4-phenylbutyric acid has been researched along with Retinal Diseases in 4 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
Retinal Diseases: Diseases involving the RETINA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Retinal ischemia is a common cause of visual impairment for humans and animals." | 1.34 | Retinal ischemic injury rescued by sodium 4-phenylbutyrate in a rat model. ( Chang, PH; Huang, YP; Jeng, YY; Lin, CT; Lin, NT; Liu, CH; Pang, VF, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, J | 1 |
| Taylor, RL | 1 |
| Baines, RA | 2 |
| Swanton, L | 1 |
| Freeman, S | 1 |
| Corneo, B | 1 |
| Patel, A | 1 |
| Marmorstein, A | 1 |
| Knudsen, T | 1 |
| Black, GC | 1 |
| Manson, F | 1 |
| Milenkovic, A | 1 |
| Milenkovic, VM | 1 |
| Wetzel, CH | 1 |
| Weber, BHF | 1 |
| Uggenti, C | 1 |
| Briant, K | 1 |
| Streit, AK | 1 |
| Thomson, S | 1 |
| Koay, YH | 1 |
| Swanton, E | 1 |
| Manson, FD | 1 |
| Jeng, YY | 1 |
| Lin, NT | 1 |
| Chang, PH | 1 |
| Huang, YP | 1 |
| Pang, VF | 1 |
| Liu, CH | 1 |
| Lin, CT | 1 |
4 other studies available for 4-phenylbutyric acid and Retinal Diseases
| Article | Year |
|---|---|
Small Molecules Restore Bestrophin 1 Expression and Function of Both Dominant and Recessive Bestrophinopathies in Patient-Derived Retinal Pigment Epithelium.
Topics: Antineoplastic Agents; Bestrophins; Blotting, Western; Cell Membrane; Chloride Channels; Cycloheximi | 2020 |
BEST1 protein stability and degradation pathways differ between autosomal dominant Best disease and autosomal recessive bestrophinopathy accounting for the distinct retinal phenotypes.
Topics: Algorithms; Animals; Bestrophins; Cell Line; Dogs; Endoplasmic Reticulum; Eye Diseases, Hereditary; | 2018 |
Restoration of mutant bestrophin-1 expression, localisation and function in a polarised epithelial cell model.
Topics: Animals; Bestrophins; Biotinylation; Cell Polarity; Dogs; Endoplasmic Reticulum; Epithelial Cells; E | 2016 |
Retinal ischemic injury rescued by sodium 4-phenylbutyrate in a rat model.
Topics: Animals; Cell Count; Cell Death; Dose-Response Relationship, Drug; Glaucoma; Ischemia; Male; Microsc | 2007 |