42-hydroxypalytoxin and Neuroblastoma

42-hydroxypalytoxin has been researched along with Neuroblastoma* in 1 studies

Other Studies

1 other study(ies) available for 42-hydroxypalytoxin and Neuroblastoma

Article	Year
First evidence of palytoxin and 42-hydroxy-palytoxin in the marine cyanobacterium Trichodesmium. Marine drugs, 2011, Volume: 9, Issue:4 Marine pelagic diazotrophic cyanobacteria of the genus Trichodesmium (Oscillatoriales) are widespread throughout the tropics and subtropics, and are particularly common in the waters of New Caledonia. Blooms of Trichodesmium are suspected to be a potential source of toxins in the ciguatera food chain and were previously reported to contain several types of paralyzing toxins. The toxicity of water-soluble extracts of Trichodesmium spp. were analyzed by mouse bioassay and Neuroblastoma assay and their toxic compounds characterized using liquid chromatography coupled with tandem mass spectrometry techniques. Here, we report the first identification of palytoxin and one of its derivatives, 42-hydroxy-palytoxin, in field samples of Trichodesmium collected in the New Caledonian lagoon. The possible role played by Trichodesmium blooms in the development of clupeotoxism, this human intoxication following the ingestion of plankton-eating fish and classically associated with Ostreopsis blooms, is also discussed. Topics: Acrylamides; Animals; Biological Assay; Cell Line, Tumor; Chromatography, Liquid; Cnidarian Venoms; Cyanobacteria; Female; Humans; Male; Mice; Neuroblastoma; Pyrans; Tandem Mass Spectrometry; Toxicity Tests	2011

Article

Year

First evidence of palytoxin and 42-hydroxy-palytoxin in the marine cyanobacterium Trichodesmium.

Marine drugs, 2011, Volume: 9, Issue:4

Marine pelagic diazotrophic cyanobacteria of the genus Trichodesmium (Oscillatoriales) are widespread throughout the tropics and subtropics, and are particularly common in the waters of New Caledonia. Blooms of Trichodesmium are suspected to be a potential source of toxins in the ciguatera food chain and were previously reported to contain several types of paralyzing toxins. The toxicity of water-soluble extracts of Trichodesmium spp. were analyzed by mouse bioassay and Neuroblastoma assay and their toxic compounds characterized using liquid chromatography coupled with tandem mass spectrometry techniques. Here, we report the first identification of palytoxin and one of its derivatives, 42-hydroxy-palytoxin, in field samples of Trichodesmium collected in the New Caledonian lagoon. The possible role played by Trichodesmium blooms in the development of clupeotoxism, this human intoxication following the ingestion of plankton-eating fish and classically associated with Ostreopsis blooms, is also discussed.

Topics: Acrylamides; Animals; Biological Assay; Cell Line, Tumor; Chromatography, Liquid; Cnidarian Venoms; Cyanobacteria; Female; Humans; Male; Mice; Neuroblastoma; Pyrans; Tandem Mass Spectrometry; Toxicity Tests

2011