5-(2-chloroethyl)-2--deoxyuridine and Iritis

5-(2-chloroethyl)-2--deoxyuridine has been researched along with Iritis* in 1 studies

Other Studies

1 other study(ies) available for 5-(2-chloroethyl)-2--deoxyuridine and Iritis

ArticleYear
Ocular penetration and efficacy of chloroethyldeoxyuridine against herpetic keratouveitis.
    Investigative ophthalmology & visual science, 1986, Volume: 27, Issue:10

    Topical administration of 0.1% or 1% chloroethyldeoxyuridine eyedrops caused a significant reduction in the severity of experimental herpes simplex iritis and stromal keratitis in rabbits. The healing effect caused by chloroethyldeoxyuridine was comparable to that obtained with 0.1% and 0.5% bromovinylde-oxyuridine eyedrops. The drug levels achieved in the anterior chamber fluid following topical application of 1% eyedrops of [2-14C]CEDU, a radiolabelled analogue of chloroethyldeoxyuridine, were well above the minimum concentration (0.1 microgram/mL) required for inhibition of herpes simplex virus type 1 replication. The beneficial effects of chloroethyldeoxyuridine on stomal keratitis and iritis appear consistent with its efficient penetration through the cornea.

    Topics: Animals; Anterior Chamber; Antiviral Agents; Bromodeoxyuridine; Deoxyuridine; Iritis; Keratitis, Dendritic; Ophthalmic Solutions; Rabbits

1986