4-phenylbutyric acid has been researched along with Anemia, Cooley's in 3 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (66.67) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Singer, ST | 1 |
| Kuypers, FA | 1 |
| Olivieri, NF | 1 |
| Weatherall, DJ | 1 |
| Mignacca, R | 1 |
| Coates, TD | 1 |
| Davies, S | 1 |
| Sweeters, N | 1 |
| Vichinsky, EP | 1 |
| Collins, AF | 1 |
| Pearson, HA | 1 |
| Giardina, P | 1 |
| McDonagh, KT | 1 |
| Brusilow, SW | 1 |
| Dover, GJ | 1 |
| Fibach, E | 1 |
| Prasanna, P | 1 |
| Rodgers, GP | 1 |
| Samid, D | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phenylbutyrate for Monogenetic Developmental and Epileptic Encephalopathy[NCT04937062] | Early Phase 1 | 50 participants (Anticipated) | Interventional | 2021-03-01 | Enrolling by invitation | ||
| A Phase 1b Sequential Open Label Dose-Ranging Study of Safety, Pharmacokinetics, and Preliminary Activity of Benserazide in Subjects With Beta Thalassemia Intermedia and Sickle Cell Disease[NCT04432623] | Phase 1/Phase 2 | 36 participants (Anticipated) | Interventional | 2020-10-05 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for 4-phenylbutyric acid and Anemia, Cooley's
| Article | Year |
|---|---|
Single and combination drug therapy for fetal hemoglobin augmentation in hemoglobin E-beta 0-thalassemia: Considerations for treatment.
Topics: beta-Thalassemia; Blood Transfusion; Combined Modality Therapy; Drug Therapy, Combination; Erythropo | 2005 |
Oral sodium phenylbutyrate therapy in homozygous beta thalassemia: a clinical trial.
Topics: Adult; Anemia, Sickle Cell; beta-Thalassemia; Blood Transfusion; Erythropoietin; Female; Fetal Hemog | 1995 |
Oral sodium phenylbutyrate therapy in homozygous beta thalassemia: a clinical trial.
Topics: Adult; Anemia, Sickle Cell; beta-Thalassemia; Blood Transfusion; Erythropoietin; Female; Fetal Hemog | 1995 |
Oral sodium phenylbutyrate therapy in homozygous beta thalassemia: a clinical trial.
Topics: Adult; Anemia, Sickle Cell; beta-Thalassemia; Blood Transfusion; Erythropoietin; Female; Fetal Hemog | 1995 |
Oral sodium phenylbutyrate therapy in homozygous beta thalassemia: a clinical trial.
Topics: Adult; Anemia, Sickle Cell; beta-Thalassemia; Blood Transfusion; Erythropoietin; Female; Fetal Hemog | 1995 |
1 other study available for 4-phenylbutyric acid and Anemia, Cooley's
| Article | Year |
|---|---|
Enhanced fetal hemoglobin production by phenylacetate and 4-phenylbutyrate in erythroid precursors derived from normal donors and patients with sickle cell anemia and beta-thalassemia.
Topics: Anemia, Sickle Cell; Azacitidine; beta-Thalassemia; Blotting, Northern; Butyrates; Butyric Acid; Cel | 1993 |