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5-(dimethylamino)-n-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide and Hypertension

5-(dimethylamino)-n-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide has been researched along with Hypertension in 16 studies

*Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more. [MeSH]

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (25.00)18.2507
2000's12 (75.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Dickey, J; Dickinson, KE; Floyd, DM; Hunt, JT; Liu, EC; Mitchell, C; Moreland, S; Murugesan, N; Stein, PD; Webb, ML1
Barrish, JC; Bird, E; Gu, Z; Leith, L; Liu, EC; Marino, A; Mathur, A; Moreland, S; Morrison, RA; Murugesan, N; Spergel, S; Stein, PD; Waldron, T; Webb, ML; Zhang, R1
Chen, X; He, G; Schiffrin, EL; Tostes, RC; Touyz, RM1
Belloni, AS; Kreutz, R; Nussdorfer, GG; Paul, M; Pessina, AC; Rossi, GP; Seccia, TM1
Callera, GE; Carvalho, MH; Fortes, ZB; Muscara, MN; Nigro, D; Schiffrin, EL; Teixeira, SA; Tostes, RC; Touyz, RM1
Callera, GE; Carvalho, MH; Fortes, ZB; Montezano, AC; Nigro, D; Schiffrin, EL; Tostes, RC; Touyz, RM; Zorn, TM1
Callera, GE; Carvalho, MH; Fortes, ZB; Montezano, AC; Mota, AL; Nigro, D; Tostes, RC; Zorn, TM1
Callera, GE; Montezano, AC; Tostes, RC; Touyz, RM; Yogi, A1
Bird, JE; Moreland, S; Powell, JR; Waldron, TL1
Asaad, MM; Bird, JE; Chao, C; Dorso, CR; Giancarli, MR; Webb, ML1
Gopalakrishnan, V; McNeill, JR; Yu, M1
Bahcelioglu, M; Belloni, AS; Bova, S; Mazzocchi, G; Nussdorfer, GG; Pessina, AC; Porteri, E; Rizzoni, D; Rossi, GP; Sacchetto, A1
Schiffrin, EL; Touyz, RM; Turgeon, A1
Park, JB; Schiffrin, EL1
Belloni, AS; Cavallin, M; Mazzocchi, G; Nussdorfer, GG; Pessina, AC; Rossi, GP; Sartore, S1
Calderone, A; Clement, R; Colombo, F; Gosselin, H; Mercier, I; Pham-Dang, M; Rouleau, JL1

Other Studies

16 other study(ies) available for 5-(dimethylamino)-n-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide and Hypertension

ArticleYear
The discovery of sulfonamide endothelin antagonists and the development of the orally active ETA antagonist 5-(dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulf onamide.
    Journal of medicinal chemistry, 1994, Feb-04, Volume: 37, Issue:3

    Topics: Animals; Antihypertensive Agents; Cell Line; Dansyl Compounds; Endothelin Receptor Antagonists; Endothelins; Hypertension; Molecular Structure; Muscle, Smooth, Vascular; Rabbits; Rats; Structure-Activity Relationship

1994
Biphenylsulfonamide endothelin receptor antagonists. 2. Discovery of 4'-oxazolyl biphenylsulfonamides as a new class of potent, highly selective ET(A) antagonists.
    Journal of medicinal chemistry, 2000, Aug-10, Volume: 43, Issue:16

    Topics: Administration, Oral; Animals; Biological Availability; Blood Pressure; Carotid Arteries; Drug Evaluation, Preclinical; Endothelin Receptor Antagonists; Hypertension; In Vitro Techniques; Injections, Intravenous; Macaca fascicularis; Muscle Contraction; Muscle, Smooth, Vascular; Oxazoles; Rabbits; Radioligand Assay; Rats; Receptor, Endothelin A; Structure-Activity Relationship; Sulfonamides

2000
Contribution of endothelin-1 to renal activator protein-1 activation and macrophage infiltration in aldosterone-induced hypertension.
    Clinical science (London, England : 1979), 2002, Volume: 103 Suppl 48

