5-(dimethylamino)-n-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide has been researched along with Hypertension in 16 studies
*Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more. [MeSH]
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (25.00) | 18.2507 |
| 2000's | 12 (75.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dickey, J; Dickinson, KE; Floyd, DM; Hunt, JT; Liu, EC; Mitchell, C; Moreland, S; Murugesan, N; Stein, PD; Webb, ML | 1 |
| Barrish, JC; Bird, E; Gu, Z; Leith, L; Liu, EC; Marino, A; Mathur, A; Moreland, S; Morrison, RA; Murugesan, N; Spergel, S; Stein, PD; Waldron, T; Webb, ML; Zhang, R | 1 |
| Chen, X; He, G; Schiffrin, EL; Tostes, RC; Touyz, RM | 1 |
| Belloni, AS; Kreutz, R; Nussdorfer, GG; Paul, M; Pessina, AC; Rossi, GP; Seccia, TM | 1 |
| Callera, GE; Carvalho, MH; Fortes, ZB; Muscara, MN; Nigro, D; Schiffrin, EL; Teixeira, SA; Tostes, RC; Touyz, RM | 1 |
| Callera, GE; Carvalho, MH; Fortes, ZB; Montezano, AC; Nigro, D; Schiffrin, EL; Tostes, RC; Touyz, RM; Zorn, TM | 1 |
| Callera, GE; Carvalho, MH; Fortes, ZB; Montezano, AC; Mota, AL; Nigro, D; Tostes, RC; Zorn, TM | 1 |
| Callera, GE; Montezano, AC; Tostes, RC; Touyz, RM; Yogi, A | 1 |
| Bird, JE; Moreland, S; Powell, JR; Waldron, TL | 1 |
| Asaad, MM; Bird, JE; Chao, C; Dorso, CR; Giancarli, MR; Webb, ML | 1 |
| Gopalakrishnan, V; McNeill, JR; Yu, M | 1 |
| Bahcelioglu, M; Belloni, AS; Bova, S; Mazzocchi, G; Nussdorfer, GG; Pessina, AC; Porteri, E; Rizzoni, D; Rossi, GP; Sacchetto, A | 1 |
| Schiffrin, EL; Touyz, RM; Turgeon, A | 1 |
| Park, JB; Schiffrin, EL | 1 |
| Belloni, AS; Cavallin, M; Mazzocchi, G; Nussdorfer, GG; Pessina, AC; Rossi, GP; Sartore, S | 1 |
| Calderone, A; Clement, R; Colombo, F; Gosselin, H; Mercier, I; Pham-Dang, M; Rouleau, JL | 1 |
16 other study(ies) available for 5-(dimethylamino)-n-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide and Hypertension
| Article | Year |
|---|---|
The discovery of sulfonamide endothelin antagonists and the development of the orally active ETA antagonist 5-(dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulf onamide.
Topics: Animals; Antihypertensive Agents; Cell Line; Dansyl Compounds; Endothelin Receptor Antagonists; Endothelins; Hypertension; Molecular Structure; Muscle, Smooth, Vascular; Rabbits; Rats; Structure-Activity Relationship | 1994 |
Biphenylsulfonamide endothelin receptor antagonists. 2. Discovery of 4'-oxazolyl biphenylsulfonamides as a new class of potent, highly selective ET(A) antagonists.
Topics: Administration, Oral; Animals; Biological Availability; Blood Pressure; Carotid Arteries; Drug Evaluation, Preclinical; Endothelin Receptor Antagonists; Hypertension; In Vitro Techniques; Injections, Intravenous; Macaca fascicularis; Muscle Contraction; Muscle, Smooth, Vascular; Oxazoles; Rabbits; Radioligand Assay; Rats; Receptor, Endothelin A; Structure-Activity Relationship; Sulfonamides | 2000 |
Contribution of endothelin-1 to renal activator protein-1 activation and macrophage infiltration in aldosterone-induced hypertension.
Topics: Aldosterone; Analysis of Variance; Animals; Dansyl Compounds; DNA; Electrophoretic Mobility Shift Assay; Endothelin Receptor Antagonists; Endothelin-1; Hypertension; Immunohistochemistry; Kidney; Macrophages; Male; Mineralocorticoid Receptor Antagonists; NF-kappa B; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Spironolactone; Transcription Factor AP-1 | 2002 |
Cardiac fibrosis occurs early and involves endothelin and AT-1 receptors in hypertension due to endogenous angiotensin II.
Topics: Angiotensin II; Animals; Animals, Genetically Modified; Antihypertensive Agents; Biphenyl Compounds; Bosentan; Cardiomyopathies; Dansyl Compounds; Disease Models, Animal; Endothelin-1; Fibrosis; Hypertension; Irbesartan; Male; Rats; Receptor, Angiotensin, Type 1; Receptors, Angiotensin; Receptors, Cell Surface; Sulfonamides; Tetrazoles; Time Factors; Vasoconstrictor Agents | 2003 |
ETA receptor blockade decreases vascular superoxide generation in DOCA-salt hypertension.
Topics: Acetylcholine; Animals; Aorta; Arterioles; Blood Pressure; Culture Techniques; Dansyl Compounds; Desoxycorticosterone; Endothelin Receptor Antagonists; Hypertension; Male; Neutrophils; Oxidative Stress; Proteins; Rats; Rats, Wistar; Receptor, Endothelin A; Sodium Chloride; Superoxides; Tyrosine; Vasodilation; Vasodilator Agents | 2003 |
ETA receptor mediates altered leukocyte-endothelial cell interaction and adhesion molecules expression in DOCA-salt rats.
