5-(alpha-methyl-4-bromobenzylamino)phosphonomethyl-1-4-dihydroquinoxaline-2-3-dione has been researched along with Migraine-Disorders* in 1 studies
1 other study(ies) available for 5-(alpha-methyl-4-bromobenzylamino)phosphonomethyl-1-4-dihydroquinoxaline-2-3-dione and Migraine-Disorders
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Sarcoma Family Kinase-Dependent Pannexin-1 Activation after Cortical Spreading Depression is Mediated by NR2A-Containing Receptors.
Cortical spreading depression (CSD) is a propagating wave of depolarization followed by depression of cortical activity. CSD triggers neuroinflammation via the pannexin-1 (Panx1) channel opening, which may eventually cause migraine headaches. However, the regulatory mechanism of Panx1 is unknown. This study investigates whether sarcoma family kinases (SFK) are involved in transmitting CSD-induced Panx1 activation, which is mediated by the NR2A-containing N-methyl-D-aspartate receptor. CSD was induced by topical application of K Topics: Animals; Cerebral Cortex; Connexins; Cortical Spreading Depression; Humans; Male; Mice; Migraine Disorders; Nerve Tissue Proteins; Phosphotransferases; Pyrimidines; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate | 2020 |