4-phenylbutyric acid has been researched along with Seizures in 4 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Here we examine the effects of valproic acid (VA) plus 4-phenylbutyric acid (4-PBA) on abnormal electrical brain activity, ER stress and apoptosis in acute seizures induced by pentylenetetrazole (PTZ)." | 8.12 | 4-Phenylbutyric Acid Plus Valproic Acid Exhibits the Therapeutic and Neuroprotective Effects in Acute Seizures Induced by Pentylenetetrazole. ( Amanvermez, R; Arslan, G; Gün, S; Rzayev, E; Tiryaki, ES, 2022) |
| " Here we examine the effects of valproic acid (VA) plus 4-phenylbutyric acid (4-PBA) on abnormal electrical brain activity, ER stress and apoptosis in acute seizures induced by pentylenetetrazole (PTZ)." | 4.12 | 4-Phenylbutyric Acid Plus Valproic Acid Exhibits the Therapeutic and Neuroprotective Effects in Acute Seizures Induced by Pentylenetetrazole. ( Amanvermez, R; Arslan, G; Gün, S; Rzayev, E; Tiryaki, ES, 2022) |
| " Anticonvulsant activity was tested against clonic seizures induced by pentylenetetrazole (PTZ, 60 mg/kg, i." | 3.85 | In silico Screening and Evaluation of the Anticonvulsant Activity of Docosahexaenoic Acid-Like Molecules in Experimental Models of Seizures. ( Gharibi Loron, A; Narenjkar, J; Sardari, S; Sayyah, M, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (25.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rzayev, E | 1 |
| Amanvermez, R | 1 |
| Gün, S | 1 |
| Tiryaki, ES | 1 |
| Arslan, G | 1 |
| Yokoi, N | 1 |
| Fukata, Y | 1 |
| Kase, D | 1 |
| Miyazaki, T | 1 |
| Jaegle, M | 1 |
| Ohkawa, T | 1 |
| Takahashi, N | 1 |
| Iwanari, H | 1 |
| Mochizuki, Y | 1 |
| Hamakubo, T | 1 |
| Imoto, K | 1 |
| Meijer, D | 1 |
| Watanabe, M | 1 |
| Fukata, M | 1 |
| Gharibi Loron, A | 1 |
| Sardari, S | 1 |
| Narenjkar, J | 1 |
| Sayyah, M | 1 |
| BILLMAN, JH | 1 |
| SMITH, WT | 1 |
| RENDALL, JL | 1 |
4 other studies available for 4-phenylbutyric acid and Seizures
| Article | Year |
|---|---|
4-Phenylbutyric Acid Plus Valproic Acid Exhibits the Therapeutic and Neuroprotective Effects in Acute Seizures Induced by Pentylenetetrazole.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Male; Neuroprotective Agents; Pentylenet | 2022 |
Chemical corrector treatment ameliorates increased seizure susceptibility in a mouse model of familial epilepsy.
Topics: ADAM Proteins; Animals; Disease Models, Animal; Epilepsy, Frontal Lobe; Genetic Predisposition to Di | 2015 |
In silico Screening and Evaluation of the Anticonvulsant Activity of Docosahexaenoic Acid-Like Molecules in Experimental Models of Seizures.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Docosahexaenoic Acids; Drug Design; Electroshock; | 2017 |
Anticonvulsants; esters of gamma-diethylamino-alpha-phenylbutyric acid.
Topics: Acids; Anticonvulsants; Esters; Humans; Phenylbutyrates; Seizures | 1947 |