4-phenylbutyric acid has been researched along with Reperfusion Injury in 11 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
Reperfusion Injury: Adverse functional, metabolic, or structural changes in tissues that result from the restoration of blood flow to the tissue (REPERFUSION) following ISCHEMIA.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In vivo, the induction of ER stress by ischemia-reperfusion and the impact of ER stress amelioration by a small molecule chaperon 4-phenylbutyric acid on liver immune response were studied in a murine partial liver warm ischemia model." | 3.78 | Endoplasmic reticulum stress modulates liver inflammatory immune response in the pathogenesis of liver ischemia and reperfusion injury. ( Bai, L; Busuttil, RW; Cheng, Q; Gao, F; Kupiec-Weglinski, JW; Liu, J; Ren, F; Shen, X; Zhai, Y, 2012) |
| "We investigated the effects of 4-PBA on neuropathic pain associated with VPN induced by ischaemia-reperfusion (IR) and its underlying mechanisms." | 1.51 | 4-Phenylbutyric acid protects against vasculitic peripheral neuropathy induced by ischaemia-reperfusion through attenuating endoplasmic reticulum stress. ( Chen, CH; Chuang, CW; Kao, MC; Lin, HY; Pan, PT; Shih, PC; Wang, PK, 2019) |
| "Retinal ischemia is a common cause of visual impairment for humans and animals." | 1.34 | Retinal ischemic injury rescued by sodium 4-phenylbutyrate in a rat model. ( Chang, PH; Huang, YP; Jeng, YY; Lin, CT; Lin, NT; Liu, CH; Pang, VF, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (18.18) | 29.6817 |
| 2010's | 9 (81.82) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gu, Y | 1 |
| Huang, F | 1 |
| Wang, Y | 1 |
| Chen, C | 1 |
| Wu, S | 1 |
| Zhou, S | 1 |
| Hei, Z | 1 |
| Yuan, D | 1 |
| Chen, CH | 1 |
| Shih, PC | 1 |
| Lin, HY | 1 |
| Wang, PK | 1 |
| Pan, PT | 1 |
| Chuang, CW | 1 |
| Kao, MC | 1 |
| Nan, D | 1 |
| Jin, H | 1 |
| Deng, J | 1 |
| Yu, W | 1 |
| Liu, R | 1 |
| Sun, W | 1 |
| Huang, Y | 1 |
| Lu, H | 1 |
| Lu, L | 2 |
| Xu, ZC | 1 |
| Lu, YJ | 1 |
| Zhao, B | 1 |
| Zhuang, L | 1 |
| Hao, BB | 1 |
| Zhang, F | 1 |
| Tung, WF | 1 |
| Chen, WJ | 1 |
| Hung, HC | 1 |
| Liu, GY | 1 |
| Tung, JN | 1 |
| Huang, CC | 1 |
| Lin, CL | 1 |
| Yue, ZS | 1 |
| Zeng, LR | 1 |
| Quan, RF | 1 |
| Tang, YH | 1 |
| Zheng, WJ | 1 |
| Qu, G | 1 |
| Xu, CD | 1 |
| Zhu, FB | 1 |
| Huang, ZM | 1 |
| Zhou, H | 1 |
| Zhu, J | 1 |
| Yue, S | 1 |
| Busuttil, RW | 2 |
| Kupiec-Weglinski, JW | 2 |
| Wang, X | 1 |
| Zhai, Y | 2 |
| Ben Mosbah, I | 1 |
| Alfany-Fernández, I | 1 |
| Martel, C | 1 |
| Zaouali, MA | 1 |
| Bintanel-Morcillo, M | 1 |
| Rimola, A | 1 |
| Rodés, J | 1 |
| Brenner, C | 1 |
| Roselló-Catafau, J | 1 |
| Peralta, C | 1 |
| Liu, J | 1 |
| Ren, F | 1 |
| Cheng, Q | 1 |
| Bai, L | 1 |
| Shen, X | 1 |
| Gao, F | 1 |
| Vilatoba, M | 1 |
| Eckstein, C | 1 |
| Bilbao, G | 1 |
| Smyth, CA | 1 |
| Jenkins, S | 1 |
| Thompson, JA | 1 |
| Eckhoff, DE | 1 |
| Contreras, JL | 1 |
| Jeng, YY | 1 |
| Lin, NT | 1 |
| Chang, PH | 1 |
| Huang, YP | 1 |
| Pang, VF | 1 |
| Liu, CH | 1 |
| Lin, CT | 1 |
11 other studies available for 4-phenylbutyric acid and Reperfusion Injury
| Article | Year |
|---|---|
Connexin32 plays a crucial role in ROS-mediated endoplasmic reticulum stress apoptosis signaling pathway in ischemia reperfusion-induced acute kidney injury.
