofolates; Thymidine; Thymidine Monophosphate; Transcription Factors

1998