    Topics: Aldosterone; Analysis of Variance; Animals; Dansyl Compounds; DNA; Electrophoretic Mobility Shift Assay; Endothelin Receptor Antagonists; Endothelin-1; Hypertension; Immunohistochemistry; Kidney; Macrophages; Male; Mineralocorticoid Receptor Antagonists; NF-kappa B; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Spironolactone; Transcription Factor AP-1

2002
Cardiac fibrosis occurs early and involves endothelin and AT-1 receptors in hypertension due to endogenous angiotensin II.
    Journal of the American College of Cardiology, 2003, Feb-19, Volume: 41, Issue:4

    Topics: Angiotensin II; Animals; Animals, Genetically Modified; Antihypertensive Agents; Biphenyl Compounds; Bosentan; Cardiomyopathies; Dansyl Compounds; Disease Models, Animal; Endothelin-1; Fibrosis; Hypertension; Irbesartan; Male; Rats; Receptor, Angiotensin, Type 1; Receptors, Angiotensin; Receptors, Cell Surface; Sulfonamides; Tetrazoles; Time Factors; Vasoconstrictor Agents

2003
ETA receptor blockade decreases vascular superoxide generation in DOCA-salt hypertension.
    Hypertension (Dallas, Tex. : 1979), 2003, Volume: 42, Issue:4

    Topics: Acetylcholine; Animals; Aorta; Arterioles; Blood Pressure; Culture Techniques; Dansyl Compounds; Desoxycorticosterone; Endothelin Receptor Antagonists; Hypertension; Male; Neutrophils; Oxidative Stress; Proteins; Rats; Rats, Wistar; Receptor, Endothelin A; Sodium Chloride; Superoxides; Tyrosine; Vasodilation; Vasodilator Agents

2003
ETA receptor mediates altered leukocyte-endothelial cell interaction and adhesion molecules expression in DOCA-salt rats.
    Hypertension (Dallas, Tex. : 1979), 2004, Volume: 43, Issue:4

    Topics: Animals; Cell Adhesion; Cell Adhesion Molecules; Chemotaxis, Leukocyte; Dansyl Compounds; Desoxycorticosterone; Disease Models, Animal; E-Selectin; Endothelin A Receptor Antagonists; Endothelin-1; Endothelium, Vascular; Gene Expression Regulation; Hypertension; Hypertension, Renovascular; Inflammation; Intercellular Adhesion Molecule-1; Leukocytes; Macrophages; Male; Myocardium; Nephrectomy; P-Selectin; Rats; Rats, Wistar; Receptor, Endothelin A; Reverse Transcriptase Polymerase Chain Reaction; Sodium Chloride, Dietary; Vascular Cell Adhesion Molecule-1

2004
Endothelin-1 contributes to the sexual differences in renal damage in DOCA-salt rats.
    Peptides, 2005, Volume: 26, Issue:8

    Topics: Animals; Dansyl Compounds; Desoxycorticosterone; Disease Models, Animal; Endothelin-1; Estrogens; Female; Hydralazine; Hypertension; Kidney; Kidney Diseases; Male; Ovariectomy; Progesterone; Rats; Rats, Wistar; Receptor, Endothelin A; RNA, Messenger; Sex Characteristics; Sodium Chloride

2005
Endothelin-1-induced oxidative stress in DOCA-salt hypertension involves NADPH-oxidase-independent mechanisms.
    Clinical science (London, England : 1979), 2006, Volume: 110, Issue:2

    Topics: Animals; Antihypertensive Agents; Aorta; Dansyl Compounds; Desoxycorticosterone; Endothelin A Receptor Antagonists; Endothelin-1; Endothelium, Vascular; Hypertension; Male; Mesenteric Arteries; Mitochondria; Models, Animal; Myocardium; NADPH Oxidases; Nitric Oxide Synthase Type III; Oxidative Stress; Rats; Rats, Wistar; Receptor, Endothelin A; Sodium Chloride, Dietary; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances; Xanthine Oxidase

2006
Antihypertensive effects of a novel endothelin-A receptor antagonist in rats.
    Hypertension (Dallas, Tex. : 1979), 1995, Volume: 25, Issue:6

    Topics: Animals; Antihypertensive Agents; Blood Pressure; Dansyl Compounds; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Hypertension; Male; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Receptors, Endothelin

