4-stilbazole has been researched along with Colonic-Neoplasms* in 1 studies
1 other study(ies) available for 4-stilbazole and Colonic-Neoplasms
| Article | Year |
|---|---|
An efficient coupling of N-tosylhydrazones with 2-halopyridines: synthesis of 2-α-styrylpyridines endowed with antitumor activity.
The synthesis of 2-α-styrylpyridines has been carried out by using the coupling of polyoxygenated N-tosylhydrazones with various 2-halopyridines. We demonstrated that the use of a catalytic amount of PdCl2(MeCN)2 in combination with a bidentate ferrocene DPPF or a monodentate alkyl phosphine (t)Bu2MeP-HBF4 constitutes an efficient protocol for this coupling, providing 2-α-styrylpyridines 2 in satisfactory to good yields. Among several polyoxygenated derivatives 2 evaluated, compound 2aa was found to exhibit excellent antiproliferative and antimitotic activities comparable to that of the reference compound isoCA-4. Topics: Antineoplastic Agents; Catalysis; Cell Line, Tumor; Cell Proliferation; Colon; Colonic Neoplasms; Halogenation; Humans; Hydrazones; Palladium; Pyridines; Styrenes | 2013 |