Compounds > 5-(alpha-methyl-4-bromobenzylamino)phosphonomethyl-1-4-dihydroquinoxaline-2-3-dione

5-(alpha-methyl-4-bromobenzylamino)phosphonomethyl-1-4-dihydroquinoxaline-2-3-dione and Migraine-Disorders

5-(alpha-methyl-4-bromobenzylamino)phosphonomethyl-1-4-dihydroquinoxaline-2-3-dione has been researched along with Migraine-Disorders* in 1 studies

Other Studies

1 other study(ies) available for 5-(alpha-methyl-4-bromobenzylamino)phosphonomethyl-1-4-dihydroquinoxaline-2-3-dione and Migraine-Disorders

ArticleYear
Sarcoma Family Kinase-Dependent Pannexin-1 Activation after Cortical Spreading Depression is Mediated by NR2A-Containing Receptors.
    International journal of molecular sciences, 2020, Feb-13, Volume: 21, Issue:4

    Cortical spreading depression (CSD) is a propagating wave of depolarization followed by depression of cortical activity. CSD triggers neuroinflammation via the pannexin-1 (Panx1) channel opening, which may eventually cause migraine headaches. However, the regulatory mechanism of Panx1 is unknown. This study investigates whether sarcoma family kinases (SFK) are involved in transmitting CSD-induced Panx1 activation, which is mediated by the NR2A-containing N-methyl-D-aspartate receptor. CSD was induced by topical application of K

    Topics: Animals; Cerebral Cortex; Connexins; Cortical Spreading Depression; Humans; Male; Mice; Migraine Disorders; Nerve Tissue Proteins; Phosphotransferases; Pyrimidines; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate

2020