4-phenylbutyric acid has been researched along with Right Ventricular Dysfunction in 2 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
| Excerpt | Relevance | Reference |
|---|---|---|
| "ERS is involved in ARDS-related right ventricular dysfunction." | 1.51 | [Protective effect of sodium 4-phenylbutyrate on rats with acute respiratory distress syndrome related right ventricular dysfunction by alleviating endoplasmic reticulum stress]. ( Ma, S; Wang, Y; Xu, C; Yao, J; Zhou, Y; Zuo, X, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ma, S | 1 |
| Zuo, X | 1 |
| Wang, Y | 1 |
| Yao, J | 1 |
| Zhou, Y | 1 |
| Xu, C | 1 |
| Wang, JJ | 1 |
| Zuo, XR | 1 |
| Xu, J | 1 |
| Zhou, JY | 1 |
| Kong, H | 1 |
| Zeng, XN | 1 |
| Xie, WP | 1 |
| Cao, Q | 1 |
2 other studies available for 4-phenylbutyric acid and Right Ventricular Dysfunction
| Article | Year |
|---|---|
[Protective effect of sodium 4-phenylbutyrate on rats with acute respiratory distress syndrome related right ventricular dysfunction by alleviating endoplasmic reticulum stress].
Topics: Animals; Antineoplastic Agents; Endoplasmic Reticulum Stress; Male; Phenylbutyrates; Rats; Rats, Spr | 2019 |
Evaluation and Treatment of Endoplasmic Reticulum (ER) Stress in Right Ventricular Dysfunction during Monocrotaline-Induced Rat Pulmonary Arterial Hypertension.
Topics: Activating Transcription Factor 6; Animals; Apoptosis; eIF-2 Kinase; Endoplasmic Reticulum Stress; H | 2016 |