4-phenylbutyric acid has been researched along with Retinal Degeneration in 2 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
Retinal Degeneration: A retrogressive pathological change in the retina, focal or generalized, caused by genetic defects, inflammation, trauma, vascular disease, or aging. Degeneration affecting predominantly the macula lutea of the retina is MACULAR DEGENERATION. (Newell, Ophthalmology: Principles and Concepts, 7th ed, p304)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Qiu, Y | 1 |
| Yao, J | 1 |
| Jia, L | 1 |
| Thompson, DA | 1 |
| Zacks, DN | 1 |
| Jin, M | 1 |
| Li, S | 1 |
| Hu, J | 1 |
| Jin, HH | 1 |
| Jacobson, SG | 1 |
| Bok, D | 1 |
2 other studies available for 4-phenylbutyric acid and Retinal Degeneration
| Article | Year |
|---|---|
Shifting the balance of autophagy and proteasome activation reduces proteotoxic cell death: a novel therapeutic approach for restoring photoreceptor homeostasis.
Topics: Animals; Autophagy; Cell Death; Disease Models, Animal; Endoplasmic Reticulum; Endoplasmic Reticulum | 2019 |
Functional Rescue of Retinal Degeneration-Associated Mutant RPE65 Proteins.
Topics: Blotting, Western; Catalytic Domain; Cell Line; Cells, Cultured; cis-trans-Isomerases; Cold Temperat | 2016 |