4-toluoyl-chloride-phenylhydrazone and Ostertagiasis

A new anthelmintic candidate, p-toluoyl chloride phenlylhydrazone, was administered to lambs in a paste formulation. The efficacy of this drug was determined at dose rates of 20, 30, 40, and 50 mg of active ingredient per kilogram of body weight. Helminths expelled by these dosages included Haemonchus contortus, Ostertagia circumcicta, Trichostrongylus colubriformis, T. axei, Nematodirus filicollis, Cooperia curticei, Strongyloides papillosus, Oesophagostomum columbianum, Bunostomum trigoncephalum, Chabertia ovina, Moniezia expansa, and M. benedeni.

Topics: Animals; Anthelmintics; Benzoates; Haemonchiasis; Helminthiasis, Animal; Hydrazones; Intestinal Diseases, Parasitic; Monieziasis; Oesophagostomiasis; Ostertagiasis; Sheep; Sheep Diseases; Stomach Diseases; Trichostrongyloidiasis