5-(dimethylamino)-n-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide has been researched along with Blood Pressure, High in 16 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (25.00) | 18.2507 |
| 2000's | 12 (75.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dickey, J; Dickinson, KE; Floyd, DM; Hunt, JT; Liu, EC; Mitchell, C; Moreland, S; Murugesan, N; Stein, PD; Webb, ML | 1 |
| Barrish, JC; Bird, E; Gu, Z; Leith, L; Liu, EC; Marino, A; Mathur, A; Moreland, S; Morrison, RA; Murugesan, N; Spergel, S; Stein, PD; Waldron, T; Webb, ML; Zhang, R | 1 |
| Chen, X; He, G; Schiffrin, EL; Tostes, RC; Touyz, RM | 1 |
| Belloni, AS; Kreutz, R; Nussdorfer, GG; Paul, M; Pessina, AC; Rossi, GP; Seccia, TM | 1 |
| Callera, GE; Carvalho, MH; Fortes, ZB; Muscara, MN; Nigro, D; Schiffrin, EL; Teixeira, SA; Tostes, RC; Touyz, RM | 1 |
| Callera, GE; Carvalho, MH; Fortes, ZB; Montezano, AC; Nigro, D; Schiffrin, EL; Tostes, RC; Touyz, RM; Zorn, TM | 1 |
| Callera, GE; Carvalho, MH; Fortes, ZB; Montezano, AC; Mota, AL; Nigro, D; Tostes, RC; Zorn, TM | 1 |
| Callera, GE; Montezano, AC; Tostes, RC; Touyz, RM; Yogi, A | 1 |
| Bird, JE; Moreland, S; Powell, JR; Waldron, TL | 1 |
| Asaad, MM; Bird, JE; Chao, C; Dorso, CR; Giancarli, MR; Webb, ML | 1 |
| Gopalakrishnan, V; McNeill, JR; Yu, M | 1 |
| Bahcelioglu, M; Belloni, AS; Bova, S; Mazzocchi, G; Nussdorfer, GG; Pessina, AC; Porteri, E; Rizzoni, D; Rossi, GP; Sacchetto, A | 1 |
| Schiffrin, EL; Touyz, RM; Turgeon, A | 1 |
| Park, JB; Schiffrin, EL | 1 |
| Belloni, AS; Cavallin, M; Mazzocchi, G; Nussdorfer, GG; Pessina, AC; Rossi, GP; Sartore, S | 1 |
| Calderone, A; Clement, R; Colombo, F; Gosselin, H; Mercier, I; Pham-Dang, M; Rouleau, JL | 1 |
16 other study(ies) available for 5-(dimethylamino)-n-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide and Blood Pressure, High
| Article | Year |
|---|---|
The discovery of sulfonamide endothelin antagonists and the development of the orally active ETA antagonist 5-(dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulf onamide.
Topics: Animals; Antihypertensive Agents; Cell Line; Dansyl Compounds; Endothelin Receptor Antagonists; Endothelins; Hypertension; Molecular Structure; Muscle, Smooth, Vascular; Rabbits; Rats; Structure-Activity Relationship | 1994 |
Biphenylsulfonamide endothelin receptor antagonists. 2. Discovery of 4'-oxazolyl biphenylsulfonamides as a new class of potent, highly selective ET(A) antagonists.
Topics: Administration, Oral; Animals; Biological Availability; Blood Pressure; Carotid Arteries; Drug Evaluation, Preclinical; Endothelin Receptor Antagonists; Hypertension; In Vitro Techniques; Injections, Intravenous; Macaca fascicularis; Muscle Contraction; Muscle, Smooth, Vascular; Oxazoles; Rabbits; Radioligand Assay; Rats; Receptor, Endothelin A; Structure-Activity Relationship; Sulfonamides | 2000 |
Contribution of endothelin-1 to renal activator protein-1 activation and macrophage infiltration in aldosterone-induced hypertension.
Topics: Aldosterone; Analysis of Variance; Animals; Dansyl Compounds; DNA; Electrophoretic Mobility Shift Assay; Endothelin Receptor Antagonists; Endothelin-1; Hypertension; Immunohistochemistry; Kidney; Macrophages; Male; Mineralocorticoid Receptor Antagonists; NF-kappa B; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Spironolactone; Transcription Factor AP-1 | 2002 |
Cardiac fibrosis occurs early and involves endothelin and AT-1 receptors in hypertension due to endogenous angiotensin II.
Topics: Angiotensin II; Animals; Animals, Genetically Modified; Antihypertensive Agents; Biphenyl Compounds; Bosentan; Cardiomyopathies; Dansyl Compounds; Disease Models, Animal; Endothelin-1; Fibrosis; Hypertension; Irbesartan; Male; Rats; Receptor, Angiotensin, Type 1; Receptors, Angiotensin; Receptors, Cell Surface; Sulfonamides; Tetrazoles; Time Factors; Vasoconstrictor Agents | 2003 |
ETA receptor blockade decreases vascular superoxide generation in DOCA-salt hypertension.
Topics: Acetylcholine; Animals; Aorta; Arterioles; Blood Pressure; Culture Techniques; Dansyl Compounds; Desoxycorticosterone; Endothelin Receptor Antagonists; Hypertension; Male; Neutrophils; Oxidative Stress; Proteins; Rats; Rats, Wistar; Receptor, Endothelin A; Sodium Chloride; Superoxides; Tyrosine; Vasodilation; Vasodilator Agents | 2003 |
ETA receptor mediates altered leukocyte-endothelial cell interaction and adhesion molecules expression in DOCA-salt rats.