1995
A role for endothelin ETA receptors in regulation of renal function in spontaneously hypertensive rats.
    European journal of pharmacology, 1995, Dec-27, Volume: 294, Issue:1

    Topics: Animals; Antihypertensive Agents; Blood Pressure; Dansyl Compounds; Endothelin Receptor Antagonists; Endothelins; Glomerular Filtration Rate; Hypertension; Kidney; Kinetics; Male; Radioligand Assay; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Receptors, Endothelin; Renal Circulation

1995
Hemodynamic effects of a selective endothelin--a receptor antagonist in deoxycorticosterone acetate-salt hypertensive rats.
    Journal of cardiovascular pharmacology, 1998, Volume: 31 Suppl 1

    Topics: Animals; Antihypertensive Agents; Blood Pressure; Cardiac Output; Dansyl Compounds; Desoxycorticosterone; Endothelin Receptor Antagonists; Hemodynamics; Hypertension; Male; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Regional Blood Flow; Vascular Resistance

1998
Blockade of angiotensin II type 1 receptor and not of endothelin receptor prevents hypertension and cardiovascular disease in transgenic (mREN2)27 rats via adrenocortical steroid-independent mechanisms.
    Arteriosclerosis, thrombosis, and vascular biology, 2000, Volume: 20, Issue:4

    Topics: Adrenal Cortex Hormones; Angiotensin Receptor Antagonists; Animals; Animals, Genetically Modified; Antihypertensive Agents; Aorta; Arteries; Biphenyl Compounds; Bosentan; Cardiovascular Diseases; Dansyl Compounds; Endothelin Receptor Antagonists; Endothelium, Vascular; Hypertension; Irbesartan; Male; Mice; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Receptors, Endothelin; Renin; Sulfonamides; Tetrazoles

2000
Endothelin-A-receptor blockade improves renal function and doubles the lifespan of stroke-prone spontaneously hypertensive rats.
    Journal of cardiovascular pharmacology, 2000, Volume: 36, Issue:5 Suppl 1

    Topics: Animals; Antihypertensive Agents; Blood Pressure; Body Weight; Dansyl Compounds; Endothelin Receptor Antagonists; Female; Hypertension; Kidney; Male; Rats; Rats, Inbred SHR; Receptor, Endothelin A; Stroke

2000
ET(A) receptor antagonist prevents blood pressure elevation and vascular remodeling in aldosterone-infused rats.
    Hypertension (Dallas, Tex. : 1979), 2001, Volume: 37, Issue:6

    Topics: Aldosterone; Animals; Antihypertensive Agents; Aorta; Blood Pressure; Body Weight; Dansyl Compounds; Endothelin Receptor Antagonists; Endothelin-1; Endothelins; Hypertension; Hypertrophy; Infusions, Parenteral; Male; Mesenteric Arteries; Potassium; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; RNA, Messenger; Vasoconstriction; Vasodilation

2001
Aortic smooth muscle cell phenotypic modulation and fibrillar collagen deposition in angiotensin II-dependent hypertension.
    Cardiovascular research, 2002, Volume: 55, Issue:1

    Topics: Analysis of Variance; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Animals, Genetically Modified; Antihypertensive Agents; Aorta; Biphenyl Compounds; Bosentan; Calcium Channel Blockers; Collagen; Dansyl Compounds; Disease Models, Animal; Endothelin Receptor Antagonists; Endothelin-1; Hypertension; Immunohistochemistry; Irbesartan; Male; Muscle, Smooth, Vascular; Nifedipine; Rats; Rats, Sprague-Dawley; Sulfonamides; Tetrazoles

2002
Elevated mean arterial pressure in the ovariectomized rat was normalized by ET(A) receptor antagonist therapy: absence of cardiac hypertrophy and fibrosis.
    British journal of pharmacology, 2002, Volume: 136, Issue:5

    Topics: Animals; Blood Pressure; Dansyl Compounds; Endomyocardial Fibrosis; Endothelin Receptor Antagonists; Female; Hypertension; Hypertrophy, Left Ventricular; Ovariectomy; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptors, Endothelin

2002