Topics: Acetylcysteine; Acute Kidney Injury; Animals; Apoptosis; Connexins; Endoplasmic Reticulum Chaperone | 2018 |
4-Phenylbutyric acid protects against vasculitic peripheral neuropathy induced by ischaemia-reperfusion through attenuating endoplasmic reticulum stress.
Topics: Animals; Biomarkers; Endoplasmic Reticulum Stress; Inflammation; Male; Neuralgia; NF-kappa B; Periph | 2019 |
Cilostazol ameliorates ischemia/reperfusion-induced tight junction disruption in brain endothelial cells by inhibiting endoplasmic reticulum stress.
Topics: Animals; Blood-Brain Barrier; Cells, Cultured; Cilostazol; Cyclic AMP; Drug Evaluation, Preclinical; | 2019 |
Tauroursodeoxycholic acid and 4-phenyl butyric acid alleviate endoplasmic reticulum stress and improve prognosis of donation after cardiac death liver transplantation in rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Cholagogues and Choleretics; Death; Dela | 2014 |
4-Phenylbutyric Acid (4-PBA) and Lithium Cooperatively Attenuate Cell Death during Oxygen-Glucose Deprivation (OGD) and Reoxygenation.
Topics: Brain Ischemia; Cell Death; Cells, Cultured; Drug Synergism; Endoplasmic Reticulum Stress; Glucose; | 2015 |
4‑Phenylbutyrate protects rat skin flaps against ischemia‑reperfusion injury and apoptosis by inhibiting endoplasmic reticulum stress.
Topics: Animals; Apoptosis; Endoplasmic Reticulum; Endoplasmic Reticulum Stress; Gene Expression Regulation; | 2016 |
The Dichotomy of Endoplasmic Reticulum Stress Response in Liver Ischemia-Reperfusion Injury.
Topics: Activating Transcription Factors; Adenine; AMP-Activated Protein Kinases; Animals; Autophagy; Autoph | 2016 |
Endoplasmic reticulum stress inhibition protects steatotic and non-steatotic livers in partial hepatectomy under ischemia-reperfusion.
Topics: Activating Transcription Factor 6; Animals; Caspase 12; Cytochromes c; Endoplasmic Reticulum; Fatty | 2010 |
Endoplasmic reticulum stress modulates liver inflammatory immune response in the pathogenesis of liver ischemia and reperfusion injury.
Topics: Animals; Endoplasmic Reticulum; Gene Expression Regulation; Hepatocytes; Immune System; Inflammation | 2012 |
Sodium 4-phenylbutyrate protects against liver ischemia reperfusion injury by inhibition of endoplasmic reticulum-stress mediated apoptosis.
Topics: Animals; Antineoplastic Agents; Apoptosis; Caspase 12; Caspases; CCAAT-Enhancer-Binding Proteins; En | 2005 |
Retinal ischemic injury rescued by sodium 4-phenylbutyrate in a rat model.
Topics: Animals; Cell Count; Cell Death; Dose-Response Relationship, Drug; Glaucoma; Ischemia; Male; Microsc | 2007 |