5-(2-iodovinyl)-2--deoxyuridine has been researched along with Glioblastoma* in 1 studies
1 other study(ies) available for 5-(2-iodovinyl)-2--deoxyuridine and Glioblastoma
| Article | Year |
|---|---|
Application of bioluminescence imaging to therapeutic intervention of herpes simplex virus type I - Thymidine kinase/ganciclovir in glioma.
Lentiviral vector containing the HSV1-tk and firefly luciferase (fLuc) gene was infected into C6 and C6-TL expressing HSV1-tk and fLuc gene was generated. C6-TL showed higher [(125)I]IVDU uptake than C6. The survival rate of C6-TL decreased more rapidly with increasing GCV dose and was well correlated with fLuc activity. The images of microPET clearly demonstrated higher uptake of [(18)F]FHBG into the C6-TL tumor. Inhibition of tumor growth was observed in C6-TL tumor-bearing mice treated with GCV through tumor size measurement and bioluminescence imaging. The therapeutic effect of HSV1-tk/GCV system can be monitored using bioluminescent imaging and tumor size measurement. Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Female; Ganciclovir; Genes, Reporter; Genes, Transgenic, Suicide; Genetic Therapy; Genetic Vectors; Glioblastoma; Herpesvirus 1, Human; Idoxuridine; Kinetics; Lentivirus; Luciferases, Firefly; Luminescent Measurements; Mice; Mice, Inbred BALB C; Mice, Nude; Positron-Emission Tomography; Rats; Recombinant Fusion Proteins; Thymidine Kinase; Tumor Burden | 2010 |