Topics: Animals; Cell Adhesion; Cell Adhesion Molecules; Chemotaxis, Leukocyte; Dansyl Compounds; Desoxycorticosterone; Disease Models, Animal; E-Selectin; Endothelin A Receptor Antagonists; Endothelin-1; Endothelium, Vascular; Gene Expression Regulation; Hypertension; Hypertension, Renovascular; Inflammation; Intercellular Adhesion Molecule-1; Leukocytes; Macrophages; Male; Myocardium; Nephrectomy; P-Selectin; Rats; Rats, Wistar; Receptor, Endothelin A; Reverse Transcriptase Polymerase Chain Reaction; Sodium Chloride, Dietary; Vascular Cell Adhesion Molecule-1 | 2004 |
Endothelin-1 contributes to the sexual differences in renal damage in DOCA-salt rats.
Topics: Animals; Dansyl Compounds; Desoxycorticosterone; Disease Models, Animal; Endothelin-1; Estrogens; Female; Hydralazine; Hypertension; Kidney; Kidney Diseases; Male; Ovariectomy; Progesterone; Rats; Rats, Wistar; Receptor, Endothelin A; RNA, Messenger; Sex Characteristics; Sodium Chloride | 2005 |
Endothelin-1-induced oxidative stress in DOCA-salt hypertension involves NADPH-oxidase-independent mechanisms.
Topics: Animals; Antihypertensive Agents; Aorta; Dansyl Compounds; Desoxycorticosterone; Endothelin A Receptor Antagonists; Endothelin-1; Endothelium, Vascular; Hypertension; Male; Mesenteric Arteries; Mitochondria; Models, Animal; Myocardium; NADPH Oxidases; Nitric Oxide Synthase Type III; Oxidative Stress; Rats; Rats, Wistar; Receptor, Endothelin A; Sodium Chloride, Dietary; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances; Xanthine Oxidase | 2006 |
Antihypertensive effects of a novel endothelin-A receptor antagonist in rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Dansyl Compounds; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Hypertension; Male; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Receptors, Endothelin | 1995 |
A role for endothelin ETA receptors in regulation of renal function in spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Dansyl Compounds; Endothelin Receptor Antagonists; Endothelins; Glomerular Filtration Rate; Hypertension; Kidney; Kinetics; Male; Radioligand Assay; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Receptors, Endothelin; Renal Circulation | 1995 |
Hemodynamic effects of a selective endothelin--a receptor antagonist in deoxycorticosterone acetate-salt hypertensive rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Cardiac Output; Dansyl Compounds; Desoxycorticosterone; Endothelin Receptor Antagonists; Hemodynamics; Hypertension; Male; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Regional Blood Flow; Vascular Resistance | 1998 |
Blockade of angiotensin II type 1 receptor and not of endothelin receptor prevents hypertension and cardiovascular disease in transgenic (mREN2)27 rats via adrenocortical steroid-independent mechanisms.
Topics: Adrenal Cortex Hormones; Angiotensin Receptor Antagonists; Animals; Animals, Genetically Modified; Antihypertensive Agents; Aorta; Arteries; Biphenyl Compounds; Bosentan; Cardiovascular Diseases; Dansyl Compounds; Endothelin Receptor Antagonists; Endothelium, Vascular; Hypertension; Irbesartan; Male; Mice; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Receptors, Endothelin; Renin; Sulfonamides; Tetrazoles | 2000 |
Endothelin-A-receptor blockade improves renal function and doubles the lifespan of stroke-prone spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Body Weight; Dansyl Compounds; Endothelin Receptor Antagonists; Female; Hypertension; Kidney; Male; Rats; Rats, Inbred SHR; Receptor, Endothelin A; Stroke | 2000 |
ET(A) receptor antagonist prevents blood pressure elevation and vascular remodeling in aldosterone-infused rats.
Topics: Aldosterone; Animals; Antihypertensive Agents; Aorta; Blood Pressure; Body Weight; Dansyl Compounds; Endothelin Receptor Antagonists; Endothelin-1; Endothelins; Hypertension; Hypertrophy; Infusions, Parenteral; Male; Mesenteric Arteries; Potassium; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; RNA, Messenger; Vasoconstriction; Vasodilation | 2001 |
Aortic smooth muscle cell phenotypic modulation and fibrillar collagen deposition in angiotensin II-dependent hypertension.
Topics: Analysis of Variance; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Animals, Genetically Modified; Antihypertensive Agents; Aorta; Biphenyl Compounds; Bosentan; Calcium Channel Blockers; Collagen; Dansyl Compounds; Disease Models, Animal; Endothelin Receptor Antagonists; Endothelin-1; Hypertension; Immunohistochemistry; Irbesartan; Male; Muscle, Smooth, Vascular; Nifedipine; Rats; Rats, Sprague-Dawley; Sulfonamides; Tetrazoles | 2002 |
Elevated mean arterial pressure in the ovariectomized rat was normalized by ET(A) receptor antagonist therapy: absence of cardiac hypertrophy and fibrosis.
Topics: Animals; Blood Pressure; Dansyl Compounds; Endomyocardial Fibrosis; Endothelin Receptor Antagonists; Female; Hypertension; Hypertrophy, Left Ventricular; Ovariectomy; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptors, Endothelin | 2002 |