Topics: Animals; Cell Adhesion; Cell Adhesion Molecules; Chemotaxis, Leukocyte; Dansyl Compounds; Desoxycorticosterone; Disease Models, Animal; E-Selectin; Endothelin A Receptor Antagonists; Endothelin-1; Endothelium, Vascular; Gene Expression Regulation; Hypertension; Hypertension, Renovascular; Inflammation; Intercellular Adhesion Molecule-1; Leukocytes; Macrophages; Male; Myocardium; Nephrectomy; P-Selectin; Rats; Rats, Wistar; Receptor, Endothelin A; Reverse Transcriptase Polymerase Chain Reaction; Sodium Chloride, Dietary; Vascular Cell Adhesion Molecule-1 | 2004 |
Endothelin-1 contributes to the sexual differences in renal damage in DOCA-salt rats.
Topics: Animals; Dansyl Compounds; Desoxycorticosterone; Disease Models, Animal; Endothelin-1; Estrogens; Female; Hydralazine; Hypertension; Kidney; Kidney Diseases; Male; Ovariectomy; Progesterone; Rats; Rats, Wistar; Receptor, Endothelin A; RNA, Messenger; Sex Characteristics; Sodium Chloride | 2005 |
Endothelin-1-induced oxidative stress in DOCA-salt hypertension involves NADPH-oxidase-independent mechanisms.
Topics: Animals; Antihypertensive Agents; Aorta; Dansyl Compounds; Desoxycorticosterone; Endothelin A Receptor Antagonists; Endothelin-1; Endothelium, Vascular; Hypertension; Male; Mesenteric Arteries; Mitochondria; Models, Animal; Myocardium; NADPH Oxidases; Nitric Oxide Synthase Type III; Oxidative Stress; Rats; Rats, Wistar; Receptor, Endothelin A; Sodium Chloride, Dietary; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances; Xanthine Oxidase | 2006 |
Antihypertensive effects of a novel endothelin-A receptor antagonist in rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Dansyl Compounds; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Hypertension; Male; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Receptors, Endothelin | 1995 |
A role for endothelin ETA receptors in regulation of renal function in spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Dansyl Compounds; Endothelin Receptor Antagonists; Endothelins; Glomerular Filtration Rate; Hypertension; Kidney; Kinetics; Male; Radioligand Assay; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Receptors, Endothelin; Renal Circulation | 1995 |
Hemodynamic effects of a selective endothelin--a receptor antagonist in deoxycorticosterone acetate-salt hypertensive rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Cardiac Output; Dansyl Compounds; Desoxycorticosterone; Endothelin Receptor Antagonists; Hemodynamics; Hypertension; Male; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Regional Blood Flow; Vascular Resistance | 1998 |
Blockade of angiotensin II type 1 receptor and not of endothelin receptor prevents hypertension and cardiovascular disease in transgenic (mREN2)27 rats via adrenocortical steroid-independent mechanisms.
Topics: Adrenal Cortex Hormones; Angiotensin Receptor Antagonists; Animals; Animals, Genetically Modified; Antihypertensive Agents; Aorta; Arteries; Biphenyl Compounds; Bosentan; Cardiovascular Diseases; Dansyl Compounds; Endothelin Receptor Antagonists; Endothelium, Vascular; Hypertension; Irbesartan; Male; Mice; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Receptors, Endothelin; Renin; Sulfonamides; Tetrazoles | 2000 |
Endothelin-A-receptor blockade improves renal function and doubles the lifespan of stroke-prone spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Body Weight; Dansyl Compounds; Endothelin Receptor Antagonists; Female; Hypertension; Kidney; Male; Rats; Rats, Inbred SHR; Receptor, Endothelin A; Stroke | 2000 |
ET(A) receptor antagonist prevents blood pressure elevation and vascular remodeling in aldosterone-infused rats.
Topics: Aldosterone; Animals; Antihypertensive Agents; Aorta; Blood Pressure; Body Weight; Dansyl Compounds; Endothelin Receptor Antagonists; Endothelin-1; Endothelins; Hypertension; Hypertrophy; Infusions, Parenteral; Male; Mesenteric Arteries; Potassium; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; RNA, Messenger; Vasoconstriction; Vasodilation | 2001 |
Aortic smooth muscle cell phenotypic modulation and fibrillar collagen deposition in angiotensin II-dependent hypertension.
Topics: Analysis of Variance; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Animals, Genetically Modified; Antihypertensive Agents; Aorta; Biphenyl Compounds; Bosentan; Calcium Channel Blockers; Collagen; Dansyl Compounds; Disease Models, Animal; Endothelin Receptor Antagonists; Endothelin-1; Hypertension; Immunohistochemistry; Irbesartan; Male; Muscle, Smooth, Vascular; Nifedipine; Rats; Rats, Sprague-Dawley; Sulfonamides; Tetrazoles | 2002 |
Elevated mean arterial pressure in the ovariectomized rat was normalized by ET(A) receptor antagonist therapy: absence of cardiac hypertrophy and fibrosis.
Topics: Animals; Blood Pressure; Dansyl Compounds; Endomyocardial Fibrosis; Endothelin Receptor Antagonists; Female; Hypertension; Hypertrophy, Left Ventricular; Ovariectomy; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptors, Endothelin | 2002 |