Compounds > 5-(4-ethylbenzylidene)-2-thioxothiazolidin-4-one

5-(4-ethylbenzylidene)-2-thioxothiazolidin-4-one and Melanoma

5-(4-ethylbenzylidene)-2-thioxothiazolidin-4-one has been researched along with Melanoma* in 1 studies

Other Studies

1 other study(ies) available for 5-(4-ethylbenzylidene)-2-thioxothiazolidin-4-one and Melanoma

Article	Year
A strategy for combating melanoma with oncogenic c-Myc inhibitors and targeted nanotherapy. Nanomedicine (London, England), 2015, Volume: 10, Issue:2 The activity of the transcription factor c-Myc is dependent upon heterodimerization with Max to control target gene transcription. Small-molecule inhibitors of c-Myc-Max have exhibited low potency and poor water solubility and are therefore unsuitable for in vivo application. We hypothesized that a nanomedicine approach incorporating a cryptic c-Myc inhibitor prodrug could be delivered and enzymatically released in order to effectively inhibit melanoma.. An Sn-2 lipase-labile Myc inhibitor prodrug was synthesized and included in two αvβ3-targeted nanoparticle platforms (20 and 200 nm). The inherent antiproliferate potency was compared with the lipid-free compound using human and mouse melanoma cell lines.. These data demonstrate for the first time a successful nanodelivery of c-Myc inhibitors and their potential use to prevent melanoma. Topics: Animals; Cell Line, Tumor; Cell Survival; Humans; Melanoma; Mice; Nanomedicine; Nanoparticles; Prodrugs; Proto-Oncogene Proteins c-myc; Rats; Thiazoles	2015

Article

Year

A strategy for combating melanoma with oncogenic c-Myc inhibitors and targeted nanotherapy.

Nanomedicine (London, England), 2015, Volume: 10, Issue:2

The activity of the transcription factor c-Myc is dependent upon heterodimerization with Max to control target gene transcription. Small-molecule inhibitors of c-Myc-Max have exhibited low potency and poor water solubility and are therefore unsuitable for in vivo application. We hypothesized that a nanomedicine approach incorporating a cryptic c-Myc inhibitor prodrug could be delivered and enzymatically released in order to effectively inhibit melanoma.. An Sn-2 lipase-labile Myc inhibitor prodrug was synthesized and included in two αvβ3-targeted nanoparticle platforms (20 and 200 nm). The inherent antiproliferate potency was compared with the lipid-free compound using human and mouse melanoma cell lines.. These data demonstrate for the first time a successful nanodelivery of c-Myc inhibitors and their potential use to prevent melanoma.

Topics: Animals; Cell Line, Tumor; Cell Survival; Humans; Melanoma; Mice; Nanomedicine; Nanoparticles; Prodrugs; Proto-Oncogene Proteins c-myc; Rats; Thiazoles

2015