4-phenylbutyric acid has been researched along with Retinitis Pigmentosa in 2 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
Retinitis Pigmentosa: Hereditary, progressive degeneration of the retina due to death of ROD PHOTORECEPTORS initially and subsequent death of CONE PHOTORECEPTORS. It is characterized by deposition of pigment in the retina.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Qiu, Y | 1 |
| Yao, J | 1 |
| Jia, L | 1 |
| Thompson, DA | 1 |
| Zacks, DN | 1 |
| Bonapace, G | 1 |
| Waheed, A | 1 |
| Shah, GN | 1 |
| Sly, WS | 1 |
2 other studies available for 4-phenylbutyric acid and Retinitis Pigmentosa
| Article | Year |
|---|---|
Shifting the balance of autophagy and proteasome activation reduces proteotoxic cell death: a novel therapeutic approach for restoring photoreceptor homeostasis.
Topics: Animals; Autophagy; Cell Death; Disease Models, Animal; Endoplasmic Reticulum; Endoplasmic Reticulum | 2019 |
Chemical chaperones protect from effects of apoptosis-inducing mutation in carbonic anhydrase IV identified in retinitis pigmentosa 17.
Topics: Acetazolamide; Animals; Apoptosis; Carbonic Anhydrase Inhibitors; Carbonic Anhydrase IV; COS Cells; | 2004 |